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CNS Cell Markers

Neural stem cells acting as a source of various cell types are a subpopulation of cells that can self-renewal and proliferate identical cells. They are multipotent to generate diversity neural lineages, encompassing neurons, astrocytes, and oligodendrocytes. Central nervous system (CNS) cell markers are fundamental in elucidating the functions of different neural cell types and their involvement in various neurological diseases and disorders. Researchers and clinicians rely on these antibodies to gain insights into the cellular composition of the central nervous system and to develop therapies and diagnostic tools for conditions such as neurodegenerative diseases, brain injuries, and neuroinflammatory disorders. These antibodies are used in various experimental techniques, including immunohistochemistry and immunofluorescence, to visualize and study the distribution of specific cell types within the CNS. antibodies-online offers an outstanding selection of marker antibodies and kits for detection of neurons, microglia and astrocytes. We also offer proteins, peptides and reagents for neuroscience research.

Types of cell markers

The investigation of the basic processes in the CNS is of high relevance for research on neurodegenerative diseases. antibodies-online aims to support research with hand-picked, high-quality antibodies and kits against many important cell type markers.

Neural Progenitor Cells

Neural progenitor cells (NPCs)" are the progenitor cells of the CNS that give rise to many, if not all, of the glial and neuronal cell types that populate the CNS.(2) Please see the highlighted antibodies below.

Product
Reactivity
Clone
Application
Validations
Cat. No.
Quantity
Reactivity Human
Clone
Application WB, IF, FACS, IHC (p), ICC, IP, IHC (fro), CUT&RUN
Validations
  • (11)
  • (15)
  • (1)
Cat. No. ABIN2855074
Quantity 100 μL
Reactivity Human
Clone RB16253
Application WB, FACS, IF, IHC (p)
Validations
  • (1)
  • (7)
Cat. No. ABIN388764
Quantity 400 μL
Reactivity Human
Clone 1H12C4B5
Application WB, ELISA, IHC, FACS, ICC
Validations
  • (1)
  • (6)
Cat. No. ABIN969332
Quantity 100 μL
Reactivity Human
Clone 1F6G2
Application WB, ELISA, FACS, IHC, ICC
Validations
  • (6)
Cat. No. ABIN5542664
Quantity 0.1 mg
Reactivity Human
Clone
Application WB, IHC, IF
Validations
  • (6)
Cat. No. ABIN7270655
Quantity 100 μL
Reactivity Human, Mouse, Rat
Clone
Application WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validations
  • (4)
  • (4)
Cat. No. ABIN737616
Quantity 100 μL
Reactivity Human
Clone 8E1
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7127821
Quantity 100 μL

Microglia

Although microglia were first described as ramified brain-resident phagocytes, research conducted over the past century has expanded considerably upon this narrow view and ascribed many functions to these dynamic CNS inhabitants. Microglia are now considered among the most versatile cells in the body, possessing the capacity to morphologically and functionally adapt to their ever-changing surroundings.(3) Please see the highlighted antibodies below.

Product
Reactivity
Clone
Application
Validations
Cat. No.
Quantity
Reactivity Chicken, Human, Mouse, Rat
Clone
Application WB, ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro)
Validations
  • (10)
  • (5)
Cat. No. ABIN677228
Quantity 100 μL
Reactivity Human, Mouse, Rat
Clone
Application FACS
Validations
  • (4)
  • (7)
Cat. No. ABIN741285
Quantity 100 μL
Reactivity Human
Clone 3F7D3
Application FACS, WB, IHC, ELISA, ICC
Validations
  • (1)
  • (8)
Cat. No. ABIN2682982
Quantity 0.1 mg
Reactivity Human
Clone
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7438127
Quantity 100 μL
Reactivity Human
Clone
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7442747
Quantity 100 μL
Reactivity Human, Non-Human Primate
Clone MEM-55
Application FACS, WB, IHC (p), IP
Validations
  • (1)
  • (5)
Cat. No. ABIN94140
Quantity 0.1 mg
Reactivity Human
Clone UCHL1
Application FACS, IHC, IP
Validations
  • (1)
Cat. No. ABIN5563934
Quantity 100 μg
Reactivity Human, Mouse, Rat
Clone
Application WB, IHC, ELISA
Validations
Cat. No. ABIN7120195
Quantity 100 μg

Astrocytes

Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS.(4) Please see the highlighted antibodies below.

