(Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011].
custom-made
TNFSF13B
Origin: Mouse
Host: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
Catalog No. ABIN3120051
-15% Promotion 2026
Starts at
$17,408.48
$20,480.57
save $3,072.09 (-15 %)
Plus shipping costs $50.00, if applicable $20.00 dry ice
custom-made
TNFSF13B
Origin: Human
Host: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
SDS, WB, ELISA
Catalog No. ABIN3119280
-15% Promotion 2026
Starts at
$17,408.48
$20,480.57
save $3,072.09 (-15 %)
Plus shipping costs $50.00, if applicable $20.00 dry ice
TNFSF13B
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 95 % as determined by SDS-PAGE and Coomassie blue staining
Func, AbP, STD, PI
Active
TNFSF13B
Origin: Human
Host: HEK-293 Cells
Recombinant
The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Huard, Tran, Benkhoucha, Manzin-Lorenzi, Santiago-Raber: "Selective APRIL blockade delays systemic lupus erythematosus in mouse." in: PLoS ONE, Vol. 7, Issue 2, pp. e31837, (2012) (PubMed).
Bossen, Tardivel, Willen, Fletcher, Perroud, Beermann, Rolink, Scott, Mackay, Schneider: "Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses." in: European journal of immunology, Vol. 41, Issue 3, pp. 787-97, (2011) (PubMed).
Bossen, Cachero, Tardivel, Ingold, Willen, Dobles, Scott, Maquelin, Belnoue, Siegrist, Chevrier, Acha-Orbea, Leung, Mackay, Tschopp, Schneider: "TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts." in: Blood, Vol. 111, Issue 3, pp. 1004-12, (2008) (PubMed).
Kern, Cornuel, Billard, Tang, Rouillard, Stenou, Defrance, Ajchenbaum-Cymbalista, Simonin, Feldblum, Kolb: "Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway." in: Blood, Vol. 103, Issue 2, pp. 679-88, (2004) (PubMed).