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anti-Mouse (Murine) BCL6 Antibodies:
anti-Human BCL6 Antibodies:
anti-Rat (Rattus) BCL6 Antibodies:
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Human Monoclonal BCL6 Primary Antibody for IHC (p), ICS - ABIN967677
Baumjohann, Okada, Ansel: Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 10 Pubmed References
Human Monoclonal BCL6 Primary Antibody for IHC, WB - ABIN2668887
García, García, Maestre, Lucas, Sánchez-Verde, Romero-Chala, Piris, Roncador: Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005
Show all 2 Pubmed References
Human Polyclonal BCL6 Primary Antibody for IF (p), IHC (p) - ABIN749843
Szabó, Gáspár, Dajnoki, Papp, Fábos, Szegedi, Zeher: Expansion of circulating follicular T helper cells associates with disease severity in childhood atopic dermatitis. in Immunology letters 2017
Human Polyclonal BCL6 Primary Antibody for WB - ABIN4283623
Margalit, Amram, Amariglio, Simon, Shaklai, Granot, Minsky, Shimoni, Harmelin, Givol, Shohat, Oren, Rechavi: BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma. in Blood 2006
BCL6 forms a complex with BCL6 corepressor (BCoR (show BCOR Antibodies)) on the promoters of selected Notch (show NOTCH1 Antibodies) target genes such as enhancer of split related 1.
The balance between CD4 (show CD4 Antibodies)(+) cytotoxic T cell and follicular helper T(Tfh) differentiation heavily depends on the class of infecting virus and is jointly regulated by the Tfh-related transcription factors Bcl6 and Tcf7 (show TCF7 Antibodies) (encoding TCF-1 (show HNF1A Antibodies)) and by the expression of the inhibitory receptors PD-1 (show PDCD1 Antibodies) and LAG3 (show LAG3 Antibodies).
Study provides evidence for an essential role of Bcl6 in the complex regulation of gene transcription during early adipogenesis. The action of Bcl6 is at least partially mediated by the direct transcriptional activation of STAT1 (show STAT1 Antibodies).
These data describe a novel regulatory mechanism through which STAT3 (show STAT3 Antibodies) and the Ikaros (show IKZF1 Antibodies) zinc finger transcription factors Aiolos (show IKZF3 Antibodies) and Ikaros (show IKZF1 Antibodies) cooperate to regulate Bcl-6 expression.
Our data reveal a regulatory role of BCL6 in inhibiting antiviral resistance factors in follicular Th cells
data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 (show PRDM1 Antibodies) control follicular helper T cell differentiation
both mouse and human B cells, IFN-gamma (show IFNG Antibodies) synergized with B cell receptor, toll (show TLR4 Antibodies)-like receptor, and/or CD40 (show CD40 Antibodies) activation signals to promote cell-intrinsic expression of the GC master transcription factor, B cell lymphoma 6 protein.
observations reveal that KLF6 (show KLF6 Antibodies) repress BCL6 to enhance macrophage inflammatory gene expression and function.
synergistic activity of Card11 (show CARD11 Antibodies) mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model
Bcl6, by interacting with the co-factors NcoR2 and HDAC3 (show HDAC3 Antibodies), plays a pivotal role in controlling IRF7 (show IRF7 Antibodies) induction and antiviral signaling priming.
Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (show STAT5A Antibodies) axis.
our work casts new light on the biology of mantle cell lymphoma (MCL (show FH Antibodies)), revealing the role of SOX11 (show SOX11 Antibodies) exerting a functional effect through the repression of BCL6 transcription in MCL (show FH Antibodies) cells
BCL6 inhibitors have been shown to exert potent effects against these tumor types. Moreover, mechanism-based combinations of BCL6 inhibitors with other agents have yielded synergistic and often quite dramatic activity. Hence, there is a compelling case to accelerate the development of BCL6-targeted therapies for translation to the clinical setting
High BCL6 expression is associated with good response to chemotherapy in acute lymphoblastic leukemia.
this study show that PATZ1 (show ZNF278 Antibodies) expression correlates positively with BAX (show BAX Antibodies) and negatively with BCL6 and survival in human diffuse large B cell lymphomas
BCL6 expression is present in isolated cortical neurons, granule cells in the cerebellum, scattered glial cells, and in some cells of the ependyma and choroid plexus.
We show that human follicular lymphomas are dependent on BCL6
Aberrant BCL6 expression was strongly associated with poor reproductive outcomes in IVF (show SCN5A Antibodies) cycles in women with unexplained infertility.
EBNA3C inhibits the transcriptional activity of the Bcl6 promoter through interaction with the cellular protein IRF4 (show IRF4 Antibodies).
Data show that MYC (show MYC Antibodies), BCL2 (show BCL2 Antibodies) and BCL6 translocation had no prognostic impact with respect to progression free survival (PFS) or overall survival (OS).
Data suggest that B-cell CLL/lymphoma 6 is a promising candidate as a single diagnostic biomarker for detection of endometriosis in women with otherwise unexplained infertility and may be associated with endometrial dysfunction, including progesterone resistance.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
B-cell CLL/lymphoma 6
, B-cell CLL/lymphoma 6 (zinc finger protein 51)
, B-cell lymphoma 6 protein
, zinc finger protein 51
, B-cell leukemia/lymphoma 5
, B-cell leukemia/lymphoma 6
, B-cell lymphoma 6 protein homolog
, B-cell lymphoma 5 protein
, B-cell lymphoma 6 protein transcript
, cys-his2 zinc finger transcription factor
, lymphoma-associated zinc finger gene on chromosome 3
, protein LAZ-3
, zinc finger and BTB domain-containing protein 27
, zinc finger transcription factor BCL6S