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CDKN1B antibody (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1)) pThr157 Primary Antibody

CDKN1B Reactivity: Human DB, IHC (p) Host: Rabbit Polyclonal RB28265 unconjugated
Pubmed (1 reference)
Catalog No. ABIN389616
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  • Target See all CDKN1B Antibodies
    CDKN1B
    Binding Specificity
    • 39
    • 28
    • 22
    • 20
    • 18
    • 16
    • 11
    • 11
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr157
    Reactivity
    • 315
    • 148
    • 129
    • 42
    • 10
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Host
    • 251
    • 65
    • 14
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 263
    • 71
    Polyclonal
    Conjugate
    • 139
    • 26
    • 23
    • 19
    • 18
    • 16
    • 16
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CDKN1B antibody is un-conjugated
    Application
    • 224
    • 163
    • 90
    • 76
    • 59
    • 48
    • 32
    • 30
    • 22
    • 16
    • 12
    • 8
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T157 of human p27Kip1.
    Clone
    RB28265
    Isotype
    Ig Fraction
  • Application Notes
    IHC-P: 1:50~100. DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Le, Mao, He, Claret, Xia, Ahmed, Hung, Siddik, Bast: "The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells." in: Journal of the National Cancer Institute, Vol. 103, Issue 18, pp. 1403-22, (2011) (PubMed).

  • Target
    CDKN1B
    Alternative Name
    p27Kip1 (CDKN1B Products)
    Synonyms
    CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cdkn1b, sb:cb611, wu:fb63g10, wu:fb64g10, wu:fe18e03, CDKN1B, Kip1, p27, FAM14D, ISG12, ISG12A, P27, Cdki1b, AA408329, AI843786, p27Kip1, cdkn1bl, cyclin dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor 1Bb, interferon alpha inducible protein 27, cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor 1Ba, CDKN1B, cdkn1bb, IFI27, Cdkn1b, cdkn1ba
    Background
    P27Kip1 is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
    Molecular Weight
    22073
    Gene ID
    NCBI Accession
    NP_004055
    UniProt
    P46527
    Pathways
    Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
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