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anti-Human ERCC1 Antibodies:
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Chinese Hamster Monoclonal ERCC1 Primary Antibody for ICC, IF - ABIN269278
Al-Minawi, Saleh-Gohari, Helleday: The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. in Nucleic acids research 2008
Show all 15 Pubmed References
Human Monoclonal ERCC1 Primary Antibody for ICC, IF - ABIN2720418
Ma, Baruch, Shu, Yuan, Sun, Ma, Hoang, Fu, Min, Lan, Wang, Mull, He: Using protein microarray technology to screen anti-ERCC1 monoclonal antibodies for specificity and applications in pathology. in BMC biotechnology 2012
Show all 4 Pubmed References
Human Monoclonal ERCC1 Primary Antibody for WB - ABIN1882194
Hoeijmakers, van Duin, Westerveld, Yasui, Bootsma: Identification of DNA repair genes in the human genome. in Cold Spring Harbor symposia on quantitative biology 1987
Show all 3 Pubmed References
Human Monoclonal ERCC1 Primary Antibody for IP, WB - ABIN967531
Kenigsberg, Elliott, Cuello: Two distinct monoclonal antibodies raised against mouse beta nerve growth factor. Generation of bi-specific anti-nerve growth factor anti-horseradish peroxidase antibodies for use in a homogeneous enzyme immunoassay. in Journal of immunological methods 1991
Human Monoclonal ERCC1 Primary Antibody for ICC, IF - ABIN151044
Tentori, Muzi, Dorio, Dolci, Campolo, Vernole, Lacal, Praz, Graziani: MSH3 expression does not influence the sensitivity of colon cancer HCT116 cell line to oxaliplatin and poly(ADP-ribose) polymerase (PARP) inhibitor as monotherapy or in combination. in Cancer chemotherapy and pharmacology 2013
Human Polyclonal ERCC1 Primary Antibody for ELISA, WB - ABIN314230
Zhang, Liu, Li, Legerski: Double-strand breaks induce homologous recombinational repair of interstrand cross-links via cooperation of MSH2, ERCC1-XPF, REV3, and the Fanconi anemia pathway. in DNA repair 2007
in nasopharyngeal carcinoma patients, ERCC1 and BRCA1 may be a predictor of response to platinum-based chemotherapy and concurrent radiochemotherapy.
Relevant SNPs in DNA repair (ERCC1 and ERCC5 (show ERCC5 Antibodies)) and apoptosis (MDM2 (show MDM2 Antibodies) and TP53 (show TP53 Antibodies)) genes might influence the severity of radiation-related side-effects in HNSCC patients. Prospective clinical SNP-based validation studies are needed on these bases
these studies found that carriers of the T allele of ERCC1 rs11615, XPC (show XPC Antibodies) rs2228000 and rs50872, particularly in postmenopausal females, have an increased risk of breast cancer
Pretreatment ERCC1 expression status predicts tumor response and survival of patients with recurrent or metastatic uterine cervical cancer receiving platinum-based chemotherapy.
ERCC1 might be an effective predictor of response to FOLFIRINOX in metastatic pancreatic cancer
Both blood and tumor tissue MGMT (show MGMT Antibodies) and ERCC1 methylation were associated with cancer rectum.
Data suggest that genetic variants of XRCC4 (show XRCC4 Antibodies) and ERCC1 may independently or jointly affect survival in chemotherapy-treated gastric cancer (GCa (show NPR1 Antibodies)) patients by modulating the gene expression in the tumors.
Allelic variants in ERCC1 and ERCC2 are not associated with an increased risk of developing pre-senile cataract. The presence of Gln/Gln in XRCC1 in the pre-senile cataract group with regard to the group without cataract is associated with a major risk of developing pre-senile cataract.
ERCC1 polymorphism is associated with colorectal cancer.
We demonstrated an association between six previously published single nucleotide polymorphisms (rs15869 [ BRCA2 (show BRCA2 Antibodies)], rs1805389 [ LIG4 (show LIG4 Antibodies)], rs8079544 [ TP53 (show TP53 Antibodies)], rs25489 [ XRCC1 (show XRCC1 Antibodies)], rs1673041 [ POLD1 (show POLD1 Antibodies)], and rs11615 [ ERCC1]) and subsequent CNS tumors in survivors of childhood cancer treated by radiation therapy.
Dietary tryptophan restriction increased microbial diversity and made the gut (show GUSB Antibodies) microbiota composition of old Ercc1(-/Delta7) mice more similar to that of young WT mice.
ERCC1-XPF (show ERCC4 Antibodies) cooperates with CTCF (show CTCF Antibodies) and cohesin to facilitate the developmental silencing of imprinted genes and that persistent DNA damage triggers chromatin changes that affect gene expression programs associated with NER (show NR1H2 Antibodies) disorders.
we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b (show BUB1B Antibodies)(H/H) mice, which have a faulty mitotic checkpoint (show BUB3 Antibodies), and Ercc1(-/Delta7) mice, defective in nucleotide excision repair and inter-strand crosslink repair. we found that Bub1b (show BUB1B Antibodies)(H/H), but not Ercc1(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...
these results establish USP45 as a new regulator of XPF (show ERCC4 Antibodies)-ERCC1 crucial for efficient DNA repair
ERCC1 is critical for protecting chondrocytes from catabolic stress and is associated with the pathophysiology of osteoarthritis.
SLX4 (show BTBD12 Antibodies) is a tumor suppressor, which activates XPF (show ERCC4 Antibodies)-ERCC1 nuclease (show DCLRE1C Antibodies) specificity in DNA crosslink repair.
ERCC1 is essential for melanoma growth and resistance to cisplatin.
Smad4 (show SMAD4 Antibodies) loss-associated Snail (show SNAI1 Antibodies) reduction compromises Ercc1-mediated DNA repair, contributing to increased UV-induced skin carcinogenesis.
analysis of accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(delta/-) mouse
This study demonistrated that the ERCC1 deficiency-associated downregulation of the cholesterol biosynthesis pathway is at least in part due to lowered expression of its master transcription factor SREBF2 (show SREBF2 Antibodies)
ERCC1 and XPF (show ERCC4 Antibodies) protect short telomeres from homologous recombination.
These data support a model in which the interstrand crosslink repair-specific function of XPF-ERCC1 is dependent on recruitment, positioning and substrate recognition.
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
DNA excision repair protein ERCC-1
, excision repair 1
, excision repair cross-complementing 1
, excision repair protein
, excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)