Catalog No. ABIN2725631
$956.40
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20 μg
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United States
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Quick Overview for MCM3 Protein (Myc-DYKDDDDK Tag) (ABIN2725631)
Target
See all MCM3 Proteins
MCM3
(Minichromosome Maintenance Complex Component 3 (MCM3))
Protein Type
Recombinant
Origin
Human
Source
HEK-293 Cells
Application
Antibody Production (AbP), Standard (STD)
Purity
> 80 % as determined by SDS-PAGE and Coomassie blue staining
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Purification tag / Conjugate
- This MCM3 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human MCM3 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Minichromosome Maintenance Complex Component 3 (MCM3) (AA 699-808) protein (GST tag)
MCM3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))
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Alternative Name
- Mcm3
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Background
- The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
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Molecular Weight
- 90.8 kDa
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NCBI Accession
- NP_002379
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Pathways
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
Target
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