Browse our anti-Aurora A (AURKA) Antibodies

Full name:: anti-Aurora Kinase A Antibodies (AURKA)

On www.antibodies-online.com are 296 Aurora Kinase A (AURKA) Antibodies from 0 different suppliers available. A total of 346 Aurora A products are currently listed.

Synonyms:: 87A7-9/2, AIK, AIRK1, ARK-1, Ark1, AU019385, aur-a, AURA, aurka, aurka-a, Aurora-A, AURORA2, AW539821, Ayk1, BTAK, CG3068, ck10, ck[10], Dmel\\CG3068, Eg2, IAK, IAK1, l(3)87Ac, l(3)ck10, pEg2, PPP1R47, Stk6, STK7, STK15, wu:fb37c10, wu:fc02c02, zgc:100912

list all antibodies	Gene Name	GeneID	UniProt
Anti-Human AURKA	AURKA	6790	O14965
Anti-Mouse AURKA	AURKA	20878	P97477
Anti-Rat AURKA	AURKA	261730
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Relevant Pathways for anti-Aurora A Antibodies

More product categories related to Aurora A Antibody

Top referenced anti-Aurora A Antibodies

Human Polyclonal Aurora A Primary Antibody for ICC, IF - ABIN151704 : Saskova, Solc, Baran, Kubelka, Schultz, Motlik: Aurora kinase A controls meiosis I progression in mouse oocytes. in Cell cycle (Georgetown, Tex.) 2008 (PubMed)
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Human Polyclonal Aurora A Primary Antibody for FACS, IF - ABIN1882163 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
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Human Polyclonal Aurora A Primary Antibody for ICC, IF - ABIN151735 : Hontz, Li, Lingle, Negron, Bruzek, Salisbury, Li: Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. in Cancer research 2007 (PubMed)
Show all 5 Pubmed References
Human Polyclonal Aurora A Primary Antibody for ICC, IF - ABIN4282417 : Honma, Nakanishi, Nakanoko, Ando, Saeki, Oki, Iimori, Kitao, Kakeji, Maehara: Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers. in Surgery today 2014 (PubMed)
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Human Monoclonal Aurora A Primary Antibody for IF, IP - ABIN2477554 : Quinn, Crane, Kocal, Best, Cameron, Rushmore, Farber, Hayes: Protective activity of different hepatic cytosolic glutathione S-transferases against DNA-binding metabolites of aflatoxin B1. in Toxicology and applied pharmacology 1990 (PubMed)
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Human Monoclonal Aurora A Primary Antibody for IF, WB - ABIN2477555 : Cremet, Descamps, Vérite, Martin, Prigent: Preparation and characterization of a human aurora-A kinase monoclonal antibody. in Molecular and cellular biochemistry 2003 (PubMed)
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Human Monoclonal Aurora A Primary Antibody for IHC, ELISA - ABIN968972 : Veerakumarasivam, Goldstein, Saeb-Parsy, Scott, Warren, Thorne, Mills, Venkitaraman, Neal, Kelly: AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma. in Cell cycle (Georgetown, Tex.) 2008 (PubMed)
Show all 2 Pubmed References
Human Monoclonal Aurora A Primary Antibody for ICC, FACS - ABIN968971 : De Luca, Brunetto, Asteriti, Giubettini, Lavia, Guarguaglini: Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity. in Oncogene 2008 (PubMed)
Show all 2 Pubmed References
Cow (Bovine) Monoclonal Aurora A Primary Antibody for ICC, IF - ABIN151177 : Mahdipour, Leitoguinho, Zacarias Silva, van Tol, Stout, Rodrigues, Roelen: TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes. in PLoS ONE 2015 (PubMed)
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Human Monoclonal Aurora A Primary Antibody for IF, IHC (p) - ABIN563053 : Lo Iacono, Monica, Saviozzi, Ceppi, Bracco, Papotti, Scagliotti: Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation. in Journal of translational medicine 2011 (PubMed)
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More Antibodies against Aurora A Interaction Partners

Fruit Fly (Drosophila melanogaster) Aurora Kinase A (AURKA) interaction partners

WDR62 (show WDR62 Antibodies) controls brain growth through lineage-specific interactions with master mitotic signaling kinase, aurora A kinase.
Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.
Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.
AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.
Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Drosophila melanogaster aurora A phosphorylates the dynactin (show DCTN1 Antibodies) subunit p150(glued (show DCTN1 Antibodies)) on sites required for its association with the mitotic spindle.
One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 (show CKAP5 Antibodies) microtubule-associated protein (show FAM82A2 Antibodies) may be recruited, and thus modulate the behavior of astral microtubules.
Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.
Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein.
Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin (show TUBG1 Antibodies) to the centrosome and to organize microtubule-nucleating sites via interaction with CNN.

