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Human Monoclonal GZMA Primary Antibody for FACS, IP - ABIN2689529
Barry, Heibein, Pinkoski, Lee, Moyer, Green, Bleackley: Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid. in Molecular and cellular biology 2000
Show all 6 Pubmed References
Human Monoclonal GZMA Primary Antibody for IHC (p), WB - ABIN2473883
Mayne, Allen, Bowell: 'Partial D' women with anti-D alloimmunization in pregnancy. in Clinical and laboratory haematology 1992
Show all 4 Pubmed References
Human Polyclonal GZMA Primary Antibody for ELISA - ABIN4274922
Martinvalet, Dykxhoorn, Ferrini, Lieberman: Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. in Cell 2008
Human Polyclonal GZMA Primary Antibody for WB - ABIN4316050
Bem, Bos, Bots, Wolbink, van Ham, Medema, Lutter, van Woensel: Activation of the granzyme pathway in children with severe respiratory syncytial virus infection. in Pediatric research 2008
Human Monoclonal GZMA Primary Antibody for FACS - ABIN4896974
Kreft, Verbraak, Wierenga-Wolf, van Meurs, Oostra, Laman, Hintzen: The IL-7Rα pathway is quantitatively and functionally altered in CD8 T cells in multiple sclerosis. in Journal of immunology (Baltimore, Md. : 1950) 2012
Human Monoclonal GZMA Primary Antibody for FACS - ABIN4896973
Kurioka, Ussher, Cosgrove, Clough, Fergusson, Smith, Kang, Walker, Hansen, Willberg, Klenerman: MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets. in Mucosal immunology 2015
GzmA and gzmB were predominantly expressed by natural killer cells, and during abdominal sepsis, the percentage of these cells expressing gzms in peritoneal lavage fluid decreased, while the amount of expression in the gzm(+) cells increased
a novel endogenous trigger for autoimmune diabetes and an in vivo role for granzyme A in maintaining immune tolerance.
this study shows that gzmA and gzmB partly regulate local inflammation during early pneumonia but eventually play an insignificant role during pneumosepsis by the common human pathogen Klebsiella pneumoniae
Granzyme A does not have a crucial role in vivo in the protective response to tuberculosis.
The results, in susceptible B6 mice for GzmB and in resistant 129/Sv mice for GzmA and/or the GzmB cluster, point to granzyme-mediated host defense regulation in the liver in experimental visceral leishmaniasis.
Estrogen increases the extracellular expression and interleukin (IL)-12 (show IL12A Antibodies)-induced activity of a critical member of serine protease (show F2 Antibodies) family granzyme A.
functional divergence between human and mouse granzyme A
Regulated secretion of granzyme A and cytotoxic killing was enhanced and correlated with increased vesicle-associated membrane protein 7 (show VAMP7 Antibodies) availability.
GzmA deficiency in filarial infection is linked with reduced inflammation and a trend toward increased alternatively activated macrophages.
granzyme A- and B-cluster deficiency delays the acute progression of pneumovirus disease by reducing alveolar injury.
granzyme A in human platelets increases with aging
GzmA plays an unfavorable role in host defense during pneumococcal pneumonia by a mechanism that does not depend on natural killer cells.
Carbamate pesticides significantly reduced the intracellular levels of perforin (show PRF1 Antibodies), GrA (show NR3C1 Antibodies), GrB, Gr3 (show PRLHR Antibodies)/K, and GRN (show GRN Antibodies) in NK-92CI cells.
Our results suggest that granzyme A could be considered another biomarker of TB, that can be used, other than IFN-gamma (show IFNG Antibodies), to discriminate between patients with active TB and LTBI subjects
Delivered into parasite infected cells by granulysin (show GNLY Antibodies) and perforin (show PRF1 Antibodies), granzymes generate superoxide and inactivate oxidative defense enzymes to kill the parasite.
Taken together, the authors verified that histone H3 (show HIST3H3 Antibodies) is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin.
Results reveal enhanced intra- and extracellular expression of gzmA and B in patients with pulmonary TB, suggesting that gzms are part of the host response to tuberculosis.
Levels of GZMA and ITGAE (show ITGAE Antibodies) mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients.
GzmA and GzmB expressing cells in the airways and lung parenchyma was higher in subjects who died from asthma
GZMA, GBP5 and CD64 (show FCGR1A Antibodies) genes show promise as a rapid diagnostic markers separating tuberculosis from other pulmonary diseases.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.
, Granzyme A
, BLT esterase
, H factor
, Hanukah factor
, autocrine thymic lymphoma granzyme-like serine protease
, serine esterase 1
, t cell-specific serine protease 1
, CTL tryptase
, Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease)
, cytotoxic T-lymphocyte proteinase 1
, h factor