Browse our anti-E2F4 (E2F4) Antibodies

Full name:: anti-E2F Transcription Factor 4, P107/p130-Binding Antibodies (E2F4)

On www.antibodies-online.com are 98 E2F Transcription Factor 4, P107/p130-Binding (E2F4) Antibodies from 18 different suppliers available. Additionally we are shipping E2F4 Proteins (4) and many more products for this protein. A total of 114 E2F4 products are currently listed.

Synonyms:: 2010111M04Rik, AI427446, e2f-4, E2F4, fb72f07, wu:fb72f07, wu:fe05f06, zgc:63815

list all antibodies	Gene Name	GeneID	UniProt
	E2F4	1874	Q16254
	E2F4	104394	Q8R0K9
	E2F4	100360427
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Relevant Pathways for anti-E2F4 Antibodies

Regulation of Cell Size

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Top referenced anti-E2F4 Antibodies

Human Polyclonal E2F4 Primary Antibody for ICC, IF - ABIN439334 : Morillo, Abanto, Román, Frade: Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation. in Molecular and cellular biology 2012 (PubMed)

More Antibodies against E2F4 Interaction Partners

Human E2F Transcription Factor 4, P107/p130-Binding (E2F4) interaction partners

Studied expression of E2F4 in breast cancer patients undergoing neoadjuvant chemotherapy; found target gene-based signature of E2F4 can be used to predict neoadjuvant response.
The authors found that phosphorylation of residues S650 and S975 in p107 (show RBL1 Antibodies) weakens the E2F4 transactivation domain binding.
E2F4 gene expression in glioblastoma.
Integrative genomic analyses confirm that E2F4 or E2F1 (show E2F1 Antibodies) expression level is high in liposarcoma patients which associate with unfavorable prognosis.
This study found evidence that the number of triplet AGC (show ACAN Antibodies) repeats in the E2F4 gene may play a role in the susceptibility to early-onset colorectal cancer.
PHF8 (show PHF8 Antibodies) reduces the H3K9me2 level at the E2F4 transcriptional start site, demonstrating a direct function of PHF8 (show PHF8 Antibodies) in endothelial E2F4 gene regulation
cell cycle-dependent transcription of the TRAIP (show TRAIP Antibodies) gene by E2F1 (show E2F1 Antibodies), E2F2 (show E2F2 Antibodies), and E2F4 and rapid protein degradation leads to cell cycle-dependent expression with a maximum in G2/M
Authors show that BRCA1 and RAD17 (show RAD17 Antibodies) genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-function mutant p53 (show TP53 Antibodies) proteins.
Data suggest that aberrant cell cycle activation in Ewing sarcoma is due to the de-repression of transcription factor E2F targets of transcriptional induction and physical recruitment of E2F3 by fusion protein EWS (show EWSR1 Antibodies)-FLI1 (show FLI1 Antibodies) replacing E2F4 on their promoters.
The inverse immunohistochemical relationship between E2F1 (show E2F1 Antibodies) and E2F4 indicates a possible mechanistic interlink in colorectal cancer.

Mouse (Murine) E2F Transcription Factor 4, P107/p130-Binding (E2F4) interaction partners

E2f4 and E2f5 display overlapping roles in controlling the normal development of the male reproductive system.
Following stress exposure, E2F4-p130 complexes are lost rapidly along with the presence of E2F4 at E2F (show E2F1 Antibodies)-containing B-Myb (show MYBL2 Antibodies) promoter sites.
E2F4 is part of a transcriptional repressor complex comprising p130 and HDAC1 (show HDAC1 Antibodies) in cardiac myocytes. Relief from E2F4-dependent gene silencing induces the expression of pro-apoptotic genes.
In terminally differentiated cells, common KDM5A (show KDM5A Antibodies) and E2F4 gene targets were bound by the pRB (show PGR Antibodies)-related protein p130, a DREAM complex component.
We report here a new cellular function of p27 (show CDKN1B Antibodies) as a transcriptional regulator in association with p130/E2F4 complexes that could be relevant for tumorigenesis.
Induction of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in mouse mesenchymal stem cells is associated with activation of the p130 and E2f4 and formation of the p130/Gsk3beta/beta-catenin (show CTNNB1 Antibodies) complex.
E2F4 plays an important role in enabling osteoblast progenitors to exit the cell cycle and subsequently differentiate thereby contributing to the commitment of these cells to the bone lineage.
Our data indicate that E2F4 is required for cardiomyocyte proliferation and suggest a function for E2F4 in mitosis
E2F4 controls cell cycle exit through different mechanisms.
interactions are regulated by G1 cyclin/cyclin (show PCNA Antibodies)-dependent kinase (show CDK1 Antibodies)-coordinated phosphorylation of endogenous pocket proteins

E2F4 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

Alternative names and synonyms associated with E2F4

E2F transcription factor 4 (E2F4) antibody
E2F transcription factor 4 (E2f4) antibody
E2F transcription factor 4 S homeolog (e2f4.S) antibody
E2F transcription factor 4 (e2f4) antibody

2010111M04Rik antibody
AI427446 antibody
e2f-4 antibody
E2F4 antibody
fb72f07 antibody
wu:fb72f07 antibody
wu:fe05f06 antibody
zgc:63815 antibody

Protein level used designations for E2F4

p107/p130-binding protein , transcription factor E2F4 , E2F-4 , E2F transcription factor 4, p107/p130-binding , E2F transcription factor 4

GENE ID	SPECIES
1874	Homo sapiens
104394	Mus musculus
446541	Xenopus laevis
454158	Pan troglodytes
525428	Bos taurus
611243	Canis lupus familiaris
696864	Macaca mulatta
769430	Gallus gallus
100038079	Xenopus (Silurana) tropicalis
100600930	Nomascus leucogenys
100360427	Rattus norvegicus
100522677	Sus scrofa
406741	Danio rerio
100735380	Cavia porcellus

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Show all anti-E2F Transcription Factor 4, P107/p130-Binding (E2F4) Antibodies with Pubmed References

Human E2F Transcription Factor 4, P107/p130-Binding (E2F4) interaction partners

Mouse (Murine) E2F Transcription Factor 4, P107/p130-Binding (E2F4) interaction partners

Antigen Summary

Alternative names and synonyms associated with E2F4

Protein level used designations for E2F4