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anti-Human Thrombospondin 1 Antibodies:
anti-Mouse (Murine) Thrombospondin 1 Antibodies:
anti-Rat (Rattus) Thrombospondin 1 Antibodies:
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Cow (Bovine) Monoclonal Thrombospondin 1 Primary Antibody for BP, ICC - ABIN151527
Cupi, Sarra, De Nitto, Franzè, Marafini, Monteleone, Del Vecchio Blanco, Paoluzi, Di Fusco, Gentileschi, Ortenzi, Colantoni, Pallone, Monteleone: Defective expression of scavenger receptors in celiac disease mucosa. in PLoS ONE 2014
Show all 4 Pubmed References
Human Polyclonal Thrombospondin 1 Primary Antibody for ELISA, WB - ABIN4359279
Pan, Chang, Chuang, Hung: The nonsteroidal anti-inflammatory drug NS398 reactivates SPARC expression via promoter demethylation to attenuate invasiveness of lung cancer cells. in Experimental biology and medicine (Maywood, N.J.) 2008
Our findings suggest that Rab37 (show RAB37 Antibodies)-mediated TSP1 secretion in cancer cells suppresses metastasis and angiogenesis via a cross-talk with endothelial cells and reveal a novel component of the vesicular exocytic machinery in tumor microenvironment and tumor progression
TSP-1 strongly potentiated the proliferative and migratory activity of PDGF (show PDGFA Antibodies) on mesenchymal stromal cells.
This study demonstrated that THBS! was detected in the serums of Alzheimer disease patients.
Functional studies showed THBS1 and TNC (show TNC Antibodies) to mediate chemoresistance through the integrin beta1/mTOR (show FRAP1 Antibodies) pathway.
These findings shed light on the mechanisms leading to beta-cell failure during metabolic stress and point to THBS1 as an interesting therapeutic target to prevent oxidative stress in type 2 diabetes.
Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.
High plasma levels of TSP-1 are associated with increased pulmonary arterial pressure, increased pulmonary vascular resistance and decreased survival pulmonary hypertension.
Our data suggest that the molecular network including TSP-1, TGF-beta1 (show TGFB1 Antibodies), and PGE2 might be involved in the pathogenesis of acute angle closure glaucoma.
Genetic variants of THBS1 were significantly more frequent in patients affected by idiopathic/genetic generalized epilepsies than in non-epileptic controls.
In pulmonary hypertension TSP1-CD47 (show CD47 Antibodies) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
In a laser injury-induced thrombosis model, P-selectin (show SELP Antibodies) modulates thrombus propagation independently of VWF (show VWF Antibodies) and TSP1 (show GZMA Antibodies)
cultured astrocytes isolated from an Fmr1 (show FMR1 Antibodies) knockout (Fmr1 (show FMR1 Antibodies) KO) mouse model of Fragile X (show FMR1 Antibodies) syndrome displayed a significant decrease in TSP-1 (show GZMA Antibodies) protein expression compared to the wildtype (WT) astrocytes.
In pulmonary hypertension TSP1 (show GZMA Antibodies)-CD47 (show CD47 Antibodies) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
HIF-1alpha (show HIF1A Antibodies) induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (show MLXIP Antibodies)-21 via inhibiting a novel target gene TSP-1 (show GZMA Antibodies). Both of them may contribute to the protective effect of HIF-1alpha (show HIF1A Antibodies) on renal I/R injury.
the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (show GZMA Antibodies)/CD47 (show CD47 Antibodies) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
TSP-1 (show GZMA Antibodies) deficiency promotes maladaptive remodelling of the ECM (show MMRN1 Antibodies) leading to accelerated abdominal aortic aneurysms progression.
TSP-1 (show GZMA Antibodies) suppressed insulin (show INS Antibodies) signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK (show MAPK8 Antibodies), p38 (show CRK Antibodies), and IKK (show CHUK Antibodies).
Three transcription factors were overexpressed and eleven underexpressed in TSP1 (show GZMA Antibodies)(-/-) compared to WT LGs (show LGSN Antibodies).
Data indicate that thrombospondin-1 may contribute to a destructive macrophage response in dysferlinopathy and pose the intriguing possibility that thrombospondin-1 levels may serve as a biomarker for disease progression.
Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (show THBS2 Antibodies) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (show THBS2 Antibodies), up-regulates expression of FGF2 (fibroblast growth factor 2 (show FGF2 Antibodies)).
Thrombospondin has a role in inducing RhoA (show RHOA Antibodies) inactivation through FAK (show PTK2 Antibodies)-dependent signaling to stimulate focal adhesion disassembly
Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (show INS Antibodies)-like growth factor
The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications
The novel finding that TSP-1-induced migration is dependent on the CD44 (show CD44 Antibodies) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (show KDM5D Antibodies)).
These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (show IGF1 Antibodies) and the mechanisms by which hyperglycemia regulates TSP-1 protein.
Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (show TGFB1 Antibodies) expression.
ELL (show ELL Antibodies) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
, thrombospondin 1
, thrombospondin 2