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Human Monoclonal CXCL1 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900740
Meen, Øynebråten, Reine, Duelli, Svennevig, Pejler, Jenssen, Kolset: Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. in The Journal of biological chemistry 2011
Show all 5 Pubmed References
Human Polyclonal CXCL1 Primary Antibody for WB - ABIN3044150
Xu, Zhu, Zhang, Tian, Zhang, Wu, Gao: NF?B-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice. in Journal of neuroinflammation 2014
Show all 4 Pubmed References
Mouse (Murine) Polyclonal CXCL1 Primary Antibody for ELISA, WB - ABIN5693092
Zhang, Cao, Zhang, Ji, Gao: Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons. in Pain 2013
Show all 4 Pubmed References
Mouse (Murine) Polyclonal CXCL1 Primary Antibody for IF (p), IHC (p) - ABIN2173443
Ito, Katano, Kawai, Yagoto, Takahashi, Ka, Ogura, Takahashi, Ito: A Novel Xenogeneic Graft-Versus-Host Disease Model for Investigating the Pathological Role of Human CD4(+) or CD8(+) T Cells Using Immunodeficient NOG Mice. in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016
Rat (Rattus) Polyclonal CXCL1 Primary Antibody for Func, ELISA - ABIN2473131
Vallès, Grijpink-Ongering, de Bree, Tuinstra, Ronken: Differential regulation of the CXCR2 chemokine network in rat brain trauma: implications for neuroimmune interactions and neuronal survival. in Neurobiology of disease 2006
Human Monoclonal CXCL1 Primary Antibody for FACS, IHC (fro) - ABIN151355
Traister, Patel, Huang, Patel, Plakhotnik, Lee, Medina, Welsh, Ruparel, Zhang, Friedberg, Maynes, Coles: Cardiac regenerative capacity is age- and disease-dependent in childhood heart disease. in PLoS ONE 2018
Mouse (Murine) Polyclonal CXCL1 Primary Antibody for IHC (fro), IP - ABIN549332
Gavard, Hou, Qu, Masedunskas, Martin, Weigert, Li, Gutkind: A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability. in Molecular and cellular biology 2009
Human Polyclonal CXCL1 Primary Antibody for ELISA - ABIN4274952
Kawanishi, Matsui, Ito, Watanabe, Takahashi, Nishizawa, Nishiyama, Kamoto, Mikami, Tanaka, Jung, Akiyama, Nobumasa, Guilford, Reeve, Okuno, Tsujimoto, Nakamura, Ogawa: Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Both GRO-alpha and IL-8 can activate TAK1/NFkappaB signaling via the CXCR2 receptor.
Results show that the expression of CXCL1 and CXCL2 in tumor cells and tumor-infiltrated CD11b+ myeloid cells is critically involved in the promotion of the generation of monocytic myeloid-derived suppressor cells (mo-MDSC) from bone marrow cells. CXCL1 and CXCL2 were found to specifically promote the expansion of mo-MDSC rather than granulocytic MDSC (G-MDSC).
The chemokine Gro1 induced in response to inflammation triggers senescence and arrests development of new neurons in the hippocampus and that the magnitude of this response is sex-dependent.
CXCL1 displays a specific microRNA (miR) upregulated by the prototypical colon cancer onco-miR miR-105.
These results show that AKIP1 is crucial in cervical cancer angiogenesis and growth by elevating the levels of the NF-kappaB-dependent chemokines CXCL1, CXCL2, and CXCL8.
Adipose stromal cells recruitment to tumours, driven by CXCL1 and CXCL8, promotes prostate cancer progression.
CXCL1, which is produced by breast cancer cells, can promote cancer growth and development
miR-204 inhibits cell proliferation in gastric cancer by targeting CKS1B, CXCL1 and GPRC5A.
Thrombocytosis was more prevalent in patients with inflammatory breast cancer (IBC)than in those with non-IBC and it was associated with poor prognosis. GRO and TGF-beta were associated with thrombocytosis in IBC
the plasma concentrations of CXCL1 indicated the disease activity and prognosis in interstitial pneumonia with autoimmune features (IPAF). Thus, the CXCL1/CXCR2 axis appears to be involved in the progression of IPAF.
CXCL1/8 secreted by adipose-derived mesenchymal stem cells could promote breast cancer angiogenesis.
GROA overexpression is associated with invasion in triple negative breast cancer.
