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Human MCM6 Protein expressed in Wheat germ - ABIN1310559
Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011
Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization.
MCM6 is a highly reproducible marker of poor prognosis in endometrial cancer
genetic association studies in population in Western Europe: Data confirm an SNP in MCM6 (rs4988235) is predictive of milk consumption; lack of association of genetically predicted milk consumption with prevention of osteoporosis, ischemic heart disease, or type 2 diabetes suggests few beneficial effects of milk consumption but is more consistent with milk promoting adiposity/overweight.
MCM2-MCM6 complex is required for CHK2 chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.
This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded.
knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei.
Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma
Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4
Report presence of homozygous--13910CC genetic variant in the MCM-6 gene upstream from the lactase gene in lactose intolerant patients treated with lactose-restricted diet.
Mcm2-7 loads onto origins during initiation as a double hexamer, yet does not act as a double-stranded DNA pump during elongation.
Results indicate that the interaction between hCdt1 and hMcm6 through their interacting domains is key for hCdt1 in facilitating the MCM hetero-hexamer to load onto chromatin for replication licensing.
The subtype and MCM6 protein expression in craniopharyngiomas are related to the prognosis of tumor.
the molecular mechanism of Mcm2-7 chromatin loading and prereplicative complex assembly.
The numbers of the three genotypic combinations reveal that the percentage of this population that is genetically lactose intolerant is 8.23% and that the allele frequencies found are consistent with the expected Mendelian distribution.
Data show that cells subjected to chronic hypoxia the replicative restart was inhibited along with numerous replication factors including MCM6 and RPA, and cells reoxygenated after acute hypoxia underwent rapid p53-dependent apoptosis.
It was found that the MCM6 label index (LI) was significantly higher in adamantine epithelioma than squamous papillary tumor, and in both primary tumor subtypes the LIs of tumors with recurrence were higher than those without recurrence.
role of subunits in dna helicase activity
Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
Accumulation and dynamics of Mcm6 are described during oogenesis and the first embryonic cell cycle.
DNA binding and helicase activities of Mcm4/6/7 are significantly stimulated by Cdt1
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
, female sterile(1)K1214
, minichromosome maintenance 6
, DNA replication licensing factor MCM6
, MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
, minichromosome maintenance deficient (mis5, S. pombe) 6
, minichromosome maintenance deficient 6 homolog
, intestinal DNA replication protein
, mini chromosome maintenance deficient 6
, minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
, maternal DNA replication licensing factor mcm6
, maternal minichromosome maintenance protein 6
, mis5 homolog