Clvs1/2 antibody (C-Term)
The Rabbit Polyclonal anti-Clvs1/2 antibody has been validated for IF and WB. It is suitable to detect Clvs1/2 in samples from Human, Mouse and Rat.
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Catalog No. ABIN784598
Quick Overview for Clvs1/2 antibody (C-Term) (ABIN784598)
Target
Clvs1/2
(Clavesin 1/2 (Clvs1/2))
Reactivity
Human, Mouse, Rat
Host
Rabbit
Clonality
Polyclonal
Application
Immunofluorescence (IF), Western Blotting (WB)
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Binding Specificity
- C-Term
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Specificity
- Specific for the ~35 kDa Clavesin 1/2 protein doublet in Western blots of Rat brain lysate. Isoform-specific knock down in cultured hippocampal neurons indicates that the lower and upper bands are Clavesin 1 and 2, respectively.
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Cross-Reactivity (Details)
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Species reactivity (expected):Human and Mouse.
Species reactivity (tested):Rat. -
Purification
- Affinity Chromatography.
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Immunogen
- Synthetic peptide KLH-conjugated corresponding to amino acid residues from the C-terminal region of Rat Clavesin-1. Genename: CLVS1/2
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Isotype
- IgG
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS containing 50 % Glycerol.
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Handling Advice
- Avoid repeated freezing and thawing.
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Storage
- -20 °C
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Storage Comment
- Store the antibody undiluted (in aliquots) at -20 °C.
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- Clvs1/2 (Clavesin 1/2 (Clvs1/2))
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Background
- Clavesin (clathrin vesicle associated Sec14 protein) is a novel neuron specific protein that has recently been identified and shown to be required for normal morphology of late endosomes and/or lysosomes as lentiviral-mediated knockdown of clavesin in hippocampal neurons causes lysosomal defects (Katoh et al., 2009). Additionally, upregulation of clavesin in human hepatocellular carcinoma has recently been demonstrated thus making it a useful marker for this disease state (Zhao et al., 2008).Synonyms: C6orf212, C6orf213, CLVS1, CLVS2, CRALBPL, Cellular retinaldehyde-binding protein-like, RLBP1L1, RLBP1L2, Retinaldehyde-binding protein 1-like 1/2
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Gene ID
- 366311
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NCBI Accession
- NP_001102439
Target
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