Protein Summary

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Alternative names and synonyms associated with PVRL4

• nectin cell adhesion molecule 4 (NECTIN4) antibody
• nectin cell adhesion molecule 4 (nectin4) antibody
• nectin cell adhesion molecule 4 (Nectin4) antibody

• 1200017F15Rik antibody
• EDSS1 antibody
• LNIR antibody
• nectin-4 antibody
• PRR4 antibody
• Show all synonym aliases
• PVRL4 antibody
• RGD1559826 antibody
• si:ch211-155e24.1 antibody

Protein level used designations for PVRL4

poliovirus receptor-related 4 , poliovirus receptor-related protein 4-like , ig superfamily receptor LNIR , nectin 4 , nectin-4 , poliovirus receptor-related protein 4 , Ig superfamily receptor LNIR