SARS-CoV-2 ELISA Kits

antibodies-online offers a handpicked selection of proven SARS-CoV-2 ELISA Kits for the detection of IgG and the COVID-19 IgM in human samples. First assays and test kits for COVID-19 utilized genetic material directly against SARS-COV-2. However, comparisons of the genetic sequences of SARS-CoV-2 have shown similarities to SARS-CoV and other coronaviruses revealing problems in their specificity.

Qualitative and quantitative human IgG and IgM ELISAs overcome the problem as they are produced by the human immune system during and after an infection. IgG is the most abundant immunoglobulin to be produced in response to an antigen and is maintained in the body after initial exposure for long term response. Antibody titer is 4 times or higher than that of the acute phase. IgM on the other hand is the first immunoglobulin to be produced in response to an antigen and is primarily detected during the early onset of disease.1 Clinicians and researchers use ELISA kits to estimate antibodies in samples of COVID-19 patients.

Western blot (WB) and microneutralisation (MN) assay of samples collected at convalescence of COVID-19 showed a prominent response against the nucleocapsid (N) and spike (S) protein, confirming their role as main candidate diagnostic targets for SARS-CoV-2 ELISA kits.2 Spike (S) protein ELISA kits focus on the infection itself. The interaction of N protein with the host cell, the modulation of cell signaling pathways in particular, has big impact on the course of COVID-19 disease in human patients.

The N protein triggers activation of the lectin pathway of the complement system through interaction with mannose binding lectin (MBL)-associated serine protease (MASP)2. Released soluble N protein dimers interact with MASP-2, further accelerating MASP-2 activation and activation of the complements system. The positive feedback through cell lysis and release of N-protein leads to elevation of pro-inflammatory cytokines, characterized as cytokine storm. 3,4

SARS-CoV-2 IgG / IgM ELISA Kits

Product Sample Type Analytical Method Cat. No. Relevance ProductGrid: uniqueid
SARS-CoV-2 IgG Antibody ELISA Kit Serum Qualitative Indirect ELISA ABIN6952525 element-ABIN6952525
SARS-CoV-2 IgM Antibody ELISA Kit Plasma, Serum Quantitative Indirect ELISA ABIN6952773 element-ABIN6952773
SARS-CoV-2 IgM Antibody ELISA Kit Serum Qualitative Sandwich ELISA ABIN6952526 element-ABIN6952526
SARS-CoV-2 N-Protein Antibody ELISA Kit Nasal Secretions, Plasma, Saliva, Serum Qualitative Sandwich ELISA ABIN6952781 element-ABIN6952781
SARS-CoV-2 N-Protein IgA Antibody ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952758 element-ABIN6952758
SARS-CoV-2 N-Protein IgG Antibody (SARS-CoV-2 N IgG) ELISA Kit Plasma, Serum Qualitative Indirect ELISA ABIN6952662 element-ABIN6952662
SARS-CoV-2 N-Protein IgG Antibody (SARS-CoV-2 N IgG) ELISA Kit Plasma, Serum Quantitative Indirect ELISA ABIN6952772 element-ABIN6952772
SARS-CoV-2 N-Protein IgG Antibody (SARS-CoV-2 N IgG) ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952759 element-ABIN6952759
SARS-CoV-2 N-Protein IgG Antibody (SARS-CoV-2 N IgG) ELISA Kit Nasal Secretions, Plasma, Saliva, Serum Qualitative Sandwich ELISA ABIN6952770 element-ABIN6952770
SARS-CoV-2 N-Protein IgM Antibody (SARS-CoV-2 N IgM) ELISA Kit Nasal Secretions, Plasma, Saliva, Serum Qualitative Sandwich ELISA ABIN6952771 element-ABIN6952771
SARS-CoV-2 N-Protein IgM Antibody (SARS-CoV-2 N IgM) ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952760 element-ABIN6952760
SARS-CoV-2 S-Protein IgG Antibody ELISA Kit Serum Qualitative Sandwich ELISA ABIN6952774 element-ABIN6952774
SARS-CoV-2 S1 Subunit (RBD) IgA Antibody ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952761 element-ABIN6952761
SARS-CoV-2 S1 Subunit (RBD) IgG Antibody ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952815 element-ABIN6952815
SARS-CoV-2 S1 Subunit (RBD) IgM Antibody ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952763 element-ABIN6952763

SARS-CoV-2 Spike (S) Protein ELISA Kits

Product Sample Type Analytical Method Cat. No. Relevance ProductGrid: uniqueid
SARS-CoV-2 Spike ELISA Kit Cell Culture Supernatant, Plasma, Serum Quantitative Sandwich ELISA ABIN6952757 element-ABIN6952757
SARS-CoV-2 S1 Subunit (RBD) IgM Antibody ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952763 element-ABIN6952763
SARS-CoV-2 S1 Subunit (RBD) IgG Antibody ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952815 element-ABIN6952815
SARS-CoV-2 S1 Subunit (RBD) IgA Antibody ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952761 element-ABIN6952761
SARS-CoV-2 S-Protein IgG Antibody ELISA Kit Serum Qualitative Sandwich ELISA ABIN6952774 element-ABIN6952774
SARS-CoV-2 Inhibitor Screening Kit ABIN6952717 element-ABIN6952717
SARS-CoV-2 antibody titer assay kit (Spike protein S1) ABIN6952713 element-ABIN6952713
SARS-CoV-2 antibody titer assay kit (Spike protein RBD) ABIN6952714 element-ABIN6952714
COVID-19 Spike-ACE2 Binding Assay Kit Plasma, Serum Semi-Quantitative ABIN6952755 element-ABIN6952755

SARS-CoV-2 Nucleocapsid (N) Protein ELISA Kits

Product Sample Type Analytical Method Cat. No. Relevance ProductGrid: uniqueid
SARS-CoV-2 N-Protein Antibody ELISA Kit Nasal Secretions, Plasma, Saliva, Serum Qualitative Sandwich ELISA ABIN6952781 element-ABIN6952781
SARS-CoV-2 N-Protein IgA Antibody ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952758 element-ABIN6952758
SARS-CoV-2 N-Protein IgG Antibody (SARS-CoV-2 N IgG) ELISA Kit Plasma, Serum Qualitative Indirect ELISA ABIN6952662 element-ABIN6952662
SARS-CoV-2 N-Protein IgG Antibody (SARS-CoV-2 N IgG) ELISA Kit Plasma, Serum Quantitative Indirect ELISA ABIN6952772 element-ABIN6952772
SARS-CoV-2 N-Protein IgG Antibody (SARS-CoV-2 N IgG) ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952759 element-ABIN6952759
SARS-CoV-2 N-Protein IgG Antibody (SARS-CoV-2 N IgG) ELISA Kit Nasal Secretions, Plasma, Saliva, Serum Qualitative Sandwich ELISA ABIN6952770 element-ABIN6952770
SARS-CoV-2 N-Protein IgM Antibody (SARS-CoV-2 N IgM) ELISA Kit Nasal Secretions, Plasma, Saliva, Serum Qualitative Sandwich ELISA ABIN6952771 element-ABIN6952771
SARS-CoV-2 N-Protein IgM Antibody (SARS-CoV-2 N IgM) ELISA Kit Plasma, Serum Semi-Quantitative Indirect ELISA ABIN6952760 element-ABIN6952760
SARS-CoV-2 Nucleocapsid ELISA Kit (SARS-CoV-2 N) Cell Culture Supernatant, Cell Extracts Quantitative Sandwich ELISA ABIN6952543 element-ABIN6952543
SARS-CoV-2 Nucleocapsid ELISA Kit (SARS-CoV-2 N) Cell Culture Supernatant, Serum Quantitative Sandwich ELISA ABIN6952756 element-ABIN6952756
SARS-CoV-2 Nucleocapsid ELISA Kit (SARS-CoV-2 N) Cell Culture Lysate, Cell Culture Supernatant, Nasal Secretions, Plasma, Serum, Throat Swab, Tissue Homogenate Quantitative Sandwich ELISA ABIN6952782 element-ABIN6952782

More SARS-CoV-2 Kits

Product Sample Type Cat. No. Relevance ProductGrid: uniqueid
COVID-19 Spike-ACE2 Binding Assay Kit Plasma, Serum ABIN6952755 element-ABIN6952755
SARS-CoV-2 Inhibitor Screening Kit ABIN6952717 element-ABIN6952717

References

  1. Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y et al. (2020) "Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease." Pre-print medRxiv 2020.03.02.20030189.
  2. Haveri A, Smura T, Kuivanen S, Österlund P, Hepojoki J, Ikonen N, et al. (2020) "Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February." Euro Surveill 25(11):2000266.
  3. Gao T et al. (2020): "Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation." medRxiv,
  4. Risitano AM et al. (2020): “Complement as a target in COVID-19?” Nature Reviews Immunology, 65(12): 1337-45