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anti-Human Calcitonin Receptor Antibodies:
anti-Rat (Rattus) Calcitonin Receptor Antibodies:
anti-Mouse (Murine) Calcitonin Receptor Antibodies:
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Human Monoclonal Calcitonin Receptor Primary Antibody for CyTOF, FACS - ABIN4899906
Costa-Rodrigues, Teixeira, Sampaio, Fernandes: Characterisation of the osteoclastogenic potential of human osteoblastic and fibroblastic conditioned media. in Journal of cellular biochemistry 2009
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Mouse (Murine) Polyclonal Calcitonin Receptor Primary Antibody for IF (p), IHC (p) - ABIN725330
Su, Gu, Dong, Mei: Ibuprofen rescues abnormalities in periodontal tissues in conditional presenilin 1 and presenilin 2 double knockout mice. in International journal of molecular sciences 2013
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Human Monoclonal Calcitonin Receptor Primary Antibody for IHC (fro), FACS - ABIN2477841
Sorenson: Effects of nonmineral tissues on measurement of bone mineral content by dual-photon absorptiometry. in Medical physics 1990
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Dasyatis sabina (Atlantic stingray) Polyclonal Calcitonin Receptor Primary Antibody for IHC (fro), IF - ABIN2477845
Nayak, Misra, Mulé: Physiological disposition and biotransformation of (3H) cocaine in acutely and chronically treated rats. in The Journal of pharmacology and experimental therapeutics 1976
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Human Monoclonal Calcitonin Receptor Primary Antibody for ELISA, WB - ABIN513951
Segovia-Silvestre, Bonnefond, Sondergaard, Christensen, Karsdal, Bay-Jensen: Identification of the calcitonin receptor in osteoarthritic chondrocytes. in BMC research notes 2011
Human Polyclonal Calcitonin Receptor Primary Antibody for ELISA, IHC - ABIN6260409
Xu, Shi, Xu, Gu, Fu, Zhang, Cheng, Jiang: Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity. in Journal of tissue engineering and regenerative medicine 2018
Human Polyclonal Calcitonin Receptor Primary Antibody for EIA, IHC (p) - ABIN121621
Tolcos, Tikellis, Rees, Cooper, Wookey: Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat. in The Journal of comparative neurology 2002
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These results suggest that CT acts as a hypocalcemic factor in calcium regulation, probably through inhibition of ECaC synthesis.
crlr plays a nonredundant role in arterial differentiation, representing a novel element of the sonic hedgehog-vegf-notch signaling cascade that controls arterial/venous fate
CTR activates AKAP2-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 and claudin 3.
structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Galphasbetagamma protein determined by Volta phase-plate single-particle cryo-electron microscopy
Data suggest that a single GlcNAc residue at CTR N130 (asparagine 130) is responsible for enhanced affinity of calcitonin for CTR ECD; the same appears to apply for enhanced affinity of amylin for RAMP2-CTR ECD. [GlcNAc = N-acetylglucosamine; CTR = calcitonin receptor; ECD = extracellular domain; RAMP2 = receptor (calcitonin) activity modifying protein 2].
Males with CALCR TT genotype (rs1801197) have 13 fold increased risk for kidney stone disease. No significant association of rs1042138 with kidney stone in West Bengal, India.
Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.
An association between fluorosis and the Alu I polymorphism in the CTR gene was observed in fluoride-exposed populations.
The C1377T polymorphism in the CTR gene is associated with bone mineral density at the lumbar spine in a postmenopausal Han Chinese population
There was no statistically significant difference in CTR gene nucleotide sequence polymorphisms at 1377-bp between Chinese Xinjiang Han and Uygur patients with primary osteoporosis.
Data indicate a potential association between 3'UTR+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease.
Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias.
High calcitonin receptor is associated with prostate cancer.
the polymorphic genotypes of BGLAP, ER1, Col1A1 and CALCR are not found to be associated with osteoporosis in a single form but found to be associated in combined forms.
CTR was expressed by glioma cells in a majority of GBM tumours tested.
Allele C in CALCR gene was associated with reduced bone mass in cystic fibrosis children.
highly expressed on normal T- and B-lymphocytes
Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands.
relationship between calcitonin receptor (CTR) genotype and buccal marginal bone loss observed at stage II surgery for endosseous implants
an important role for filamin in the endocytic sorting and recycling of the internalized CTR
Co-expression of calcitonin receptors (CT) lacking a portion of domain 1 with receptor activity-modifying protein (RAMP) 1, 2, or 3 appears to produce functional CT-(8-32)-sensitive adrenomedullin receptors.
ALUI calcitonin receptor polymorphism genotype showed a positive association with prevalence of osteoporosis in the subjects
the expression of CTR is associated with the early cellular events involved in atherosclerotic plaque formation and is down-regulated as stabilisation of plaque progresses in the process of healing.
Endosomal signaling of the CLR mediates pain transmission.
calcitonin receptor is expressed in the suprachiasmatic nucleus and mediates body temperature fluctuations during the active phase in mice.
Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC niche.
data suggest that Clr-b modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies.
upregulated in synovial tissue of osteoarthritic mice by macrophage-derived IL-1 beta
protects the maternal skeleton during lactation by a direct action on osteocytes to inhibit osteolysis
Together, these data indicate that signaling through RAMP1 and CLR plays a role in mediating asthma pathology
The relevance of the OPG/RANK/RANKL system in the particle-induced osteolysis process, was investigated.
Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner
Odz4 is expressed in quiescent satellite cells, like calcitonin receptor, but the timing of the reappearance of these genes is different during regeneration.
The perinatal expression of CTR within the ENS suggests that the calcitonin/CTR system may have a role in the maturation of enteric neurons
CGRP-receptor component protein has been found to interact only with calcitonin-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide signaling.
CTR protects against hypercalcemia predominantly via its inhibitory action on osteoclasts.
Data show that amylin inactivation leads to a low bone mass due to an increase in bone resorption, whereas bone formation is unaffected.
Calcr is imprinted in a tissue-specific manner, with a predominant expression from the maternal allele in the brain
AUF1 p40, HuR, and the 3'UTR of the CTR mRNA transcript could be involved in posttranscriptional regulation of CTR mRNA expression.
Data show that mutation of calcitonin-like receptor did not affect its expression at the cell surface, but impaired the calcitonin gene-related peptide and adrenomedullin receptor function in the presence of receptor-activity-modifying proteins 1 and 2.
CTR is not only down regulated by signaling through the CTR but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins
These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress.
Intracoronary intermedin 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin receptors and beta-adrenoreceptor-mediated nitric oxide release.
expressed in preimplantation embryos
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.
, calcitonin receptor-like