Zebrafish Aurora Kinase A (AURKA) interaction partners

Zebrafish Aurora-A is critically required for embryonic proliferation during development.

Human Aurora Kinase A (AURKA) interaction partners

lncRNA TUG1 associates with advanced disease and worse prognosis in adult AML (show RUNX1 Antibodies) patients, and it induces AML (show RUNX1 Antibodies) cell proliferation and represses cell apoptosis via targeting AURKA
Aurora A is able to individually shorten cilia when cilia are growing but requires interaction with never in mitosis-kinase 2 (Nek2 (show NEK2 Antibodies)) when cilia are being absorbed. Inhibition of Aurora A increases cilia number.
In patients who received alisertib for advanced or metastatic urothelial carcinoma, longer progression-free survival was observed in carriers of the minor allele A of rs2273535 in AURKA than in patients who were homozygous for the major allele T.
The combination also reduces the growth of PDAC xenografts in vivo Mechanistically, it was found that inhibiting methyltransferases of the H3K9 pathway in cells, which are arrested in G2-M after targeting AURKA, decreases H3K9 methylation at centromeres, induces mitotic aberrations, triggers an aberrant mitotic check point response, and ultimately leads to mitotic catastrophe
Prostate cancer cells expressing an S273A mutant of CHIP have attenuated AR degradation upon 2-ME treatment compared with cells expressing wild-type CHIP, supporting the idea that CHIP phosphorylation by Aurora A activates its E3 ligase activity for the AR
Our results indicate that AURKA plays an important role in the activation of EIF4E (show EIF4E Antibodies) and cap-dependent translation. Targeting the AURKA-EIF4E (show EIF4E Antibodies)-c-MYC (show MYC Antibodies) axis using alisertib is a novel therapeutic strategy that can be applicable for everolimus-resistant tumors and/or subgroups of cancers that show overexpression of AURKA and activation of EIF4E (show EIF4E Antibodies) and c-MYC (show MYC Antibodies)
Aurora-A may serve as a predictive biomarker of radiation response and a therapeutic target to reverse radiation therapy resistance.
We also propose a model for the stabilization mechanism in which binding to Aurora-A alters how N-Myc (show MYCN Antibodies) interacts with SCF (show KITLG Antibodies)(FbxW7 (show FBXW7 Antibodies)) to disfavor the generation of Lys48-linked polyubiquitin (show UBB Antibodies) chains
Results identified AURKA to be significantly upregulated in the lung squamous cell carcinoma tissues of smoking patients and may play an important role in diagnosis and prognosis.
Authors conclude that AURKA may revive dormant tumor cells via FAK (show PTK2 Antibodies)/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway activation, thereby promoting migration and invasion in laryngeal cancer.

Mouse (Murine) Aurora Kinase A (AURKA) interaction partners

Aurora A and Plk4 (show PLK4 Antibodies) are rate-limiting factors contributing to microtubule growth as the acentriolar oocyte resumes meiosis.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB (show AURKB Antibodies) or AURKC (show AURKC Antibodies) using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA expression is crucial for spindle formation in meiosis
Aurora kinase inhibitor CCT137690 induces necrosis-like death in pancreatic ductal adenocarcinoma cells, via RIPK1, RIPK3, and MLKL signaling.
CIP2A (show KIAA1524 Antibodies) acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 (show PLK1 Antibodies) and aurora A during meiotic maturation in mouse oocytes
AURKA stabilizes MYC (show MYC Antibodies) to promote tp53 (show TP53 Antibodies)-altered liver tumor cell survival.
Bcl2l10 (show BCL2L10 Antibodies), Tpx2 (show DAZL Antibodies), and Aurka co-localized on the meiotic spindles, and Bcl2l10 (show BCL2L10 Antibodies) was present in the same complex with Tpx2 (show DAZL Antibodies).
Suppression of neuroendocrine and NEPC development by ICT was associated with dose-dependent inhibitory effects on abnormally elevated IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) and Aurora kinase A in vitro and in vivo
Our findings demonstrate that prolonged overexpression of Aurora-A can be a driver somatic genetic event in mammary adenocarcinomas associated with deregulated tumor-relevant pathways in the Aurora-A subset of human breast cancer
Data show that aurora-A kinase (AURKA) supports effective spindle formation in zygote.
observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.

