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Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305073
Howard, OGarra, Ishida, de Waal Malefyt, de Vries: Biological properties of interleukin 10. in Journal of clinical immunology 1992
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN413418
van der Vliet, Wang, Yue, Koon, Balk, Exley: Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Rat (Rattus) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305077
Feng, Tang, Chang, Wilson: Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10) cDNA and expression in spleen and macrophages. in Biochemical and biophysical research communications 1993
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Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN1305072
Vieira, de Waal-Malefyt, Dang, Johnson, Kastelein, Fiorentino, deVries, Roncarolo, Mosmann, Moore: Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI. in Proceedings of the National Academy of Sciences of the United States of America 1991
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Mouse (Murine) IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988020
Larson, Hübner, Torrero, Morris, Brankin, Swierczewski, Davies, Vonakis, Mitre: Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner. in Journal of immunology (Baltimore, Md. : 1950) 2012
Human IL-10 Protein expressed in Escherichia coli (E. coli) - ABIN988023
Yang, Hirose, Takahashi, Kawakatsu, Takaiwa: Recombinant protein yield in rice seed is enhanced by specific suppression of endogenous seed proteins at the same deposit site. in Plant biotechnology journal 2012
interleukin-10-1082G>A, -592C>A, and -819C>T polymorphisms are correlated with the susceptibility to rheumatoid arthritis [meta-analysis]
In adult patients with shingles, genotype TT of the interleukin-10 gene was associated with a risk of the development of severe complicated course of shingles.
Letter: fecal il10 expression is not altered in symptomatic uncomplicated diverticular disease of the colon.
In patients with periodic disease (both colchicin-resistant and colchicin-sensitive) increased serum concentration of IL-10 was accompanied by an increased level of IL-6 in serum.
KCa3.1 activators have potential as a therapeutic option to suppress the tumor-promoting activities of IL-10.
the IL-10 -592A>C polymorphism, but not -819T>C polymorphism, may be contributed to the susceptibility of gastric cancer in overall and Asian populations (Meta-Analysis)
Increased HLA-G and IL-10 expression in a group of acral lentiginous melanomas compared with a group of superficial spreading melanomas were related to the histopathological features predictive of unfavorable prognosis in cutaneous melanoma and metastasis.
Study shows that mitochondria of the brown adipose tissue are severally damaged at the structural and functional levels in IL10 deficiency. Both IL10 deficiency, and systemic inflammation, which originated as a result of the immune imbalance resulting from the lack of IL10, act in combination to damage mitochondria. The abnormal activity of the IL10 may contribute to defects in energy metabolism in medical conditions.
tear cytokines showed 2.8 times lower levels of IL-10 than TNF-alpha in perennial allergic conjunctivitis patients when compared to healthy controls.
The miR-199-3p was shown to target PARP-1 to activate the ERK1/2 pathway and promote IL-10 production, restoring physiological miR-199-3p levels could represent a potential therapeutic strategy for SLE treatment.
We confirmed the association of Sjogren's syndrome with the STAT4 and IL10 genes and we describe a novel association with HCP5.
Low blood content of IL-10-producing CD4(+) T cells is a risk factor for progression of coronary atherosclerosis.
The functional -1082A/G polymorphism in IL10 is associated with risk of renal parenchymal damage/reduction rather than genetic predisposition to CAKUT.
We have identified rs1800896 (or a variant in strong LD with it) as the underlying causal variant within the IL10 locus and disclosed the suppression of immune responses to Aspergillus fumigatus as the primary mechanism explaining the increased susceptibility to infection.
An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (IL-4, Il-10, TGFB1) occurs in women with endometriosis. (Review)
Highlighting the role of IL-10 cytokine in the pathogenesis of psoriasis will help in the development of psoriasis management
The study found no significant differences between Takayasu arteritis and healthy controls in the frequency of any of the variations in the SNPs of IL-6 and IL-10 genes. The expression levels of both cytokines were associated with the disease status, indicating that they may serve as potential biomarkers for monitoring disease activity.
hypermethylation of promoter region was the principal defect for the IL-10 mRNA low expression in patients with Behcet's disease.
siRNAs for CD5 or for TRPC1 inhibit IL-10 production.
this study shows that genetic polymorphisms in IL-10 are associated with an increased risk of cervical cancer in Chinese women
Loss of interleukin 10 (IL10) expression in transgenic mice expressing catalytically inactive RAG1 (dnRAG) mice had no significant effect on B10-like B cell expansion.
Bhlhe40 is required to repress Il10 expression during Mycobacterium tuberculosis infection.
these findings demonstrate that IL-10 is pivotal to prevent gluten-induced small intestinal inflammation and epithelial damage
This study demonstrated that astrocyte-targeted IL-10 production induces significant changes in the activation pattern of microglia/macrophage cell population after transection of perforant pathway.
