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Human Monoclonal INCENP Primary Antibody for ICC, FACS - ABIN969529
Xu, Ogawa, Vagnarelli, Bergmann, Hudson, Ruchaud, Fukagawa, Earnshaw, Samejima: INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. in The Journal of cell biology 2009
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Human Monoclonal INCENP Primary Antibody for ICC, IF - ABIN2668314
Wang, Ballister, Lampson: Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient. in The Journal of cell biology 2011
Genotype of INCENP affect promoter activity and bovine semen quality.
INCENP labels the spermatogonia synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocentres
INCENP recruits Aurora-C (or some other factor(s) recruit INCENP and Aurora-C) to meiotic chromosomes, while Aurora-C may either work alone or cooperate with Aurora-B to regulate chromosome segregation during male meiosis
Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin and Inner Centromere Protein (INCENP) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported.
Data unveils a novel mechanism of PRMT1-mediated CPC regulation through methylation of INCENP.
The data suggest that INCENP in the chromosomal passenger complex pathway contributes to estrogen receptor-negative breast cancer susceptibility in the European population.
Our results provide the structural basis and energetics of the human Aurora-A(G198N) - INCENP complex
v-Src induces the failure of cytokinesis and the delocalization of Mklp1, Aurora B, and INCENP from the spindle midzone.
HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet unknown interphase functions of the chromosome passenger complex (CPC) or Sgo1 at the centromeres.
Results indicate that INCENP-Aurora B localized at centromeres/inner kinetochores is sufficient to mediate SAC activity upon spindle disruption.
Dephosphorylation of INCENP at anaphase and the concomitant relocation of the chromosomal passenger protein complex prevents kinetochore recruitment of mitotic checkpoint proteins.
Data show that binding to INCENP is alone critical to the distinct function of Aurora B, and although G198 of Aurora A is required for TPX2 binding, N142G Aurora B retains INCENP binding and Aurora B function.
Aurora B kinase activity is stimulated by INCENP and C-terminal region of INCENP is sufficient for activation
association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C
Recruitment of MKLP1 to the midzone/midbody by INCENP is a crucial step for the midbody formation and completion of cytokinesis in mammalian cells.
Aurora-C is a chromosomal passenger protein that disrupts the association of INCENP with Aurora-B and may serve as a key regulator in cell division
Data show that INCENP has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin to INCENP.
INCENP phosphorylation by Cdk1 is necessary for the recruitment of Plk1 to the kinetochore.
A functional module within the chromosomal passenger complex involving the inner centromere protein INCENP, Survivin, and Borealin.
protein truncation and in vitro mutagenesis,have identified the nucleolar localization sequences on INCENP
Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle.
High INCENP expression is associated with high grade non-Hodgkin B-cell lymphomas.
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A\; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994
inner centromere protein antigens 135/155kDa
, inner centromere protein B
, inner centromere protein
, similar to XL-INCENP
, inner centromere protein-like
, class I INCENP protein
, class II INCENP protein
, binds and activates aurora-B and -C in vivo and in vitro
, chromosomal passenger protein
, inner centromere protein INCENP