Cow (Bovine) Aurora Kinase A (AURKA) interaction partners

Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.

Pig (Porcine) Aurora Kinase A (AURKA) interaction partners

Aurora kinase A is unlikely to be involved in CPEB1 (show CPEB1 Antibodies) activating phosphorylation and cyclin B1 (show CCNB1 Antibodies) mRNA polyadenylation during meiotic maturation of porcine oocytes.
Aurora-A may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during porcine oocyte meiotic maturation, fertilization and early embryonic mitosis
Aurora A stimulates the protein synthesis and promotes the meiotic resumption.

Xenopus laevis Aurora Kinase A (AURKA) interaction partners

These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.
MCAK (show KIF2C Antibodies) colocalized with NuMA (show NUMA1 Antibodies) and XMAP215 (show CKAP5 Antibodies) at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing
Plx1 (show PLK1 Antibodies) promotes activation of Aurora A, most likely through TPX2.
Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.
Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.
binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A
Results suggest that phosphorylation of maskin (show TACC3 Antibodies) by Aurora-A prevents meiosis II proteins from being produced during meiosis I.
The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.
Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2
The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.

Aurora A (AURKA) Antigen Profile

Antigen Summary

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Aurora A (AURKA)

aurora A (aurA) antibody
aurora kinase A (aurka) antibody
hypothetical protein (Aurora-A) antibody
aurora kinase A (AURKA) antibody
aurora kinase A (Aurka) antibody
aurora kinase A L homeolog (aurka.L) antibody

87A7-9/2 antibody
AIK antibody
AIRK1 antibody
ARK-1 antibody
Ark1 antibody
AU019385 antibody
aur-a antibody
AURA antibody
aurka antibody
aurka-a antibody
Aurora-A antibody
AURORA2 antibody
AW539821 antibody
Ayk1 antibody
BTAK antibody
CG3068 antibody
ck10 antibody
ck[10] antibody
Dmel\\CG3068 antibody
Eg2 antibody
IAK antibody
IAK1 antibody
l(3)87Ac antibody
l(3)ck10 antibody
pEg2 antibody
PPP1R47 antibody
Stk6 antibody
STK7 antibody
STK15 antibody
wu:fb37c10 antibody
wu:fc02c02 antibody
zgc:100912 antibody

Protein level used designations for anti-Aurora Kinase A (AURKA) Antibodies

, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , A-type aurora kinase AuroraA CG3068-PA aur-PA aurora A aurora A kinase aurora kinase aurora-A early-A fruhe2 Aurora A hypothetical protein aurora kinase A fb37c10 fc02c02 serine/threonine-protein kinase 6 serine/threonine protein kinase 6 aurora A kinase protein serine/threonine-protein kinase 6-like ARK-1 Aurora-A kinase IPL1-related kinase aurora 2 aurora-related kinase 1 aurora/IPL1-like kinase aurora/IPL1-related kinase 1 breast tumor-amplified kinase breast-tumor-amplified kinase hARK1 protein phosphatase 1, regulatory subunit 47 serine/threonine kinase 6 serine/threonine protein kinase 15 serine/threonine-protein kinase 15 serine/threonine-protein kinase aurora-A aurora family kinase 1 ipl1- and aurora-related kinase 1 serine/threonine-protein kinase Ayk1 ratAurA Aurora-A Serine/threonine-protein kinase 6 aurora kinase A-A p46Eg265 pEg2 serine/threonine-protein kinase 6-A serine/threonine-protein kinase Eg2 serine/threonine-protein kinase Eg2-A

GENE ID	SPECIES
41446	Drosophila melanogaster
549324	Xenopus (Silurana) tropicalis
7200473	Phaeodactylum tricornutum CCAP 1055/1
428167	Gallus gallus
445246	Danio rerio
469980	Pan troglodytes
698190	Macaca mulatta
100216431	Ovis aries
100303586	Saccoglossus kowalevskii
100398107	Callithrix jacchus
100459866	Pongo abelii
100469600	Ailuropoda melanoleuca
6790	Homo sapiens
20878	Mus musculus
261730	Rattus norvegicus
504437	Bos taurus
485940	Canis lupus familiaris
574063	Sus scrofa
397925	Xenopus laevis

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Show all anti-Aurora Kinase A (AURKA) Antibodies with Pubmed References