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Human MCM3 Protein expressed in Wheat germ - ABIN1310549
Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011
High MCM3 expression is associated with bone metastasis and advanced human prostate cancer.
the decreased growth of osteosarcoma cells by MCM2 or MCM3 knockdown was reversed by DHX9 overexpression, indicating that MCM2 and MCM3 activity was DHX9-dependent.
reveal the Minichromosome Maintenance Complex to be a critical and directly regulated node within the miR (show MLXIP Proteins)-183 signaling network in MYCN (show MYCN Proteins)-amplified neuroblastoma (show ARHGEF16 Proteins) cells. Randomly selected MCMs 3 and 5 were experimentally confirmed as direct targets of miR (show MLXIP Proteins)-183.
The results of our preliminary study emphasize the need for future research on MCM-3 as a sensitive proliferation marker, providing an alternative to Ki-67 (show MKI67 Proteins), in cases of various major salivary gland epithelial tumors in children and adolescents.
These data establish new functions for KEAP1 within the nucleus and identify MCM3 as a novel substrate of the KEAP1-CUL3-RBX1 E3 ligase.
The aim of this study is to analyze the immunoexpression of Ki67 (show MKI67 Proteins), p53 (show TP53 Proteins), MCM3 and PCNA (show PCNA Proteins) markers in epithelial remnants of dental follicles of impacted teeth and to identify a possible correlation between the immunoexpression of these markers in dentigerous cysts and keratocystic odontogenic tumors.
High MCM-3 expression correlated with Cutaneous T-cell Lymphomas.
normal DNA replication and replication checkpoint activation is regulated through the novel phosphorylation of MCM3 by Chk1 (show CHEK1 Proteins)
Results show that in Glioma patients, MCM 2 (show MCM2 Proteins), MCM3 and MCM7 (show MCM7 Proteins) mRNA are up-regulated and correlated with poor outcome.
Of the total, the deregulation of several genes (CDK1 (show CDK1 Proteins), CDK2 (show CDK2 Proteins), CDK4 (show CDK4 Proteins), MCM2 (show MCM2 Proteins), MCM3, MCM4 (show MCM4 Proteins), EIF3a (show EIF6 Proteins) and RPN2 (show PSMD1 Proteins)) were potentially associated with disease development and progression.
Mcm3-deficient erythroblasts display aberrant DNA replication patterns and fail to complete maturation, causing lethal anemia.
interaction with GANP (show MCM3AP Proteins) DNA-primase is associated with a novel phosphatase component G5PR (show PPP2R3C Proteins)
Depletion of Orc2 and Mcm3 by siRNA leads to an inhibition of cell proliferation, an altered cell cycle distribution as well as to multinucleated cells with insufficiently organised microtubules.
analysis of carboxyl-terminal MCM3 phosphorylation sites and their motifs
These data reveal that CDK (show CDK4 Proteins)-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2-7 (show MCM2 Proteins) complex.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
, minichromosome maintenance 3
, minichromosome maintenance-PCR2
, MCM3 minichromosome maintenance deficient 3
, zygotic minichromosome maintenance protein 3
, DNA replication licensing factor MCM3
, DNA polymerase alpha holoenzyme-associated protein P1
, DNA replication factor MCM3
, RLF subunit beta
, cervical cancer proto-oncogene 5
, hRlf beta subunit
, minichromosome maintenance deficient 3
, replication licensing factor, beta subunit
, P1 homolog
, XRLF subunit beta
, maternal DNA replication licensing factor mcm3
, maternal minichromosome maintenance protein 3
, mini chromosome maintenance deficient