Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073
Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992
Show all 4 Pubmed References
Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305077
Feng, Tang, Chang, Wilson: Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10) cDNA and expression in spleen and macrophages. in Biochemical and biophysical research communications 1993
Show all 3 Pubmed References
Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418
van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 3 Pubmed References
Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072
Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991
Show all 2 Pubmed References
Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988020
Larson, Hübner, Torrero, Morris, Brankin, Swierczewski, Davies, Vonakis, Mitre: Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. in Journal of immunology (Baltimore, Md. : 1950) 2012
Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988023
Yang, Hirose, Takahashi, Kawakatsu, Takaiwa: Recombinant protein yield in rice seed is enhanced by specific suppression of endogenous seed proteins at the same deposit site. in Plant biotechnology journal 2012
The present study suggests that the IL10 -819(C/T), -1082(G/A) and -592(C/A) polymorphisms and the haplotypes are associated with Systemic lupus erythematosus susceptibility, increased disease activity and elevated IL10 levels. While this is the first time to report such an association in an Iranian population, further studies are needed to confirm these findings.
Polymorphisms in the IL-10 gene are associated with protective effect against rheumatoid arthritis (RA) and periodontal disease in male patients who have citrullinated proteins antibody (CPP) present in bloodstream.
our study confirmed the correlation of IL-10 with cardiac ejection fraction by our follow-up echocardiography assessment that was performed 2 months after the incidence of Myocardial infarction .
IL-10 SNPs rs1800896, rs3021097, and rs1800872 are not associated with risk of psoriasis.
In Parkinson's disease-related pain patients, the levels of interleukin-10 in peripheral blood are depressed.
associations of IL-8-251A/T (rs4073) and IL-10 -592C/A (rs1800872) with CAD in the North Indian population
IL-10 rs1800896, rs1800871,and rs1800872 variants, along with specific (2-loci) haplotypes contribute to the development of Nasopharyngeal Cancer. IL-10 rs1800871 and AT haplotype may be used for detection of subjects at higher risk of Laryngeal cancer.
Studied association of interleukin 10 (IL-10) haplotypes with susceptibility to diabetic nephropathy in Mexican patients.
The objective of this study was to evaluate the associations between IL10 single nucleotide polymorphisms (SNPs) at rs1800890 (- 3575A/T), rs1800871 (- 819C/T) or rs1800872 (- 592C/A) either alone or combined with the SNP at rs1800896 (- 1082G/A), and the etiology and severity of infant bronchiolitis. IL10 rs1800890 and rs1800896 polymorphisms differed between infants with rhinovirus bronchiolitis and controls.
Human regulatory dendritic cells (DCreg) were generated from CD14 immunobead-purified or elutriated monocytes in the presence of vitamin D3 and IL-10. They exhibited similar, low levels of costimulatory CD80 and CD86, but comparatively high levels of co-inhibitory programed death ligand-1 (PD-L1) and IL-10 production compared to control immature DC (iDC).
no significant differences in bacterial load were found in patients carrying periodontal disease susceptibility alleles of IL6, IL10 and VDR genes
Results found that promoter polymorphisms of IL-10 have been significantly associated with intervertebral disc degeneration in Iranian population.
Study suggests that asthma is significantly associated with higher differentially methylated regions within region 3 of intron 4 of IL10.
The IL10 may function as a biomarker for immunoregulation in AFB1-exposed GD patients.
Low IL10 expression is associated with early stage invasive breast cancer.
Overall, there was no significant association between IL-10 -1082A>G polymorphism and breast cancer risk under all genetic models. Moreover, there was no significant association between the IL-10 -1082A>G polymorphism and breast cancer risk by ethnicity.
IL-10-producing Foxp3(neg) CD4(+) T cells have a unique transcriptional program, which goes beyond the regulation of IL-10 expression. Patients with inflammatory bowel disease demonstrate a deficiency in this specific regulatory T-cell subpopulation.
IL-10 attenuates the Neisseria meninigitidis-stimulated increase in MyD88-dependent pro-inflammatory cytokines
IL-10-1082G/A gene polymorphism is associated with recurrent oral ulcer (ROU) susceptibility. Individuals with G allele and GA genotype have a higher risk of ROU [meta-analysis]
the IL-10 expression level and the STAT3 activation level were significantly higher in MYD88 L265P mutant lymphomas than in MYD88 WT lymphomas.