These data suggest a potent regulatory role of IL-10 in the cross-reactive memory response to the infection with heterologous Plasmodium parasites leading to the inhibition of the protective immunity and pathogenesis.
B cells are the major producers of IL-10 in-vivo. In regulatory B cells, BATF, IFN regulatory factor, and IRF-8 transcription factors were recruited and bound to AP1-IRF-composite elements of il12a, ebi3, and/or il10 loci.
IL-10 can directly alter gonadotropin-releasing hormone neuron firing and induce ERK1/2 phosphorylation
Incorporation of IL-10 blocking agents may enhance current therapeutic regimens for CLL by potentiating host antitumor immune response.
Genetic deletion of 4E-BP1/2 in macrophages increased endogenous IL-10.
Resolution of inflammation-induced depression is an active process requiring T lymphocytes acting via an IL-10 dependent pathway in the brain.
commensal bacteria influence STING signaling predominantly in mononuclear phagocytes to produce both pro-inflammatory cytokines as well as anti-inflammatory IL-10.
The functional shortage of NK cells and inappropriate expression of IL10 result in the susceptibility to mouse cytomegalovirus in BALB/c mice.
IL-10-producing CD4(+) T cells are phenotypically and functionally heterogeneous.
Despite being coexpressed, IL-10 and IL-24 are independently regulated by different type I IFN receptor signaling pathways.
L-EVs were effective at inhibiting OVA peptide-specific CD4(+) T cell proliferation in a TGF-beta1- and IL-10-dependent manner.
CD103(+) cDCs counterregulated CD11b(+) cDC-mediated Th1 activation directly by producing the immune-suppressive cytokine IL-10.
Locus-specific reversible DNA demethylation may serve as a threshold platform to control transient Il-10 gene expression.
IL-10-induced STAT3 increases S1pr1 expression.
IL-10 induction in B cells was regulated by an ERK1/2- and p90 ribosomal S6 kinase-dependent mechanism, unlike in macrophages in which p90 ribosomal S6 kinase was not required.
glycine exposure enhanced the mRNA levels of adipose-derived adiponectin and IL-10 without affecting adipogenesis and lipolysis in 3T3-L1 adipocytes.
Studied expression of Interleukin 10 (IL-10) in blood and milk samples of 25 healthy and 25 mastitic cows. Found IL-10 expression to be significantly higher in the blood and milk samples of mastitic cows compared to the healthy ones.
This study seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10.
IL-10 mRNA expression increased on day 8 in the mononuclear leukocytes of pregnant cows. In a cell culture experiment, interferon-tau stimulated stimulated IL-10 mRNA expression in mononuclear leukocytes.
Bovine IL-10 potently inhibits the activation of human myeloid cells in response to toll like receptor activation.
Levels in milk are altered in the presence of bacteria.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
serum IL-6:IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
The effect of clenbuterol on cytokine metabolism in the peripheral white blood cells in those horses with small airway diseases that have been exposed to lipopolysaccharides is reported.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
The complete open reading frame consists of 537 base pairs which encodes a protein of 179 amino acids. This cDNA sequence exhibited 87% homology with human IL-10.
Single nucleotide polymorphisms on exon 3 were significantly associated with immune traits.
ICAM1 and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 may be responsible for this upregulation.
In contrast to lung tissue, in which Actinobacillus pleuropneumoniae (APP) presence was associated with a pronounced pro-inflammatory character, APP presence in the tonsils elicited an increased IL-10 expression.
The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed.
These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.
Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma+CD4+ regulatory T cells to control transplant arteriosclerosis.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK activation.
Boar seminal plasma contained TGF- beta1 and IL-10 but with high individual variation.
Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model.
These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.
The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome)
Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.
Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping.
findings show that Brachyspira hyodysenteriae inoculation induced production of systemic levels of IL-1beta during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery
IL-10 produced during the immune response to malaria in this model contributes to suppression of mucosal inflammatory responses to invasive NTS, which may contribute to differences in the clinical presentation of NTS infection in the setting of malaria.
Findings demonstrate that internalization of IL-10R with the resultant impact on IL-10 signaling and dysregulation of the IL-10-mediated anti-inflammatory responses might play a crucial role in epithelial cell damage and subsequent simian immunodeficiency virus pathogenesis.
IL-10 plays a crucial role in maintaining mucosal homeostasis by regulating mucosal IFNgamma and TNFalpha cytokine production.
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
T-cell growth inhibitory factor
, cytokine synthesis inhibitory factor
, uncharacterized protein LOC100715618
, Cytokine synthesis inhibitory factor