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A role of GPx2 (show GPX2 Proteins), TrxR2 (show TXNRD2 Proteins) and TrxR3 in proliferation, apoptosis and, therefore, also during cancer development.
This study pertains to use of non-AUG (CUG) start codon in mouse thioredoxin reductase 3 gene, and conservation of this site in other mammals.
Study shows that CUG codon is used as an inefficient start codon to generate protein Thioredoxin/glutathione reductase isoforms in mouse.
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
thioredoxin reductase 3
, thioredoxin and glutathione reductase
, thioredoxin glutathione reductase
, thioredoxin reductase 2
, thioredoxin reductase TR2