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anti-Human NUMA1 Antibodies:
anti-Mouse (Murine) NUMA1 Antibodies:
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Human Polyclonal NUMA1 Primary Antibody for ICC, IF - ABIN152988
Gaglio, Saredi, Compton: NuMA is required for the organization of microtubules into aster-like mitotic arrays. in The Journal of cell biology 1995
Show all 12 Pubmed References
Chicken Monoclonal NUMA1 Primary Antibody for IF, IP - ABIN968039
Elbi, Misteli, Hager: Recruitment of dioxin receptor to active transcription sites. in Molecular biology of the cell 2002
Show all 4 Pubmed References
Chicken Monoclonal NUMA1 Primary Antibody for IF, IP - ABIN968038
Munnia, Schütz, Romeike, Maldener, Glass, Maas, Nastainczyk, Feiden, Fischer, Meese: Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. in Oncogene 2001
Show all 4 Pubmed References
Human Monoclonal NUMA1 Primary Antibody for IHC (fro), IHC (p) - ABIN966706
Compton, Szilak, Cleveland: Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. in The Journal of cell biology 1992
Show all 3 Pubmed References
Cow (Bovine) Polyclonal NUMA1 Primary Antibody for WB - ABIN2784222
Kilpivaara, Rantanen, Tamminen, Aittomäki, Blomqvist, Nevanlinna: Comprehensive analysis of NuMA variation in breast cancer. in BMC cancer 2008
Human Polyclonal NUMA1 Primary Antibody for ICC, IF - ABIN261713
Yan, Li, Wang, Hong, Zhang, Yang, Lin, Zhang, He, Zheng, Tang, Yin, Shao: The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells. in The Journal of cell biology 2015
The function of nuclear mitotic apparatus protein (NuMA) in rDNA transcription and p53 (show TP53 Antibodies)-independent nucleolar stress response suggests a central role for NuMA in cellular homeostasis.
Importin-alpha/-beta regulates the NuMA functioning required for assembly of higher-order microtubule structures including the mitotic spindle.
Low post translational modifications of NuMA protein is associated with neoplasms.
Seven NuMA isoforms generated by alternative splicing were categorized into 3 groups: long, middle and short. Both exons 15 and 16 in long NuMA were "hotspot" for alternative splicing. Lower expression of short NuMA was observed in cancer cells compared with nonneoplastic controls.
Chimeric proteins constructed by fusion of LANA of Kaposi's sarcoma-associated herpesvirus with the NuMA could bind with ori-P and enhance replication of an ori-P-containing plasmid.
findings reveal a direct physical link between two important regulators of mitotic progression and demonstrate the critical role of the NuMA-Astrin (show SPAG5 Antibodies) interaction for accurate cell division.
Aurora-A (show AURKA Antibodies) governs the dynamic exchange between the cytoplasmic and the spindle pole-localized pools of NuMA. Aurora-A (show AURKA Antibodies) phosphorylates directly the C terminus of NuMA on three Ser (show SIGLEC1 Antibodies) residues, of which Ser1969 determines the dynamic behavior and the spindle orientation functions of NuMA.
Suppressor APC domain containing 2 negatively regulates the localization of LGN (show GPSM2 Antibodies) at the cell cortex, likely by competing with NuMA for its binding
NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.During anaphase correct NuMA localization is mediated by direct membrane phospholipid binding.
Retinoblastoma protein (pRB (show RB1 Antibodies)) have a novel function in regulating the mitotic function of NuMA and spindle organization, which are required for proper cell cycle progression.
These results reveal an additional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative use of spindle orientation in the skin to build diverse structures.
Loss of 4.1/NuMA interaction results in spindle orientation defects and inhibition of Cdk1 (show CDK1 Antibodies) causes increase in cortical NuMA localization
ectopic expression of BRAP2 (show BRAP Antibodies) inhibits nuclear localization of HMG20A (show HMG20A Antibodies) and NuMA1, and prevents nuclear envelope accumulation of SYNE2 (show SYNE2 Antibodies).
Fusion protein NuMA-RARalpha (show RARA Antibodies) cooperates with RXRalpha (show RXRA Antibodies) in the development of leukemia in hCG (show CGA Antibodies)-NuMA-RARalpha (show RARA Antibodies) transgenic mice.
Thus, NuMA is a defining feature of the mammalian spindle pole and functions as an essential tether linking bulk microtubules of the spindle to centrosomes.
Inhibiting Crm1 (show XPO1 Antibodies) in early metaphase causes the formation of excess acentriolar spindle poles containing NuMA and B23 (show NPM1 Antibodies), but does not affect centrosome numbers.
The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 (show JUN Antibodies) DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
MCAK (show KIF2C Antibodies) colocalized with NuMA and XMAP215 (show CKAP5 Antibodies) at the center of Ran asters where its activity is regulated by Aurora A (show AURKA Antibodies)-dependent phosphorylation of S196, which contributes to proper pole focusing
Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.
, centrophilin stabilizes mitotic spindle in mitotic cells
, structural nuclear protein
, nuclear mitotic apparatus protein 1
, nuclear mitotic apparatus protein 1-like
, nuclear mitotic apparatus protein 1 S homeolog
, nuclear/mitotic apparatus protein