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anti-Human LAMP1 Antibodies:
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Human Polyclonal LAMP1 Primary Antibody for ICC, IF - ABIN266767
Ishikawa, Ma, Barber: STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. in Nature 2009
Show all 18 Pubmed References
Human Monoclonal LAMP1 Primary Antibody for FACS, ICC - ABIN638445
Mane, Marzella, Bainton, Holt, Cha, Hildreth, August: Purification and characterization of human lysosomal membrane glycoproteins. in Archives of biochemistry and biophysics 1989
Show all 9 Pubmed References
Human Monoclonal LAMP1 Primary Antibody for FACS, ICC - ABIN638446
Furuta, Ikeda, Nakayama, Nakamura, Tanaka, Hamasaki, Himeno, Hamilton, August: Expression of lysosome-associated membrane proteins in human colorectal neoplasms and inflammatory diseases. in The American journal of pathology 2001
Show all 9 Pubmed References
Human Monoclonal LAMP1 Primary Antibody for IHC (f), ICC - ABIN1027703
Mao, Tu, Liu, Qin, Zheng, Chan, Lam, Peiris, Lau: Inhibition of human natural killer cell activity by influenza virions and hemagglutinin. in Journal of virology 2010
Show all 8 Pubmed References
Human Polyclonal LAMP1 Primary Antibody for IF, IHC (p) - ABIN388566
Sawada, Jardine, Fukuda: The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes. in The Journal of biological chemistry 1993
Show all 5 Pubmed References
Human Polyclonal LAMP1 Primary Antibody for ICC, IF - ABIN4330169
Edwards, Rockx-Brouwer, Nair, Celli: Restricted cytosolic growth of Francisella tularensis subsp. tularensis by IFN-gamma activation of macrophages. in Microbiology (Reading, England) 2010
Show all 4 Pubmed References
Mouse (Murine) Monoclonal LAMP1 Primary Antibody for IAC, IHC (fro) - ABIN967382
Arterburn, Earles, August: The disulfide structure of mouse lysosome-associated membrane protein 1. in The Journal of biological chemistry 1990
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Human Polyclonal LAMP1 Primary Antibody for FACS, IF (cc) - ABIN676088
Jeong, Lee, Yang, Seong: Combination of macrophage inflammatory protein 1 alpha with existing therapies to enhance the antitumor effects on murine hepatoma. in Journal of radiation research 2014
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Human Monoclonal LAMP1 Primary Antibody for CyTOF, FACS - ABIN4900070
Sasaki, Hidaka, Ueno, Akiba-Takagi, Oliva Trejo, Seki, Nagai-Hosoe, Tanaka, Horikoshi, Tomino, Suzuki, Asanuma: Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte. in Scientific reports 2017
Show all 3 Pubmed References
Mouse (Murine) Polyclonal LAMP1 Primary Antibody for CyTOF, FACS - ABIN4899902
Zhang, Johnson, He, Napolitano, Ramadass, Rocca, Kiosses, Bucci, Xin, Gavathiotis, Cuervo, Cherqui, Catz: Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. in The Journal of biological chemistry 2017
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LIN28A inhibits lysosomeassociated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells.
A novel data on LAMP-1 overexpression in high grade glioma are presented suggesting involvement of this gene and protein in cell adhesion and tumor progression.
LAMP1 is involved in the TNM stages and histological differentiation of the esophageal squamous cell carcinoma
LAMP1 has a role in fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens
Impaired autophagic pathways were further shown by analyzing late autophagic vesicles; immunostaining with lysosome-associated membrane protein 1 (LAMP-1) antibody revealed enlarged and annular LAMP-1-positive organelles in AMD retinal pigment epithelium (RPE)as opposed to smaller discrete puncta observed in normal RPE
The authors show here that human LAMP1 and LAMP2 bind cholesterol in a manner that buries the cholesterol 3beta-hydroxyl group; they also bind tightly to NPC1 and NPC2 proteins that export cholesterol from lysosomes.
downregulation of FUT1, which leads to the perinuclear localization of LAMP-1 and 2, is correlated with increased rate of autophagic flux by decreasing mTOR signaling and increasing autolysosome formation.
the assembly modes of LAMP-1 and LAMP-2 are different, which may underlie their distinct functions
Overexpression of LAMP1 was observed in prostate cancer (PCa) and castration-resistant prostate cancer clinical specimens. Moreover, downstream pathways were identified using si-LAMP1-transfected cells. The discovery of tumor-suppressive miR320a-mediated pathways may provide important insights into the potential mechanisms of PCa metastasis.
The data implied that high LAMP1 expression is associated with unfavourable prognosis in laryngeal squamous cell carcinoma patients, and LAMP1 may be identified as a novel prognostic biomarker
The data support a viral entry mechanism dependent on binding to the lysosome-resident receptor LAMP1 and further dissociation of the membrane-distal GP1 subunits.
