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Pericardial cells that express the transcription factor Even Skipped adopt distinct fates along the anterior-posterior axis. Among them, the most anterior Antp (show HOXA7 Proteins)-Ubx-AbdA-negative cells form a novel cardiac outflow component we call the outflow hanging structure, whereas the Antp (show HOXA7 Proteins)-expressing cells differentiate into wing heart precursors.
natural variation in a conserved trait-even-skipped (eve) expression at the cellular blastoderm stage of embryonic development in Drosophila melanogaster, was investigated.
Ubiquitous TER94 expression is "replaced" by expression in an eve pattern when Homie is deleted, and this effect is reversed when the PRE is also removed
Deletion of any individual enhancer reduced Yan occupancy at the other elements, impacting eve expression, cell fate specification, and cardiac function
Data strongly suggests that the eve-grn (show GRN Proteins) transcriptional code controls axon guidance, in part, by regulating the level of unc-5 expression.
even-skipped genes were misexpressed in pho mutant embryos
analysis of combinatorial activation and concentration-dependent repression of the Drosophila even skipped stripe 3+7 enhancer; Zld is required for activation; Kni and Hb are dedicated repressors that function by direct DNA binding
Nmo regulates a subset of Eve activities by stimulating Eve-mediated suppression of the odd-skipped (odd) repressor
The repressor activity of Even-skipped is highly conserved, and is sufficient to activate engrailed and to regulate both the spacing and stability of parasegment boundaries.
three distinct mechanisms are required for anterior repression of a single eve enhancer, each in a specific position
Isolation and expression pattern of a novel gene, Ami in Xenopus laevis.
MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked.
disturbance of reciprocal relationships between adipsin and leptin (show LEP Proteins) in obesity is associated with the development of insulin (show INS Proteins) resistance
TZDs (pioglitazone, rosiglitazone, and ciglitazone) slow tumor cell growth in vitro and in vivo with decreases in cell proliferation and increases in PPARg (show PPARG Proteins) and adipsin
The strong association of PLIN1 (show PLIN1 Proteins), CFD and ADIPOQ genes with adipogenesis prompted authors to study the influence the bone health status as evaluated by quantitative ultrasound (QUS) bone densitometer in a North Indian cohort. Overall, ADIPOQ (rs1501299 and rs3774261) and combined cluster of PLIN1 (show PLIN1 Proteins) rs2304796 and rs2304795) and CFD (rs1683563) demonstrated correlation.
our findings set up a novel mechanism for FABP4 (show FABP4 Proteins), adipsin and adiponectin through gut (show GUSB Proteins) microbiota mediating expression in gut (show GUSB Proteins) Paneth cells.
Overall adipsin levels among male asbestos industry workers were significantly higher than among control subjects.
Data indicate that a urinary protein, adipsin, was significantly increased in patients with preeclampsia.
Study demonstrates that T2DM patients with beta cell failure are deficient in adipsin.
Complement factor D (FD) is activated by its substrate through interactions outside the active site which lock the unbound native state into an ordered inactive conformation via the self-inhibitory loop in FD.
We demonstrate novel secretion of adipsin and ASP (show ASIP Proteins) by placental Hofbauer cells.
The present study identifies adipsin, one of the most abundant and specifically expressed adipose proteins, as a circulating factor linking fat cells and obesity to beta cell function.
Two sides of MGP (show MGP Proteins) null arterial disease: chondrogenic lesions dependent on transglutaminase 2 (show TGM2 Proteins) and elastin (show ELN Proteins) fragmentation associated with induction of adipsin.
local expression of adipsin has a reproductive effect at the feto-maternal interface and possibly plays a role in spontaneous abortion
MASP-1 converted pro-Df to the active form in vitro, although the activation mechanism of pro-Df by MASP-1 is still unclear. Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways.
Adipsin expression was not detected in any transfected clones of 3T3L1 cells exhibiting a complete blockage to differentiation.
Adipsin is a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor
Mesangial immune complex glomerulonephritis is due to Cfd deficiency.
In the process of spontaneous abortion, the innate immune system through adipsin and complement C3 (show C3 Proteins) appears to be influential.
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology.
, complementation group F
, group V
, group VI
, complement factor D (adipsin)
, serine protease ami
, complement factor D
, complement factor D (adipsin) like
, C3 convertase activator
, properdin factor D
, D component of complement (adipsin)
, complement factor D preproprotein
, endogenous vascular elastase
, 28 kDa adipocyte protein
, D component (adipsin) of complement