Browse our PVRL4 Proteins (PVRL4)

Full name:: Poliovirus Receptor-Related 4 Proteins (PVRL4)

On www.antibodies-online.com are 15 Poliovirus Receptor-Related 4 (PVRL4) Proteins from 7 different suppliers available. Additionally we are shipping PVRL4 Antibodies (78) and PVRL4 Kits (7) and many more products for this protein. A total of 103 PVRL4 products are currently listed.

Synonyms:: 1200017F15Rik, EDSS1, LNIR, nectin-4, PRR4, PVRL4, RGD1559826, si:ch211-155e24.1

list all proteins	Gene Name	GeneID	UniProt
	PVRL4	71740	Q8R007
Rat PVRL4	PVRL4	498281
	PVRL4	81607	Q96NY8
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PVRL4 Proteins (PVRL4) by Origin

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Relevant Pathways for PVRL4 Proteins

Cell-Cell Junction Organization

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More Proteins for PVRL4 Interaction Partners

Mouse (Murine) Poliovirus Receptor-Related 4 (PVRL4) interaction partners

nectin-4 serves as a stimulatory co-receptor for the prolactin receptor (show PRLR Proteins) by regulating the feedback inhibition of SOCS1 (show SOCS1 Proteins) in the JAK2 (show JAK2 Proteins)-STAT5a (show STAT5A Proteins) signaling pathway
Novel type of cell adhesion apparatus is mediated by Nectin-1 (show PVRL1 Proteins) and Nectin-4. It's implicated in prolactin receptor (show PRLR Proteins) signaling for mammary gland development.
Pvrl1 (show PVRL1 Proteins) is a bona fide target gene of the transcription factor p63 (show CKAP4 Proteins), whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6 (show IRF6 Proteins)
Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.
Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin (show PVRL1 Proteins) adhesion molecule (show NCAM1 Proteins).

Human Poliovirus Receptor-Related 4 (PVRL4) interaction partners

We suggest that Nectin-4 is a relevant prognostic factor and a therapeutic target in luminalB (HER2 (show ERBB2 Proteins) negative) breast cancer.
Nectin-4 promotes cell-cell adhesion/aggregation, migration, and proliferation of ovarian tumor cells.
Nectin-4 is not only a BCSC marker but also a breast cancer metastasis marker
This study suggests that PVRL4 is post-transcriptionally regulated by miR (show MLXIP Proteins)-128 and miR (show MLXIP Proteins)-31.
High Nectin-4 expression is associated with neoplasms.
We show that Measles virus gains entry into MCF7, DLD (show DLD Proteins)-1, and HTB-20 cancer cells through a PVRL4-mediated macropinocytosis pathway and identified the typical cellular GTPase (show RACGAP1 Proteins) and kinase involved.
nectin-4 serves as a stimulatory co-receptor for the prolactin receptor (show PRLR Proteins) by regulating the feedback inhibition of SOCS1 (show SOCS1 Proteins) in the JAK2 (show JAK2 Proteins)-STAT5a (show STAT5A Proteins) signaling pathway
Nectin-4 is both a new promising prognostic biomarker and specific therapeutic target for Triple-negative breast cancers
ADAM17 (show ADAM17 Proteins) and ADAM10 (show ADAM10 Proteins) cleave Nectin-4 and release soluble Nectin-4 (sN4).
The data presented in this study suggested that nectin-4 may be a therapeutic target for systemic lupus erythematous through affecting the cell apoptosis

PVRL4 Protein Profile

Protein Summary

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Alternative names and synonyms associated with PVRL4

nectin cell adhesion molecule 4 (NECTIN4)
nectin cell adhesion molecule 4 (nectin4)
nectin cell adhesion molecule 4 (Nectin4)

1200017F15Rik protein
EDSS1 protein
LNIR protein
nectin-4 protein
PRR4 protein
PVRL4 protein
RGD1559826 protein
si:ch211-155e24.1 protein

Protein level used designations for PVRL4

poliovirus receptor-related 4 , poliovirus receptor-related protein 4-like , ig superfamily receptor LNIR , nectin 4 , nectin-4 , poliovirus receptor-related protein 4 , Ig superfamily receptor LNIR

GENE ID	SPECIES
609931	Canis lupus familiaris
794920	Danio rerio
100032730	Monodelphis domestica
100066309	Equus caballus
100348580	Oryctolagus cuniculus
100435072	Pongo abelii
71740	Mus musculus
498281	Rattus norvegicus
81607	Homo sapiens
507718	Bos taurus

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