Resolution of inflammation-induced depression is an active process requiring T lymphocytes acting via an IL-10 dependent pathway in the brain.
commensal bacteria influence STING signaling predominantly in mononuclear phagocytes to produce both pro-inflammatory cytokines as well as anti-inflammatory IL-10.
The functional shortage of NK cells and inappropriate expression of IL10 result in the susceptibility to mouse cytomegalovirus in BALB/c mice.
IL-10-producing CD4(+) T cells are phenotypically and functionally heterogeneous.
Despite being coexpressed, IL-10 and IL-24 are independently regulated by different type I IFN receptor signaling pathways.
L-EVs were effective at inhibiting OVA peptide-specific CD4(+) T cell proliferation in a TGF-beta1- and IL-10-dependent manner.
CD103(+) cDCs counterregulated CD11b(+) cDC-mediated Th1 activation directly by producing the immune-suppressive cytokine IL-10.
Locus-specific reversible DNA demethylation may serve as a threshold platform to control transient Il-10 gene expression.
IL-10-induced STAT3 increases S1pr1 expression.
IL-10 induction in B cells was regulated by an ERK1/2- and p90 ribosomal S6 kinase-dependent mechanism, unlike in macrophages in which p90 ribosomal S6 kinase was not required.
glycine exposure enhanced the mRNA levels of adipose-derived adiponectin and IL-10 without affecting adipogenesis and lipolysis in 3T3-L1 adipocytes.
Interleukin 10 suppresses lysosome-mediated killing of Brucella abortus in cultured macrophages
Mice lacking IL-10 have increased energy expenditure and adipose thermogenesis. IL-10 affects chromatin structure and C/EBPbeta and ATF occupancy at thermogenic genes.
G protein-coupled receptor 39 exhibits an anti-inflammatory activity by enhancing IL-10 production from macrophages
our results provide direct evidence that the capacity of NK cells to secrete IL-10 is required to maintain the successful "innate" modulation of DC phenotype in the gravid uterus.
Restrictive IL-10 induction by an innocuous parainfluenza virus vector ameliorates nasal allergy.
a regulatory loop in which IL-10 directly restricts CD8(+) T cell activation and function through modification of cell surface glycosylation allowing the establishment of chronic infection.
genome-wide knockdown of 19 ribosomal proteins resulted in decreased IL-10 and increased TNF-alpha production.
YB-1 orchestrates onset and resolution of renal inflammation via IL-10 gene regulation.
this study demonstrates IL-10 production and T cell-suppressive capacity in B cell subsets from atherosclerotic apoE (-/-) mice
Studied expression of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows. Found IL-10 expression to be significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones.
This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.
IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.
Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll like receptor activation.
Levels in milk are altered in the presence of bacteria.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
serum IL-6:IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
The effect of clenbuterol on cytokine metabolism in the peripheral white blood cells in those horses with small airway diseases that have been exposed to lipopolysaccharides is reported.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.
Single nucleotide polymorphisms on exon 3 were significantly associated with immune traits.
ICAM1 and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 may be responsible for this upregulation.
In contrast to lung tissue, in which Actinobacillus pleuropneumoniae (APP) presence was associated with a pronounced pro-inflammatory character, APP presence in the tonsils elicited an increased IL-10 expression.
The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.
These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.
Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma+CD4+ regulatory T cells to control transplant arteriosclerosis.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK activation.
Boar seminal plasma contained TGF- beta1 and IL-10 but with high individual variation.
Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.
These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)
Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.
Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping.
findings show that Brachyspira hyodysenteriae inoculation induced production of systemic levels of IL-1beta during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery
IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS, which may contribute to differences in the clinical presentation of NTS infection in the setting of malaria.
Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.
IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha cytokine production.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
T-cell growth inhibitory factor
, cytokine synthesis inhibitory factor
, uncharacterized protein LOC100715618
, Cytokine synthesis inhibitory factor