Browse our anti-CDKN1B (CDKN1B) Antibodies

Human Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

1. FLT3 (show FLT3 Antibodies) and FLT3 (show FLT3 Antibodies)-ITD can directly bind and selectively phosphorylate p27kip1 on tyrosine residue 88 in acute myeloid leukemia (show BCL11A Antibodies). Inhibition of FLT3 (show FLT3 Antibodies)-ITD in cell lines strongly reduced p27 (show PAK2 Antibodies) tyrosine 88 phosphorylation and resulted in increased p27 (show PAK2 Antibodies) levels and cell cycle arrest

2. Our results suggest that oxidised photoreceptor outer segments -induced retinal pigment epithelial cell cytokinesis failure is, at least in part, due to the upregulation of p27kip1 through activating the PKC (show PRRT2 Antibodies), particularly PKCzeta (show PRKCZ Antibodies) pathway

3. p27Kip1-838C>A; rs36228499 is functional in human venous smooth muscle cells (SMCs) and in adventitial cells. The AA genotype is associated with stronger expression of the p27 (show PAK2 Antibodies) gene and p27 (show PAK2 Antibodies) protein. Only the adventitial cells, and not the SMCs, are responsive to the inhibitory effects of the protective AA genotype in cell growth.

4. Overview of CDKN1B mutations in MEN4 (review)

5. Expression of CIP/KIP (show CIB1 Antibodies) proteins was found abundantly within the proliferative hair matrix, concomitant with a role in cell cycle checkpoint control. p21(CIP1 (show CDKN1A Antibodies)), p27(KIP1) and cyclin E (show CCNE1 Antibodies) persisted within post-mitotic keratinocytes of the pre-cortex, whereas p57(KIP2 (show CDKN1C Antibodies)) protein decreased but became nuclear.

6. Taken together, these data clearly show that FKBP3 (show FKBP3 Antibodies)/Sp1 (show PSG1 Antibodies)/HDAC2 (show HDAC2 Antibodies)/p27 (show PAK2 Antibodies) control cell proliferation during non-small cell lung cancer development.

7. Sumoylation of K73 (show KRT73 Antibodies) site of cyclin-dependent kinase inhibitor 1B (p27kip1) is critical to the nuclear-cytoplasmic translocation of p27kip1, which is mediated by RAN binding protein 2 (show RANBP2 Antibodies) and CRM1 (show XPO1 Antibodies) protein. Sumoylation of p27kip1 promotes the proliferation of cholangiocarcinoma QBC939 cells

8. loss of CDKN1B increased the prevalence of cell cycle regulator defects in immature T-ALL, usually only ascribed to CDKN2A/B deletions, and that CDKN1B deletions frequently coincide with expression of MEF2C (show MEF2C Antibodies), considered as one of the driving oncogenes in immature early T-cell precursor (ETP) ALL

9. This study reveals a molecular pathway involving lncRNA GAS5/E2F1 (show E2F1 Antibodies)/P27(Kip1) which regulates cell proliferation and could be a potential therapeutic target in prostate cancer.

10. miR (show MLXIP Antibodies)-155-5p promotes fibroblast cell proliferation and inhibits FOXO (show FOXO3 Antibodies) signaling pathway by negative modulation of both FOXO3 (show FOXO3 Antibodies) and CDKN1B in vulvar lichen sclerosis

Zebrafish Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

Cow (Bovine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

1. p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc

Pig (Porcine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

1. FoxO1a (show FOXO1 Antibodies) can regulate p27kip nuclear localization

2. the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

1. Findings demonstrate functional interplay between a transcriptional regulator and p27(kip1) to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA (show RHOA Antibodies) signaling.

2. Specifically, the proteins p18INK4C (show CDKN2C Antibodies), p21CIP1 (show CDKN1A Antibodies) and p27KIP1 seem to play an outstanding role in the maintenance of the differentiated state of adipocytes.

3. Data show that both bone marrow-derived and gastric epithelial cells contribute to the increased gastric cancer susceptibility of p27-deficient Helicobacter pylori (H. pylori) -infected mice.

4. Our results revealed that CKS1 (show CKS1B Antibodies) is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.

5. p27kip1 is involved in the decisive step around cell-cycle exit and plays an important role in activity-regulated and functionally relevant adult hippocampal neurogenesis.

6. p27(Kip1)-target genes are involved in cell adhesion and cell signaling in mouse embryonic fibroblasts.

7. This study demonstrates that LMP2A uses the role of MYC (show MYC Antibodies) in the cell cycle, particularly in the p27(kip1) degradation process, to accelerate lymphomagenesis in vivo.

8. Study reports that p27 normally exerts a negative feedback on p21 (show D4S234E Antibodies) expression: p27 directly represses the expression of the transcription factor Pitx2 (show PITX2 Antibodies) which in turn maintains decreased p21 (show D4S234E Antibodies) levels. Consequently, in cells lacking p27, de-repression of Pitx2 (show PITX2 Antibodies) causes the up-regulation of p21 (show D4S234E Antibodies) showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (show PITX2 Antibodies) and p21 (show D4S234E Antibodies).

9. Fbxo7 (show FBXO7 Antibodies)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (show CDK6 Antibodies) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (show FBXO7 Antibodies) at different stages in T-cell development.

10. systems-level control of cell cycle arrest by pRB (show PGR Antibodies)-E2F (show E2F1 Antibodies) and p27-CDK (show CDK4 Antibodies) regulation, is reported.