A unique triad of histidines of Lassa Virus GP1 forms a binding site for host LAMP1.
The LAMP-1 had preferential localization in the high density secondary lysosomes where endogenous human LAMP-1 was enriched. In contrast, a major portion of I382L was located in a low density fraction.
Downregulation of miR-184 was consistent with significantly lower levels of LAMP-1
Human miR-373 is silenced by histone modification in lung cancer cells and is a negative regulator of the mesenchymal phenotype through downstream IRAK2 and LAMP1 target genes.
Synergistic defects of different molecules in the cytotoxic pathway lead to clinical familial hemophagocytic lymphohistiocytosis.
Caveolin-1 associated adenovirus entry into human corneal cells.
study has shown that Lassa virus entry requires a pH-regulated engagement of alpha-DG and LAMP1 both of which need to be glycosylated
in TB pleurisy regulatory T lymphocytes effectively inhibit CD107a expression
LAMP-1 and LAMP-2 could be used as additional markers with which to assess enzyme replacement therapy effectiveness in Fabry disease.
larger autophagic vacuoles that colocalize with early endosome antigen 1 (EEA1) but not with lysosomal-associated membrane protein (LAMP)-1 were much more frequently formed in Rab7(Deltapan) pancreatic acinar cells.
Both LAMP-1 and LAMP-2 are involved in C2C12 myotube formation and LAMP-2 may contribute dominantly to it.
A recombinant DNA vaccine, pVAX-LAMP/Gn was previously proved efficient, requiring long-term evaluations. pVAX-LAMP/Gn established memory responses within a long-term protection. Lysosome-targeted strategy showed promise on Gn-based DNA vaccine and further investigations are warranted in other immunogenic Hantaviral antigens.
The results presented here show the major role of LAMP-2 in caveolin traffic and membrane repair and consequently in T. cruzi invasion.
Here, we identify lamellar inclusions as the subcellular site of lipid accumulation in neurons, we uncover a vicious cycle of cholesterol synthesis and accretion, which may cause gradual neurodegeneration, and we reveal how beta-cyclodextrin, a potential therapeutic drug, reverts these changes. Our study provides new mechanistic insight in NPC disease and uncovers new targets for therapeutic approaches.
we demonstrate that galectin-3 induces MMP9 expression via p38 MAP-kinase pathway. LAMP1 was demonstrated to serve as one of the key mediators of galectin-3-induced MMP9 expression via p38 MAPK pathway
Although surface LAMP1 promotes interactions with organ ECM and BM, carbohydrates on LAMP1 play a decisive role in dictating lung metastasis.
LAMP luminal domain also showed to be essential for Gag traffic through lysosomes.
The results thus for the first time provide direct evidence that cell surface LAMP1 facilitates lung metastasis by providing ligands for galectin-3 which has been shown to be expressed in highest amounts on lungs and constitutively on its vascular endothelium.
CD107a/LAMP-1 has a role in the protection of NK cells from degranulation-associated suicide
LAMP proteins retain TAPL on the limiting membrane of endosomes and prevent its sorting to intraluminal vesicles.
a novel mechanism showing how Salmonella acquires LAMP1 through a SipC-Syntaxin6-mediated interaction probably to stabilize their niche in macrophages
The kinetic observations provide sufficient quantitative evidence that in P338D(1) cells the bulk of newly-synthesized endogenous LAMP-1 first appeared in early endosomes, before it was delivered to late endosomes and lysosomes about 25 min later.
The finding raises the possibility that the expression of SSEA-1-positive LAMP-1 is associated with the "stemness" of neural stem cells.
Using LAMP1/2 knock out cells the authors show that these two proteins are important for Trypanosoma cruzi infection of host cells, both in entrance and intracellular development, conceivably by being the major source of sialic acid for Trypanosoma cruzi.
LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts
Our results suggested that the increase in LAMP-1 was enhanced by the accumulation of amyloid-beta occurring during aging. Our findings coincided with the pathological hallmarks of Alzheimer's disease.
A study of the expression of BECN1, LC3-II, and LAMP1 throughout the luteal phase of the estrous cycle in order to assess autophagy during corpus luteum development is reported.
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis.
CD107 antigen-like family member A
, lysosome-associated membrane glycoprotein 1
, lysosome-associated membrane protein 1
, 120 kDa lysosomal membrane glycoprotein
, LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B)
, Lamp I
, lysosomal membrane glycoprotein 1
, lysosomal membrane glycoprotein A
, Lysosomal associated membrane protein 1 (120 kDa)
, lysosome membrane glycoprotein LEP100
, chromaffin granule-associated membrane glycoprotein IIA
, glycoprotein IIa
, Lysosomal membrane glycoprotein A
, Lysosome-associated membrane protein 1
, lysosomal-associated membrane protein 1 L homeolog