INCENP antibody (AA 231-398)

Catalog No. ABIN2668314

This Mouse Monoclonal antibody specifically detects INCENP in IF and ICC. It exhibits reactivity toward Human and Mouse.It has been mentioned in 1 publication

Quick Overview for INCENP antibody (AA 231-398) (ABIN2668314)

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This INCENP antibody is un-conjugated

Application: Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 58-217-2

Product Details anti-INCENP Antibody

Binding Specificity: AA 231-398

Purpose: INCENP antibody (mAb) (Clone 58-217-2)

Purification: Protein A Chromatography

Immunogen: This INCENP antibody was raised against a recombinant protein corresponding to amino acid residues 231-398 of human INCENP.

Isotype: IgG1

Application Details

Application Notes: ICC/IF: 1:500 - 1:1,000 dilution

Restrictions: For Research Use only

Handling

Concentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

References for anti-INCENP antibody (ABIN2668314)

Wang, Ballister, Lampson: "Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient." in: The Journal of cell biology, Vol. 194, Issue 4, pp. 539-49, (2011) (PubMed).

Target Details for INCENP

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Alternative Name: INCENP

Background: INCENP (Inner Centromere Protein) is part of the chromosomal passenger complex that associates with chromosomes and regulates mitosis and meiosis. INCENP forms a scaffold holding the CP complex together and plays a role in the regulation of Aurora B and Aurora C kinase activity.

Molecular Weight: 140 kDa

Gene ID: 3619

NCBI Accession: NP_001035784

Pathways: Cell Division Cycle