Browse our anti-Thrombospondin 1 (THBS1) Antibodies

Human Thrombospondin 1 (THBS1) interaction partners

1. TSP-1 effectively elevated P. gingivalis LPS (show IRF6 Antibodies)-induced inflammation mediated by the NF-kappaB (show NFKB1 Antibodies) pathway and may be critical for pathology of periodontitis.

2. These findings indicate that PRR13 (show PRR13 Antibodies)/THBS1 and TXN (show TXN Antibodies) expression could be used for the prediction of resistance to treatment of epithelial ovarian cancer patients.

3. TSP-1 appears to play an accessory role in modulating Mp activity in humans and BlaJ mice in a gender, age and muscle-dependent manner, but is unlikely a primary driver of disease progression of dysferlinopathy.

4. TSP-4 (show THBS4 Antibodies) A387P polymorphism, but not TSP-1 polymorphism, is an independent risk factor for acute myocardial infarction in Egyptians.

5. Results show that the thrombospondin 1 (TSP1) and its receptor CD47 (CD47 (show CD47 Antibodies)) axis selectively regulates NADPH oxidase 1 (Nox1 (show NOX1 Antibodies)) in the regulation of endothelial senescence and suggest potential targets for controlling the aging process at the molecular level.

6. 15-LOX-1 expression in colon and prostate cancer cells leads to reduced angiogenesis. These changes could be mediated by an increase in the expression of both ICAM-1 and the anti-angiogenic protein TSP-1.

7. miR (show MLXIP Antibodies)-98 can suppress the expression of TSP1 in the peripheral B cells of patients with allergic asthma.

8. Data indicate correlation between the levels of thrombospondin-1 and overall survival of ovarian cancer patients, suggesting thrombospondin-1 may be used as a prognostic factor in ovarian cancer patients.

9. Studies show that thrombospondin-1 (Thbs-1), is a prolific contributor to the production and modulation of ROS (show ROS1 Antibodies) in large conductance vessels and in the peripheral circulation. Recently, the presence of physiologically relevant circulating Thbs-1 levels was proven to also disrupt vasodilation to nitric oxide (NO) in coronary arterioles from aged animals, negatively impacting coronary blood flow reserve. [review]

10. Our findings suggest that Rab37 (show RAB37 Antibodies)-mediated TSP1 secretion in cancer cells suppresses metastasis and angiogenesis via a cross-talk with endothelial cells and reveal a novel component of the vesicular exocytic machinery in tumor microenvironment and tumor progression

Mouse (Murine) Thrombospondin 1 (THBS1) interaction partners

1. TSP-1 (show GZMA Antibodies) appears to play an accessory role in modulating Mp activity in humans and BlaJ mice in a gender, age and muscle-dependent manner, but is unlikely a primary driver of disease progression of dysferlinopathy.

2. TSP-1 (show GZMA Antibodies) may be beneficial for maintaining BBB (show ALMS1 Antibodies) integrity in the early phase and functional recovery in late phase after traumatic brain injury.

3. In a laser injury-induced thrombosis model, P-selectin (show SELP Antibodies) modulates thrombus propagation independently of VWF (show VWF Antibodies) and TSP1 (show GZMA Antibodies)

4. These findings shed light on the mechanisms leading to beta-cell failure during metabolic stress and point to THBS1 as an interesting therapeutic target to prevent oxidative stress in type 2 diabetes.

5. cultured astrocytes isolated from an Fmr1 (show FMR1 Antibodies) knockout (Fmr1 (show FMR1 Antibodies) KO) mouse model of Fragile X (show FMR1 Antibodies) syndrome displayed a significant decrease in TSP-1 (show GZMA Antibodies) protein expression compared to the wildtype (WT) astrocytes.

6. In pulmonary hypertension TSP1 (show GZMA Antibodies)-CD47 (show CD47 Antibodies) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.

7. HIF-1alpha (show HIF1A Antibodies) induced angiogenesis by upregulating not only vascular endothelial growth factor (show VEGF Antibodies) but also miR (show MLXIP Antibodies)-21 via inhibiting a novel target gene TSP-1 (show GZMA Antibodies). Both of them may contribute to the protective effect of HIF-1alpha (show HIF1A Antibodies) on renal I/R injury.

8. the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (show GZMA Antibodies)/CD47 (show CD47 Antibodies) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.

9. TSP-1 (show GZMA Antibodies) deficiency promotes maladaptive remodelling of the ECM (show MMRN1 Antibodies) leading to accelerated abdominal aortic aneurysms progression.

10. TSP-1 (show GZMA Antibodies) suppressed insulin (show INS Antibodies) signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK (show MAPK8 Antibodies), p38 (show CRK Antibodies), and IKK (show CHUK Antibodies).

Cow (Bovine) Thrombospondin 1 (THBS1) interaction partners

1. Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (show THBS2 Antibodies) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (show THBS2 Antibodies), up-regulates expression of FGF2 (fibroblast growth factor 2 (show FGF2 Antibodies)).

2. Thrombospondin has a role in inducing RhoA (show RHOA Antibodies) inactivation through FAK (show PTK2 Antibodies)-dependent signaling to stimulate focal adhesion disassembly

3. Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF (show VEGFA Antibodies) was inversely expressed, with expression increasing as follicles developed.

4. Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (show INS Antibodies)-like growth factor

5. The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications

6. The novel finding that TSP-1-induced migration is dependent on the CD44 (show CD44 Antibodies) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (show KDM5D Antibodies)).

Pig (Porcine) Thrombospondin 1 (THBS1) interaction partners

1. These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (show IGF1 Antibodies) and the mechanisms by which hyperglycemia regulates TSP-1 protein.

2. Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (show TGFB1 Antibodies) expression.

Zebrafish Thrombospondin 1 (THBS1) interaction partners

1. ELL (show ELL Antibodies) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation