CNS Cell markers

Neural stem cells (NSCs) acting as a source of various cell types are a subpopulation of cells that can self-renewal and proliferate identical cells. They are multipotent to generate diversity neural lineages, encompassing neurons, astrocytes, and oligodendrocytes.(1) antibodies-online offers an outstanding selection of antibodies and kits against many cell type markers for detection of neurons, microglia and astrocytes. We also offer proteins, peptides and reagents for neuroscience research.

Types of cell markers

The investigation of the basic processes in the CNS is of high relevance for research on neurodegenerative diseases. antibodies-online aims to support research with hand-picked, high-quality antibodies and kits against many important cell type markers.

Neural Progenitor Cells

Neural progenitor cells (NPCs)" are the progenitor cells of the CNS that give rise to many, if not all, of the glial and neuronal cell types that populate the CNS.(2) Please see the highlighted antibodies below.

Product Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-SOX1 antibody (SRY (Sex Determining Region Y)-Box 1) (N-Term) Cow, Human, Monkey, Mouse Polyclonal WB ABIN6746080 100 μL element-ABIN6746080
anti-Paired Box 3 (PAX3) (AA 142-203) antibody Human, Mouse Monoclonal ELISA, WB ABIN1724817 0.1 mg element-ABIN1724817

Microglia

Although microglia were first described as ramified brain-resident phagocytes, research conducted over the past century has expanded considerably upon this narrow view and ascribed many functions to these dynamic CNS inhabitants. Microglia are now considered among the most versatile cells in the body, possessing the capacity to morphologically and functionally adapt to their ever-changing surroundings.(3) Please see the highlighted antibodies below.

Product Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-CD11b antibody (Integrin alpha M) (AA 623-728) Human Monoclonal ICC, ELISA, WB ABIN1724905 0.1 mg element-ABIN1724905
anti-NOS2 antibody (Nitric Oxide Synthase 2, Inducible) Human, Mouse Monoclonal FACS, IHC, ELISA, WB ABIN969551 0.1 mg element-ABIN969551

Astrocytes

Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS.(4) Please see the highlighted antibodies below.

Product Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-ALDH1L1 antibody (Aldehyde Dehydrogenase 1 Family, Member L1) (C-Term) Human, Mouse, Rat Polyclonal IHC ABIN965537 0.1 mg element-ABIN965537
anti-GFAP antibody (Glial Fibrillary Acidic Protein) Human Monoclonal ICC, IHC, ELISA, WB ABIN969173 100 μL element-ABIN969173
anti-IGFBP3 antibody (Insulin-Like Growth Factor Binding Protein 3) (AA 214-252) Human, Rat Polyclonal IHC (p), ELISA, WB ABIN3043859 100 μg element-ABIN3043859
anti-Aquaporin 4 antibody (AQP4) (AA 295-323) Human, Mouse, Rat Polyclonal IHC (fro), IHC (p), WB ABIN3043789 100 μg element-ABIN3043789

Immature Neurons

Product Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-Doublecortin antibody (DCX) (AA 362-411) Human Monoclonal ICC, FACS, IHC, ELISA, WB ABIN969513 0.1 mg element-ABIN969513
anti-NEUROD1 antibody (Neuronal Differentiation 1) (AA 26-91) Human, Mouse Monoclonal ELISA, WB ABIN1724758 0.1 mg element-ABIN1724758
anti-Stathmin 1 antibody (STMN1) (C-Term) Human, Mouse Polyclonal ELISA, EIA, IHC, WB ABIN185573 100 μg element-ABIN185573
anti-TUBB3 antibody (Tubulin, beta 3) (AA 443-450) Human, Mouse, Rat Polyclonal ICC, IP, IHC, WB ABIN1742553 200 μL element-ABIN1742553

Oligodendrocytes

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons.(5) Please see the highlighted antibodies below.

Product Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-OLIG1 antibody (Oligodendrocyte Transcription Factor 1) Mammalian Monoclonal ISt, IHC ABIN1304878 5 mL element-ABIN1304878
anti-Myelin Oligodendrocyte Glycoprotein (MOG) (AA 50-100) antibody Human, Mouse, Rat Polyclonal WB ABIN1574230 40 μg element-ABIN1574230
anti-OLIG2 antibody (Oligodendrocyte Lineage Transcription Factor 2) Human Monoclonal ICC, IHC, ELISA, WB ABIN969331 100 μL element-ABIN969331
anti-Myelin Basic Protein (MBP) antibody Human Monoclonal ICC, FACS, IHC, ELISA, WB ABIN969279 100 μL element-ABIN969279

Mature Neurons

Mature neurons promote survival at all costs by employing multiple, often redundant, strategies to prevent cell death by apoptosis. This dramatic shift from permitting cell death to ensuring cellular survival is critical, as these post-mitotic cells must provide neuronal circuitry for an organism's entire lifetime.(6) Please see the highlighted antibodies below.

Product Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-tau antibody (tau Protein) (AA 3-214) Human, Mouse, Rat Monoclonal ICC, IP, IHC, WB ABIN1742567 100 μg element-ABIN1742567
anti-Synaptophysin antibody (SYP) Human, Rat Monoclonal IHC, ELISA, WB ABIN969428 100 μL element-ABIN969428
anti-GRIN1/NMDAR1 antibody (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1) (AA 1-564) Rat Monoclonal IP, WB ABIN361405 15 μg element-ABIN361405
anti-NeuN antibody (RNA Binding Protein, Fox-1 Homolog (C. Elegans) 3) (AA 70-120) Human, Mouse, Rat Polyclonal IF (p), IHC (p), WB ABIN732068 100 μL element-ABIN732068

References

(1) Zhang J, Jiao J. Molecular Biomarkers for Embryonic and Adult Neural Stem Cell and Neurogenesis. Biomed Res Int. 2015;2015:727542. doi: 10.1155/2015/727542. Epub 2015 Sep 1. PMID: 26421301; PMCID: PMC4569757.

(2) Martínez-Cerdeño V, Noctor SC. Neural Progenitor Cell Terminology. Front Neuroanat. 2018 Dec 6;12:104. doi: 10.3389/fnana.2018.00104. PMID: 30574073; PMCID: PMC6291443.

(3) Nayak D, Roth TL, McGavern DB. Microglia development and function. Annu Rev Immunol. 2014;32:367-402. doi: 10.1146/annurev-immunol-032713-120240. Epub 2014 Jan 22. PMID: 24471431; PMCID: PMC5001846.

(4) Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol. 2010 Jan;119(1):7-35. doi: 10.1007/s00401-009-0619-8. Epub 2009 Dec 10. PMID: 20012068; PMCID: PMC2799634.

(5) Bradl M, Lassmann H. Oligodendrocytes: biology and pathology. Acta Neuropathol. 2010 Jan;119(1):37-53. doi: 10.1007/s00401-009-0601-5. Epub 2009 Oct 22. PMID: 19847447; PMCID: PMC2799635.

(6) Kole AJ, Annis RP, Deshmukh M. Mature neurons: equipped for survival. Cell Death Dis. 2013 Jun 27;4(6):e689. doi: 10.1038/cddis.2013.220. PMID: 23807218; PMCID: PMC3702294.