Calcitonin Receptor antibody (AA 31-120)

Catalog No. ABIN725330

Product Details anti-Calcitonin Receptor Antibody

Target: Calcitonin Receptor (CALCR)

Binding Specificity: AA 31-120

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calcitonin Receptor antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat Calcitonin receptor

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Calcitonin Receptor antibody (ABIN725330)

Tsukamoto, Menuki, Murai, Hatakeyama, Takada, Furukawa, Sakai: "Elcatonin prevents bone loss caused by skeletal unloading by inhibiting preosteoclast fusion through the unloading-induced high expression of calcitonin receptors in bone marrow cells." in: Bone, Vol. 85, pp. 70-80, (2016) (PubMed).

Su, Gu, Dong, Mei: "Ibuprofen rescues abnormalities in periodontal tissues in conditional presenilin 1 and presenilin 2 double knockout mice." in: International journal of molecular sciences, Vol. 14, Issue 9, pp. 18457-69, (2013) (PubMed).

Han, Ji, Wang, Yan, Wang, Luo, Mei, Su: "Abnormalities in periodontal and salivary tissues in conditional presenilin 1 and presenilin 2 double knockout mice." in: Molecular and cellular biochemistry, Vol. 347, Issue 1-2, pp. 13-20, (2011) (PubMed).

Target Details for Calcitonin Receptor

Target: Calcitonin Receptor (CALCR)

Alternative Name: Calcitonin receptor (CALCR Products)

Synonyms: CALCR antibody, si:ch211-77k19.2 antibody, calcr antibody, CRT antibody, CT-R antibody, CTR antibody, CTR1 antibody, Clr antibody, Ct-R antibody, calcitonin receptor antibody, CALCR antibody, calcr antibody, Calcr antibody

Background:

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Subcellular location: Cell membrane

Synonyms: Calcitonin receptor, CT-R, C1A/C1B, Calcr

Gene ID: 116506

UniProt: P32214

Pathways: cAMP Metabolic Process