Product
Reactivity
Clone
Application
Validations
Cat. No.
Quantity
Reactivity Human, Mouse, Rat
Clone
Application WB, ELISA, IHC (p), ICC, FACS, IHC (fro), IF (cc), IF (p)
Validations
  • (20)
  • (8)
Cat. No. ABIN726200
Quantity 100 μL
Reactivity Human, Mouse, Rat
Clone
Application WB, ICC, IHC (p), FACS, IF (cc), IF (p), IHC (fro)
Validations
  • (4)
  • (6)
Cat. No. ABIN671181
Quantity 100 μL
Reactivity Human, Mouse, Rat
Clone RB22934
Application WB, FACS, IHC (p)
Validations
  • (7)
Cat. No. ABIN651265
Quantity 400 μL
Reactivity Dog, Human
Clone 3D2
Application WB, IHC, IF, IHC (p)
Validations
  • (8)
Cat. No. ABIN1496585
Quantity 100 μL
Reactivity Human, Mouse, Rat
Clone
Application WB, IHC, ICC
Validations
  • (3)
  • (1)
Cat. No. ABIN2690503
Quantity 50 μg

Clone
Application WB, IHC
Validations
  • (1)
  • (7)
Cat. No. ABIN2778148
Quantity 100 μL
Reactivity Human
Clone
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7435589
Quantity 100 μL
Reactivity Human
Clone
Application WB, IHC, IF/ICC
Validations
  • (2)
Cat. No. ABIN3001589
Quantity 400 μL
Reactivity Human
Clone D10
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7425635
Quantity 100 μL

Immature Neurons

Immature neurons, also known as neural precursor cells or neuroblasts, represent an early stage in the development of the nervous system. These cells have not yet fully differentiated into mature, functional neurons and retain the capacity for further development. Immature neurons are often found in specific regions of the brain, such as the subventricular zone and the dentate gyrus of the hippocampus, where they can contribute to neurogenesis and brain plasticity.

Product
Reactivity
Clone
Application
Validations
Cat. No.
Quantity
Reactivity Dog, Human, Mouse, Pig, Rat
Clone TU-20
Application WB, FACS, IHC (p), ICC
Validations
  • (15)
  • (9)
Cat. No. ABIN93911
Quantity 0.1 mg
Reactivity Human
Clone 2G5
Application WB, ELISA, IHC, ICC, FACS
Validations
  • (1)
  • (7)
Cat. No. ABIN969513
Quantity 0.1 mg
Reactivity Human
Clone
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7435226
Quantity 100 μL
Reactivity Human, Monkey, Mouse
Clone 5B1G11
Application FACS, WB, IHC, ELISA
Validations
  • (7)
Cat. No. ABIN7193604
Quantity 0.1 mg
Reactivity Human
Clone 4G12B4
Application WB, ELISA, IHC, FACS
Validations
  • (7)
Cat. No. ABIN7193474
Quantity 0.1 mg

Clone
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN6747024
Quantity 100 μL
Reactivity Human
Clone
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7150959
Quantity 100 μg

Oligodendrocytes

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons.(5) Please see the highlighted antibodies below.

Product
Reactivity
Clone
Application
Validations
Cat. No.
Quantity
Reactivity Human
Clone
Application WB, IHC, IP, ICC
Validations
  • (8)
Cat. No. ABIN7429418
Quantity 100 μL
Reactivity Human, Mouse, Rat
Clone
Application WB, ELISA, FACS, IHC (p), IF (cc), ICC, IF (p), IHC (fro)
Validations
  • (1)
  • (5)
Cat. No. ABIN730738
Quantity 100 μL
Reactivity Human
Clone
Application WB, ELISA, IF, FACS
Validations
  • (11)
Cat. No. ABIN185357
Quantity 100 μg
Reactivity Dog, Guinea Pig, Horse, Human, Mouse, Rat
Clone
Application WB, IHC
Validations
  • (1)
  • (6)
Cat. No. ABIN2777566
Quantity 100 μL
Reactivity Human, Mouse
Clone RB21242
Application WB, IHC (p), FACS
Validations
  • (4)
Cat. No. ABIN390900
Quantity 400 μL
Reactivity Human, Mouse
Clone
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7256110
Quantity 200 μL
Reactivity Dog, Human
Clone 3D9
Application WB, IF, FACS
Validations
  • (4)
Cat. No. ABIN1498007
Quantity 100 μL
Reactivity Human, Mouse
Clone
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7001420
Quantity 20 μL
Reactivity Human, Mouse, Rat
Clone
Application WB, IHC
Validations
  • (1)
  • (1)
Cat. No. ABIN1742247
Quantity 50 μg
Reactivity Human, Mouse
Clone
Application WB, ELISA, IHC
Validations
Cat. No. ABIN602071
Quantity 100 μg

