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It has been shown that chromatin localization of Mbd2 and Mbd3 is highly overlapping, and both proteins are interdependent for chromatin association.
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controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program
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Smek/Mbd3 interaction regulates neuronal gene expression and neuronal differentiation during cortical development.
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This work revealed the critical function of miR-134-Mbd3 axis on regulating reprogramming and pluripotency of induced pluripotent stem cells derived from the neural progenitor cells.
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Cigarette smoke induces proteosomal-mediated degradation of Mbd-3 in embryonic orofacial cells.
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Although MBD3/NuRD is not required for neural stem cell lineage commitment, it is required to repress inappropriate transcription in progenitor cells and neurons to facilitate appropriate cell lineage choice and differentiation programmes.
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overexpression facilitates NANOG-mediated reprogramming in neural stem cells
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Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 in individual morula embryos.
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cyclin-dependent kinase 2-associated protein 1 (CDK2AP1), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt signaling genes
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Study finds that Mbd3 and Brg1 antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy; furthermore, both Mbd3 and Brg1 play key roles in the biology of 5-hydroxymethylcytosine.
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the transactivation domain of c-Jun recruits Mbd3/NuRD to AP-1 target genes to mediate gene repression, and this repression is relieved by JNK-mediated c-Jun N-terminal phosphorylation
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Mbd3 helps restrict ES cells from differentiating towards the trophectoderm lineage and is an important epigenetic player in maintaining full pluripotency of mouse ES cells
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MBD3 protein is differentially expressed in principal neurons of the hippocampus and cortex, and in the adult retina.
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MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing
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Mbd3-deficient embryonic stem cells could be maintained in the absence of leukaemia inhibitory factor (LIF) and could initiate differentiation in embryoid bodies or chimeric embryos, but failed to commit to developmental lineages.
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These results demonstrate the importance of Mbd3/NuRD for the development of pluripotent cells in vivo.
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A 1072 base pair fragment of the MBD3 promoter is sufficient to drive expression in cell lines and primary cultured neurons.
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Chromatin immunoprecipitation shows that MBD3 is bound to the H19 DMD; MBD3-depleted preimplantation embryos have reduced cell numbers, suggesting a role for MBD3 in cell division.
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Methyl-CpG binding domain 3b (Mbd3b) protein is a novel binding partner of Evi1, i.e., a member of the Mi-2/NuRD histone deacetylase complex.
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Component of Nucleosome Remodelling and Histone Deacetylation (NuRD) co-repressor complex