The results of the transwell chemotaxis assay also supported the above results. Our data suggest that APN can promote h-JBMMSC chemotaxis by up-regulating CXCL1 and CXCL8
This study highlighted CAF-secreted CXCL1 as an attractive target to reverse tumor radioresistance.
we identified the microRNA miR-200a as a putative post-transcriptional regulator of CXCL1 in hepatocellular carcinoma
study demonstrates that CXCL1 can transform NOFs into senescent CAFs via an autocrine mechanism
Association of polymorphic markers of chemokine genes, their receptors, and CD14 gene with coronary atherosclerosis
GROalpha high in the tumor microenvironment can be used as potential indicators for the progression of non-small cell lung cancer
IL-8, but not the CXCL1 circuit, is critical for the regulation of thyroid cancer stem cells.
this study shows that CXCL1 is expressed in epithelium of the endometrium with adenomyosis and demonstrate that VEGF is capable of inducing CXCL1 expression
CXCL1, CXCL2 and CCL2 binding to the glomerular endothelial glycocalyx appears differentially mediated by specific Heparan sulfate domains.
The increase of C-X-C motif chemokine ligand (cxcl)-1 gene expression was statistically significant at 2 days and 2 wks after injury.
Data suggest that CD4+ T lymphocytes and microglial CD40 mediate their pro-nociceptive effects in part by promoting selected chemokine responses, and more importantly, CXCL1 can play an anti-nociceptive role in peripheral nerve injury-induced neuropathic pain, which is possibly mediated by infiltrating neutrophils.
The results demonstrate that C57BL/6J mice have a functional defect in NLRP12, impaired CXCL1 production, and that macrophages require NLRP12 expression for effective recruitment of neutrophils to inflammatory sites.
GAG interactions and receptor activity of CXCL1 monomers and dimers are fine-tuned to regulate neutrophil trafficking for successful resolution of tissue injury.
a paracrine role for Hippo-mediated secretion of CXCL1 and CXCL2 in the production of anti-microbial peptides (beta-defensins), iNOS, NOX2 and pro-inflammatory molecules during mycobacterial infection of the host, is reported.
this study demonstrates that in vivo blocking of CXCL1 and CXCL2 can significantly reduce the Mycobacterium tuberculosis-induced bioactive IL-1beta production
RelA has a role in regulating OIS in preneoplastic lesions; the RelA/CXCL1/CXCR2 axis is an essential mechanism of tumor surveillance in pancreatic ductal adenocarcinoma
CXCL1 contributed to rapid neutrophil recruitment during Bacillus cereus endophthalmitis. In CXCL1-knockout mice, retinal function was greater and neutrophil influx was less than in control mice, confirming its role in ocular inflammation.
Interferon-gamma (IFN-gamma) up-regulated interleukin 6 (IL-6) and CXCL1 chemokine (CXCL1) production of bone marrow mesenchymal stem cells (mBM-MSC).
Our work deciphers the mCXCL1-mTORC1 pathway as crucial in liver cancer stem cell maintenance
MMP7 shedding of syndecan-1/CXCL1 complexes functions as a checkpoint that restricts neutrophil activation at sites of epithelial injury.
Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 and (C-X-C motif) ligand 1 (CXCL1).
CXCR2/CXCL1 axis promotes granulocytic myeloid-derived suppressor cells recruitment and facilitates arginase I expression and activity of these cells at maternal-fetal interface
The novel findings reveal the critical role of NLRP12-IL-17A-CXCL1 axis in host defense by modulating neutrophil recruitment against Klebsiella pneumoniae.
Nlrp12 deficiency caused increased neutrophil migration towards the chemokine CXCL1 and the neutrophil parasite Leishmania major, revealing NLRP12 as a negative regulator of directed neutrophil migration under these conditions.
CXCL1 monomer-dimer distribution and receptor interactions are highly coupled and regulate neutrophil trafficking and that injury in the context of disease is a consequence of inappropriate CXCR2 activation
Chemotactic activity of stellate cell-derived CXCL1 was assayed in vitro on neutrophils upon TLR4 activation.
IL-17RA regulates CXL-1 and 5 production in the lungs during the adaptive response.
This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4.
C-X-C motif chemokine 1
, GRO1 oncogene (melanoma growth stimulating activity, alpha)
, GRO1 oncogene (melanoma growth-stimulating activity)
, MGSA alpha
, fibroblast secretory protein
, growth-regulated alpha protein
, melanoma growth stimulatory activity alpha
, neutrophil-activating protein 3
, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
, cytokine-induced neutrophil chemoattractant 1
, platelet-derived growth factor-inducible protein KC
, chemokine CXCL1/GRO-ALPHA
, melanoma growth stimulatory activity homolog
, growth related gene 1
, growth-regulated protein homolog alpha
, GRO1 oncogene
, secretory protein N51
, growth regulated protein GRO
, growth regulated