Mature Neurons

Mature neurons promote survival at all costs by employing multiple, often redundant, strategies to prevent cell death by apoptosis. This dramatic shift from permitting cell death to ensuring cellular survival is critical, as these post-mitotic cells must provide neuronal circuitry for an organism's entire lifetime.(6) Please see the highlighted antibodies below.

Product
Reactivity
Clone
Application
Validations
Cat. No.
Quantity
Reactivity Human, Mouse
Clone 1H3B2
Application WB, IHC, ELISA, ICC, FACS
Validations
  • (6)
  • (1)
Cat. No. ABIN5542704
Quantity 0.1 mg
Reactivity Human, Mouse
Clone RB32966
Application WB, IF, IHC (p), FACS
Validations
  • (5)
  • (6)
Cat. No. ABIN1881862
Quantity 400 μL
Reactivity Human
Clone
Application WB, IHC, IF
Validations
  • (2)
  • (8)
Cat. No. ABIN3016265
Quantity 100 μL
Reactivity Human
Clone
Application WB, IHC, IP, ICC
Validations
  • (7)
Cat. No. ABIN7432400
Quantity 100 μL
Reactivity Human, Mouse, Rat
Clone
Application WB, ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p)
Validations
  • (1)
  • (5)
Cat. No. ABIN725555
Quantity 100 μL
Reactivity Human
Clone
Application WB, IHC, ICC, IP
Validations
  • (5)
Cat. No. ABIN7434476
Quantity 100 μL
Reactivity Human, Rat
Clone
Application WB, ELISA, IHC
Validations
  • (1)
  • (4)
Cat. No. ABIN185022
Quantity 100 μg
Reactivity Human, Mouse, Rat
Clone
Application WB, IHC, ELISA, IF, IP, IHC (p)
Validations
  • (4)
Cat. No. ABIN396947
Quantity 50 μg
Reactivity Human, Mouse
Clone
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN3184724
Quantity 100 μL
Reactivity Human, Mouse, Rat
Clone
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7243316
Quantity 200 μL
Reactivity Human
Clone 5A9
Application IHC, ELISA
Validations
  • (2)
Cat. No. ABIN108425
Quantity 100 μg

References

  1. Zhang, Jiao: "Molecular Biomarkers for Embryonic and Adult Neural Stem Cell and Neurogenesis." in: BioMed research international, Vol. 2015, pp. 727542, (2016) (PubMed).
  2. Martínez-Cerdeño, Noctor: "Neural Progenitor Cell Terminology." in: Frontiers in neuroanatomy, Vol. 12, pp. 104, (2018) (PubMed).
  3. Nayak, Roth, McGavern: "Microglia development and function." in: Annual review of immunology, Vol. 32, pp. 367-402, (2014) (PubMed).
  4. Sofroniew, Vinters: "Astrocytes: biology and pathology." in: Acta neuropathologica, Vol. 119, Issue 1, pp. 7-35, (2010) (PubMed).
  5. Bradl, Lassmann: "Oligodendrocytes: biology and pathology." in: Acta neuropathologica, Vol. 119, Issue 1, pp. 37-53, (2010) (PubMed).
  6. Kole, Annis, Deshmukh: "Mature neurons: equipped for survival." in: Cell death & disease, Vol. 4, pp. e689, (2014) (PubMed).
Rene von der Forst
Rene von der Forst, MSE
Marketing and E-Commerce Manager

Master of Science in engineering. 12+ years of experience in marketing and e-commerce in the life science sector.

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