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Human Monoclonal GCLC Primary Antibody for IF, ELISA - ABIN561050
Hardwick, Fisher, Canet, Lake, Cherrington: Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease. in Drug metabolism and disposition: the biological fate of chemicals 2010
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Cow (Bovine) Polyclonal GCLC Primary Antibody for IHC, WB - ABIN2785780
Bardag-Gorce, Oliva, Lin, Li, French, French: Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. in Experimental and molecular pathology 2011
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Arabidopsis thaliana Polyclonal GCLC Primary Antibody for IL, WB - ABIN190704
Ghanta, Bhattacharyya, Sinha, Banerjee, Chattopadhyay: Nicotiana tabacum overexpressing γ-ECS exhibits biotic stress tolerance likely through NPR1-dependent salicylic acid-mediated pathway. in Planta 2011
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Cow (Bovine) Polyclonal GCLC Primary Antibody for IHC, WB - ABIN2774078
Jönsson, Jönsson, Axmon, Littorin, Broberg: Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries. in International archives of occupational and environmental health 2008
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Cow (Bovine) Polyclonal GCLC Primary Antibody for IP, WB - ABIN4313738
Theodoratos, Blackburn, Cappello, Tummala, Dahlstrom, Board: Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase. in Biochemical pharmacology 2011
we report phenotypic analysis of a complete loss-of-function mutant in the gamma-glutamylcysteine synthetase catalytic subunit (Gclc) gene in the fruit fly Drosophila melanogaster.Gclc encodes the evolutionarily conserved catalytic component of the enzyme that conjugates glutamate (show GRIN2A Antibodies) and cysteine in the GSH biosynthesis pathway.
Microarray analysis revealed that glutamate (show GRIN2A Antibodies) cysteine ligasec overexpression and thus enhanced glutathione production has a broad impact on gene expression that largely affects different processes in young and old flies.
investigation of mutations in GCL modifier subunit and the GCL catalytic subunit that modify catalytic activity and lower glutathione levels
Neuronal overexpression of GCLc in a long-lived background extended mean and maximum life spans up to 50%, without affecting the rate of oxygen consumption by the flies
The reversibility of the dephosphorylation-dependent activation was indicated by the time-dependent inactivation of the in vitro activated Drosophila GCL, by preincubation with MgATP.
that the longevity effects of GCLc are dependent on dosage and that there are specific tissues (mushroom bodies, motor neurons, and transverse muscle cells) particularly sensitive to the benefits of GCLc overexpression.
GSH biosynthesis in the nucleus is associated with migration of only the GCLc subunit from the cytoplasm into the nucleus, and this migration requires the presence of an intact nuclear localization signal
the present study demonstrated that cells transformed by chronic exposure to 3MC exhibited inhibition of GSH biosynthesis by suppression of GCL protein expression and reduction of cysteine availability, which may subsequently render cells vulnerable to oxidative stress.
Glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response in THP-1 (show GLI2 Antibodies) macrophages is tightly and differentially regulated via GCLC and GCLM (show GCLM Antibodies) subunits of glutamate cysteine ligase.
High expression of GCLC in tumor tissue may be a potential predictor of treatment failure.
gamma-GCS has a role in chemo- and radio-resistance of human hepatocellular carcinoma cells
The findings indicate that expression of the transcription factor NRF2 and its effector GCL are both profoundly deregulated in endometriotic lesions towards increased growth and fibrogenetic processes.
Taken together, our findings provide evidence that G9a (show EHMT2 Antibodies) protects head and neck squamous cell carcinomas (HNSCC)cells against chemotherapy by increasing the synthesis of GSH, and imply G9a (show EHMT2 Antibodies) as a promising target for overcoming cisplatin resistance in HNSCC
A panel consisting of IGFBP1 (show IGFBPI Antibodies), KIM1 (show HAVCR1 Antibodies), GCLC and GSTM1 (show GSTM1 Antibodies) genes could be used in combination for early screening of CKDu, whereas these genes in addition with FN1 (show FN1 Antibodies), IGFBP3 (show IGFBP3 Antibodies) and KLK1 (show KLK1 Antibodies) could be used to monitor progression of CKDu. The regulation of these genes has to be studied on larger populations to validate their efficiency for further clinical use.
