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anti-Rat (Rattus) INCENP Antibodies:
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Human Monoclonal INCENP Primary Antibody for ICC, FACS - ABIN969529
Xu, Ogawa, Vagnarelli, Bergmann, Hudson, Ruchaud, Fukagawa, Earnshaw, Samejima: INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. in The Journal of cell biology 2009
Show all 4 Pubmed References
Human Monoclonal INCENP Primary Antibody for ICC, IF - ABIN2668314
Wang, Ballister, Lampson: Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient. in The Journal of cell biology 2011
Genotype of INCENP affect promoter activity and bovine semen quality.
INCENP labels the spermatogonia synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocentres
INCENP recruits Aurora-C (show AURKC Antibodies) (or some other factor(s) recruit INCENP and Aurora-C (show AURKC Antibodies)) to meiotic chromosomes, while Aurora-C (show AURKC Antibodies) may either work alone or cooperate with Aurora-B (show AURKC Antibodies) to regulate chromosome segregation during male meiosis
Aurora-C (show AURKC Antibodies) interactions with members of the Chromosome Passenger Complex (CPC), Survivin (show BIRC5 Antibodies) and Inner Centromere Protein (INCENP) in reference to known Aurora-B (show AURKB Antibodies) interactions to understand the functional significance of Aurora-C (show AURKC Antibodies) overexpression in human cancer cells, is reported.
Data unveils a novel mechanism of PRMT1 (show PRMT1 Antibodies)-mediated CPC regulation through methylation of INCENP.
The data suggest that INCENP in the chromosomal passenger complex pathway contributes to estrogen receptor (show ESR1 Antibodies)-negative breast cancer susceptibility in the European population.
Our results provide the structural basis and energetics of the human Aurora-A (show AURKA Antibodies)(G198N) - INCENP complex
v-Src (show SRC Antibodies) induces the failure of cytokinesis and the delocalization of Mklp1 (show KIF23 Antibodies), Aurora B (show AURKB Antibodies), and INCENP from the spindle midzone.
HP1alpha (show CBX5 Antibodies) binding by INCENP or Shugoshin 1 (Sgo1 (show SGOL1 Antibodies)) is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet unknown interphase functions of the chromosome passenger complex (CPC) or Sgo1 (show SGOL1 Antibodies) at the centromeres.
Results indicate that INCENP-Aurora B (show AURKB Antibodies) localized at centromeres/inner kinetochores is sufficient to mediate SAC (show ADCY10 Antibodies) activity upon spindle disruption.
Dephosphorylation of INCENP at anaphase and the concomitant relocation of the chromosomal passenger protein complex prevents kinetochore recruitment of mitotic checkpoint (show BUB3 Antibodies) proteins.
Data show that binding to INCENP is alone critical to the distinct function of Aurora B (show AURKB Antibodies), and although G198 of Aurora A (show AURKA Antibodies) is required for TPX2 (show TPX2 Antibodies) binding, N142G Aurora B (show AURKB Antibodies) retains INCENP binding and Aurora B (show AURKB Antibodies) function.
Aurora B kinase (show AURKB Antibodies) activity is stimulated by INCENP and C-terminal region of INCENP is sufficient for activation
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A\; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994
inner centromere protein antigens 135/155kDa
, inner centromere protein B
, inner centromere protein
, similar to XL-INCENP
, inner centromere protein-like
, class I INCENP protein
, class II INCENP protein
, binds and activates aurora-B and -C in vivo and in vitro
, chromosomal passenger protein
, inner centromere protein INCENP