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nectin-4 serves as a stimulatory co-receptor for the prolactin receptor (show PRLR Proteins) by regulating the feedback inhibition of SOCS1 (show SOCS1 Proteins) in the JAK2 (show JAK2 Proteins)-STAT5a (show STAT5A Proteins) signaling pathway
Novel type of cell adhesion apparatus is mediated by Nectin-1 (show PVRL1 Proteins) and Nectin-4. It's implicated in prolactin receptor (show PRLR Proteins) signaling for mammary gland development.
Pvrl1 (show PVRL1 Proteins) is a bona fide target gene of the transcription factor p63 (show CKAP4 Proteins), whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6 (show IRF6 Proteins)
Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.
Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin (show PVRL1 Proteins) adhesion molecule (show NCAM1 Proteins).
Nectin-4 promotes cell-cell adhesion/aggregation, migration, and proliferation of ovarian tumor cells.
Nectin-4 is not only a BCSC marker but also a breast cancer metastasis marker
This study suggests that PVRL4 is post-transcriptionally regulated by miR (show MLXIP Proteins)-128 and miR (show MLXIP Proteins)-31.
High Nectin-4 expression is associated with neoplasms.
We show that Measles virus gains entry into MCF7, DLD (show DLD Proteins)-1, and HTB-20 cancer cells through a PVRL4-mediated macropinocytosis pathway and identified the typical cellular GTPase (show RACGAP1 Proteins) and kinase involved.
Nectin-4 is both a new promising prognostic biomarker and specific therapeutic target for Triple-negative breast cancers
ADAM17 (show ADAM17 Proteins) and ADAM10 (show ADAM10 Proteins) cleave Nectin-4 and release soluble Nectin-4 (sN4).
The data presented in this study suggested that nectin-4 may be a therapeutic target for systemic lupus erythematous through affecting the cell apoptosis
Nectin-4 is critical for gallbladder cancer cell progression via PI3K/AKT pathway activation of Rac1.
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
poliovirus receptor-related 4
, poliovirus receptor-related protein 4-like
, ig superfamily receptor LNIR
, nectin 4
, poliovirus receptor-related protein 4
, Ig superfamily receptor LNIR