High GCLC expression is associated with chemotherapy resistance in breast cancer.
Knockdown of CD44 (show CD44 Antibodies) reduced the protein level of xCT (show SLC7A11 Antibodies), a cystine transporter, and increased oxidative stress. However, an increase in GSH was also observed and was associated with enhanced chemoresistance in CD44 (show CD44 Antibodies)-knockdown cells. Increased GSH was mediated by the Nrf2 (show GABPA Antibodies)/AP-1 (show FOSB Antibodies)-induced upregulation of GCLC, a subunit of the enzyme catalyzing GSH synthesis
GCLC polymorphisms correlated with brain GSH and Glu (show DCTN1 Antibodies) levels in psychosis.
Retinal GCLC was significantly increased in rd10 (show PDE6B Antibodies) mice at P21 (show D4S234E Antibodies) as well as GSSG. Our results suggest alterations in retinal GCLC content and GSH and/or its precursors in these two RP animal models. Regulation of the enzymes related to GSH metabolism and the retinal concentration of glutamate (show GRIN1 Antibodies) may be a possible target to delay especially cone death in Retinitis Pigmentosa
Data show that the catalytic subunit of glutamate cysteine ligase (Gclc)-derived glutathione buffers reactive oxygen species (ROS (show ROS1 Antibodies)), and regulates metabolic reprogramming.
To study the biological effects of low GSH levels, we disrupted its synthesis both at birth by breeding a Gclc loxP mouse with a thy1 (show THY1 Antibodies)-cre mouse and at a later age by breeding with a CaMKII (show CAMK2G Antibodies)-ERT2 (show MAPK3 Antibodies)-Cre (FIGSKO mouse). FIGSKO mice also develop cognitive abnormalities, i.e. learning impairment and nesting behaviors based on passive avoidance, T-Maze, and nesting behavior tests
A floxed Gclc mouse was generated and crossed with a transgenic mouse expressing Cre in the lens to generate the Lens Glutathione Synthesis Knockout mouse in which de novo GSH synthesis was completely abolished in the lens.
Clinically relevant levels of TGF-beta1 (show TGFB1 Antibodies) suppresses GCLC and GCLM (show GCLM Antibodies) expression in mouse lung.
Data show for the first time that GCLC may serve a dual role, as a surrogate marker for cellular redox state as well as malignant potential of melanoma cells.
The impacts of four clinical missense mutations on GCLC enzymatic function in vivo and in vitro, was evaluated.
tBHQ has beneficial effects on reducing hyperglycemia-induced kidney injury, which is associated with the enhanced expression of Nrf2 (show NFE2L2 Antibodies), and its downstream antioxidant HO-1 (show HMOX1 Antibodies) and gamma-GCS (show UGCG Antibodies) in the glomeruli of diabetic mice
In first days of life luminescence measured was in all mice with distinct strain differences indicating NF-kappaB (show NFKB1 Antibodies), superoxide dismutase (show SOD1 Antibodies), gamma-glutamylcysteine synthetase, and antioxidant responsive element activity.
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.
glutamate--cysteine ligase catalytic subunit
, glutamate-cysteine ligase, catalytic subunit
, gamma-Glutamylcysteine synthetase
, gamma-Glutamylcysteine synthetase catalytic subunit
, gamma-glutamylcysteine ligase
, glutamate cysteine ligase
, glutamate-cysteine ligase
, gamma glutamylcysteine synthetase
, glutamate--cysteine ligase, chloroplastic
, GCS heavy chain
, gamma-glutamylcysteine synthetase
, gamma GCS-HS
, gamma-glutamylcysteine synthetase heavy subunit
, Glutamylcysteine gamma synthetase light chain
, glutamate-cysteine ligase catalytic subunit