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Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073
Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992
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Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305077
Feng, Tang, Chang, Wilson: Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10) cDNA and expression in spleen and macrophages. in Biochemical and biophysical research communications 1993
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418
van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072
Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991
Show all 2 Pubmed References
Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988023
Yang, Hirose, Takahashi, Kawakatsu, Takaiwa: Recombinant protein yield in rice seed is enhanced by specific suppression of endogenous seed proteins at the same deposit site. in Plant biotechnology journal 2012
Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988022
Larson, Hübner, Torrero, Morris, Brankin, Swierczewski, Davies, Vonakis, Mitre: Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. in Journal of immunology (Baltimore, Md. : 1950) 2012
IL-33 (show IL33 Proteins) increased IL-10 expression in MFCs via activating ERK 1 (show MAPK3 Proteins)/2 and STAT3 (show STAT3 Proteins), which subsequently promoted IL-10 transcription and thus contributed to the beneficial effects of IL-33 (show IL33 Proteins) on MFCs.
theses results suggest that IL-10 genotypes of recipient are the most associated with the risk of complications after haematopoietic stem cell transplantation
serum concentrations of IL-6 (show IL6 Proteins) and IL-10 but not TNFa (show TNF Proteins) in patients with internal carotid artery stenosis allow to predict the progression of the degree of stenosis and the unfavorable change of atherosclerotic plaque morphology
Our results suggest that genetic variation in IL-10 gene is unlikely to confer susceptibility to Henoch-Schonlein purpura in Chinese children.
neither allele nor genotype frequencies of IL-10 polymorphisms were associated with inflammatory bowel disease in Iranian patients
According to our data, TNF A (show TNF Proteins) -238G>A and IL-10 -1082A>G, -819C>T and -592C>A may be associated with the development of prostate cancer and BPH (show GLI3 Proteins). We could also notice higher frequency of TNF A (show TNF Proteins) and IL-10 risk haplotypes in smoker and alcohol user. Interestingly, IL-10 risk haplotype was positively associated with aggressiveness of tumor.
Local IL-10 and IL-13 (show IL13 Proteins) upregulation in IgG4-abdominal aortic aneurysms was related to Th2 and Treg-predominant cytokine balance.
Suggest that the interaction between macrophages and endometrial stromal cells downregulates cytotoxicity of NK cells possibly by stimulating the secretion of IL-10 and TGF-beta (show TGFB1 Proteins), and may further trigger the immune escape of ectopic fragments and promote the occurrence and the development of endometriosis.
isatuximab decreases multiple myeloma cell- and bone marrow stromal cell-induced iTreg by inhibiting both cell-cell contact and TGFbeta/IL10. Finally, CD38 levels correlate with differential inhibition by isatuximab of Tregs from multiple myeloma versus normal donors.Targeting CD38 by isatuximab can preferentially block immunosuppressive Tregs and thereby restore immune effector function against multiple myeloma
Activation of PAR2 (show F2RL1 Proteins) inhibits the expression of IL-10 in B cells, which can be reversed by treating B cells with Bcl2L12 (show BCL2L12 Proteins) shRNA-carrying liposomes.
this study demonstrates IL-10 production and T cell-suppressive capacity in B cell subsets from atherosclerotic apoE (show APOE Proteins) (-/-) mice
IL-10 Knock out-Endothelial progenitor cell-Exosomes were highly enriched in microRNAs and proteins that promote inflammation and apoptosis and inhibit angiogenesis.
we showed the IL-10 expression of the pyramidal neurons in CA2 (show CA2 Proteins) and CA3 (show CA3 Proteins) subregions, for the first time in the world, after infection with the Mu-3 virus
These data indicate that CD4 (show CD4 Proteins)(+) follicular regulatory T (Tfr (show TFRC Proteins)) cells play a multifaceted role in the fine-tuning of the germinal center response and identify IL-10 as an important mediator by which Tfr (show TFRC Proteins) cells support the germinal center reaction
Decreased interleukin-10 (IL-10) expression was found in the hippocampus of the stressed mice, while no differences in pro-inflammatory cytokine expression and tryptophan (TRYP), kynurenine (KYN) or 3-hydroxy kynurenine (3-HK) levels were found.
HBV-specific CD8 (show CD8A Proteins)(+) T cells produce IL-10 upon antigen recognition and that this cytokine enhances CD8 (show CD8A Proteins)(+) T cell survival.
Novel regulatory T-cells that are induced by B cells and do not express Foxp3 (show FOXP3 Proteins) and IL-10 alleviate intestinal inflammation in vivo.
Results provide evidence that macrophage IL-10 production is regulated by NLRP3 (show NLRP3 Proteins) and contributes to the pathophysiology of doxorubicin-induced cardiotoxicity independently of IL-1beta (show IL1B Proteins).
Activation of TLR2, TLR4 (show TLR4 Proteins), and TLR9 (show TLR9 Proteins) induced the production of IL-10 in microglia to a greater extent than activation of TLR3 (show TLR3 Proteins). Combination of TLR3 (show TLR3 Proteins) triggering with the other TLRs, enhanced IL-10 through the modulation of its transcription, via interferon (show IFNA Proteins) (IFN)-beta (show IFNB1 Proteins), but independently of IL-27 (show IL27 Proteins). Presence of IFN-gamma (show IFNG Proteins) in the microenvironment abrogated the modulation of IL-10 by TLR3 (show TLR3 Proteins), whereas that of IL-17 (show IL17A Proteins) had no effect.
The absence of IL-10 led to longer illness, more weight loss, more death, and slower viral clearance than in mice that produced IL-10. IL-10 influenced development of disease-causing T cells and entry into the brain of B cells producing antiviral antibody.
Studied expression of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows. Found IL-10 expression to be significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones.
This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.
IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.
Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll (show TLR4 Proteins) like receptor activation.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3 (show SOCS3 Proteins), which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma (show IFNG Proteins) production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
serum IL-6 (show IL6 Proteins):IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (show IL6 Proteins), IL-10 and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.
ICAM1 (show ICAM1 Proteins) and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (show JUN Proteins) may be responsible for this upregulation.
The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.
These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10, and IL-6 (show IL6 Proteins) in ovarian follicles are reported.
Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma (show IFNG Proteins)+CD4 (show CD4 Proteins)+ regulatory T cells to control transplant arteriosclerosis.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK (show MAPK14 Proteins) activation.
Boar seminal plasma contained TGF- beta1 (show TGFB1 Proteins) and IL-10 but with high individual variation.
Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.
These results suggest that TNF-alpha (show TNF Proteins) and IL-10, but not IL-6 (show IL6 Proteins), are involved in the late reparatory phases of the experimental disk lesion.
The present study shows that elevated levels of serum CRP (show CRP Proteins) and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)
Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.
IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS (show NTS Proteins), which may contribute to differences in the clinical presentation of NTS (show NTS Proteins) infection in the setting of malaria.
Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.
IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha (show TNF Proteins) cytokine production.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
T-cell growth inhibitory factor
, cytokine synthesis inhibitory factor
, uncharacterized protein LOC100715618
, Cytokine synthesis inhibitory factor