Browse our Minichromosome Maintenance Complex Component 7 Proteins (MCM7)

Full name:: Minichromosome Maintenance Complex Component 7 Proteins (MCM7)

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Synonyms:: AI747533, anon-EST:Liang-1.66, cdc47, cdc47-2, CG4978, chunp6911, clone 1.66, Dmel\\CG4978, DmeMCM7, DmMCM7, mCDC47, MCM2, McM7, Mcmd7, Mcp-PCR1, nyz175, P1.1-MCM3, P1CDC47, P85MCM, PCR1, PNAS146, sr:nyz175, xmcm7

list all proteins	Gene Name	GeneID	UniProt
Human MCM7	MCM7	4176	P33993
Rat MCM7	MCM7	288532
Mouse MCM7	MCM7	17220	Q61881
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Top referenced Minichromosome Maintenance Complex Component 7 Proteins

Human MCM7 Protein expressed in Wheat germ - ABIN1310563 : Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011 (PubMed)

More Proteins for Minichromosome Maintenance Complex Component 7 Interaction Partners

Human Minichromosome Maintenance Complex Component 7 (MCM7) interaction partners

CDT1 (show CDT1 Proteins), MCM7, and NUDT1 (show NUDT1 Proteins) were shown to be up-regulated in hepatocellular carcinoma tissues and provide a more accurate diagnosis than alpha-fetal protein alone.
High expression of MCM-7 was reduced in BVP-treated cancer cells.
Data indicate that RACK1 (show GNB2L1 Proteins) increases interactions between Akt (show AKT1 Proteins) and MCM7 and promotes Akt (show AKT1 Proteins)-dependent MCM7 phosphorylation, which in turn increases MCM7 binding to chromatin and miniature chromosome maintenance (MCM) complex formation.
our findings suggested that MCM7 promoted tumor cell proliferation, colony formation and migration of ESCC cells via activating AKT1 (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway
Results proved that MCM7 proliferative index is a better method for identifying patients with risk of recurrence in patients surgically resected for meningiomas compared with the traditional methods used in the current clinical practice.
MCM7-cyclin D1 (show CCND1 Proteins) pathway may participate in cancer progression.
The MCM7 directly binds to the centrosomal linker protein (show LAT Proteins) Cep68 in vitro and complexes with Cep68 and VHL (show VHL Proteins) in vivo.
The results clearly demonstrate 7q21-22 amplification, MCM7, and its intronic miR (show MLXIP Proteins)-25 are the major molecular switches involved in the complex oncogenic circuits of gastric cancer.
High MCM7 expression is associated with non-small cell lung cancer.
MCM4 (show MCM4 Proteins) and MCM7 expression is significantly correlated with Ki-67 (show MKI67 Proteins), Bmi1 (show BMI1 Proteins), and cyclin E (show CCNE1 Proteins) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.

Mouse (Murine) Minichromosome Maintenance Complex Component 7 (MCM7) interaction partners

Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
cyclin D1 (show CCND1 Proteins)/CDK4 (show CDK4 Proteins) complexes play a direct role in altering an inhibitory RB.MCM7 complex possibly allowing for setting of the origin in preparation for DNA replication
MCM7 may be a highly informative biomarker for cervical cancer.
Substrate preference and helicase actions of mouse MCM4/6/7 helicase complexes.
Accumulation and dynamics of Mcm7 are described during oogenesis and the first embryonic cell cycle.
cellular DNA replication factor (show CDT1 Proteins) MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by green tea catechins
DNA binding and helicase activities of Mcm4 (show MCM4 Proteins)/6/7 are significantly stimulated by Cdt1 (show CDT1 Proteins)

Xenopus laevis Minichromosome Maintenance Complex Component 7 (MCM7) interaction partners

Mcm2-7 (show MCM2 Proteins) associate with Cdc45 (show CDC45 Proteins) and GINS to form a relatively stable CMG (show CASK Proteins) (Cdc45 (show CDC45 Proteins)-MCM-GINS) complex.

Minichromosome Maintenance Complex Component 7 (MCM7) Protein Profile

Protein Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with Minichromosome Maintenance Complex Component 7 (MCM7)

minichromosome maintenance complex component 7 (MCM7)
mini-chromosome maintenance complex protein 7 (MCM7)
mini-chromosome maintenance complex protein 7 (CDC47)
minichromosome maintenance complex component 7 (Mcm7)
minichromosome maintenance complex component 2 (MCM2)
minichromosome maintenance complex component 7 (mcm7)
minichromosome maintenance complex component 7 L homeolog (mcm7.L)
Minichromosome maintenance 7 (Mcm7)
minichromosome maintenance complex component 7 S homeolog (mcm7.S)
MCM complex subunit Mcm7 (mcm7)

AI747533 protein
anon-EST:Liang-1.66 protein
cdc47 protein
cdc47-2 protein
CG4978 protein
chunp6911 protein
clone 1.66 protein
Dmel\\CG4978 protein
DmeMCM7 protein
DmMCM7 protein
mCDC47 protein
MCM2 protein
McM7 protein
Mcmd7 protein
Mcp-PCR1 protein
nyz175 protein
P1.1-MCM3 protein
P1CDC47 protein
P85MCM protein
PCR1 protein
PNAS146 protein
sr:nyz175 protein
xmcm7 protein

Protein level used designations for MCM7

, , , , , , , , , , , , , , , , , , , , , , , , , , , CDC47 homolog DNA replication licensing factor MCM7 homolog of S. cerevisiae Cdc47 minichromosome maintenance deficient 7 hypothetical protein minichromosome maintenance protein 7 MCM7 minichromosome maintenance deficient 7 minichromosome maintenance complex component 7 DNA replication licensing factor MCM7-like minichromosome maintenance complex component 2 mini chromosome maintenance deficient 7 CDC47 homolog B CDC47-2p DNA replication licensing factor mcm7-B minichromosome maintenance protein 7-B xMCM7-B CG4978-PA Mcm7-PA minichromosome maintenance 7 minichromosome maintenance-PCR1 CDC47 homolog A CDC47p DNA replication licensing factor mcm7-A XMCM7 minichromosome maintenance protein 7-A p90 xMCM7-A Minichromosome maintenance protein 7

GENE ID	SPECIES
4176	Homo sapiens
852501	Saccharomyces cerevisiae S288c
3645780	Candida albicans SC5314
288532	Rattus norvegicus
472460	Pan troglodytes
479737	Canis lupus familiaris
539924	Bos taurus
710766	Macaca mulatta
100401193	Callithrix jacchus
100442048	Pongo abelii
100481582	Ailuropoda melanoleuca
17220	Mus musculus
192333	Danio rerio
380414	Xenopus laevis
39014	Drosophila melanogaster
397852	Xenopus laevis
100719227	Cavia porcellus
2540630	Schizosaccharomyces pombe 972h-

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Show all Minichromosome Maintenance Complex Component 7 Proteins (MCM7) with Pubmed References