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anti-Mouse (Murine) MUS81 Antibodies:
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Human Monoclonal MUS81 Primary Antibody for FACS, ICC - ABIN108570
Nomura, Adachi, Koyama: Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. in Genes to cells : devoted to molecular & cellular mechanisms 2007
Show all 11 Pubmed References
Human Monoclonal MUS81 Primary Antibody for CyTOF, FACS - ABIN151532
Rodrigue, Coulombe, Jacquet, Gagné, Roques, Gobeil, Poirier, Masson: The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy. in Journal of cell science 2013
Show all 2 Pubmed References
Human Polyclonal MUS81 Primary Antibody for ICC, IF - ABIN442031
Sun, Brieño-Enríquez, Cornelius, Modzelewski, Maley, Campbell-Peterson, Holloway, Cohen: FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. in Chromosoma 2016
spontaneous mitotic crossovers that occur when FANCM is missing are dependent on MUS312 and either MUS81 or SLX1.
did not find any role for MUS81-MMS4 in meiotic crossing over
SEND1 has at most a minor role in resolution of the Holliday junction but acts as an essential backup to MUS81 for resolution of toxic replication structures to ensure genome stability and to maintain telomere integrity.
Data show that DNA polymerase zeta catalytic subunit REV3 (show REV3L Antibodies) cooperates with ATP-dependent DNA helicase RECQ4A and e ndonuclease MUS81 to repair DNA interstrand cross links.
RECQ4A and MUS81 define RAD5A-independent pathways of DNA repair. RECQ4A and MUS81 act in parallel pathways presumably to resolve replication-associated DNA intermediates.
The role of AtMUS81 in meiotic and mitotic recombination.
AtMUS81 is involved in a secondary subset of meiotic crossovers that are interference insensitive.
The role of MUS81 in the reproduction and growth of A. thaliana, via its expression and metabolism during meiosis, is reported.
Both MUS81-EME1 endonuclease complexes are involved in DNA recombination and repair processes in Arabidopsis.
this study shows that immune rejection of prostate cancer cells relies on Mus81 and STING
Our study highlights the importance of the cooperation between Rad54 (show RAD54L Antibodies) and Mus81 for mediating DNA DSB repair and restraining chromosome missegregation.
Mus81 knockdown improves the chemosensitivity of HCC (show FAM126A Antibodies) cells by inducing S-phase arrest and promoting apoptosis through CHK1 (show CHEK1 Antibodies) pathway, suggesting Mus81 as a novel therapeutic target for HCC (show FAM126A Antibodies).
Using mice deficient in both Mus81 and the FA pathway protein FancC (show FANCC Antibodies), we show both proteins cooperate in parallel pathways, as concomitant loss of FancC (show FANCC Antibodies) and Mus81 triggered cell-type-specific proliferation arrest, apoptosis and DNA damage accumulation in utero.
Data indicate that SLX1 and MUS81-EME1 nucleases act together to resolve Holliday junctions (HJs) in a manner that requires tethering to SLX4 (show BTBD12 Antibodies).
FBH1 (show FBXO18 Antibodies) helicase (show DNA2 Antibodies) activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks.
data indicate that an important role for Chk2 (show CHEK2 Antibodies) is maintaining lymphocyte development and that dual inactivation of Chk2 (show CHEK2 Antibodies) and Mus81 remarkably inhibits cancer
studies demonstrate a critical role for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression
Mus81 acts at a late step in the repair of cross-link-induced lesions
Mus81-Eme1- and Rad54 (show RAD54L Antibodies)-mediated homologous recombination are involved in the same DNA replication-dependent interstrand crosslinks repair pathway
The results showed that MUS81 modulates MCM2 (show MCM2 Antibodies) levels as well as homologous recombination (HR) activity. Moreover, downregulation of MUS81 increased the sensitivity of epithelial ovarian cancer (EOC)cells to olaparib by inducing S phase arrest and promoting apoptosis through activation of MCM2 (show MCM2 Antibodies). MUS81 may be a potential novel therapeutic target for EOC.
Mus81 knockdown improves the chemosensitivity of colon cancer cells by inducing S phase arrest and promoting apoptosis through activating CHK1 (show CHEK1 Antibodies) pathway
Low EZH2 (show EZH2 Antibodies) or MUS81 expression levels predict chemoresistance.
RECQ5 removes RAD51 filaments stabilizing stalled replication forks at common fragile sites and hence facilitates CFS cleavage by MUS81-EME1.
The mitotic DNA synthesis is RAD52 (show RAD52 Antibodies) dependent, and RAD52 (show RAD52 Antibodies) is required for the timely recruitment of MUS81 and POLD3 (show POLD3 Antibodies) to common fragile sites in early mitosis.
Data suggest that dimeric GEN1 binds with high affinity/selectivity to Holliday junctions, introducing two symmetrical hydrolytic cleavages of phosphodiester backbone; at present, less is known about SLX1-SLX4-MUS81-EME1 resolving enzyme complex. (GEN1 = Holliday junction 5' flap endonuclease; SLX = structure-specific endonuclease subunit; MUS81 = MUS81 endonuclease; EME1 = essential meiotic endonuclease 1) [REVIEW]
down-regulation of MUS81 expression in ovarian cancer cells inhibited cell proliferation and colony formation ability, and influenced cell cycle progression
SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).
Mus81 sumoylation is important for normal mitotic chromosome congression.
Data suggest that the ATM (show ATM Antibodies)/Chk2 (show CHEK2 Antibodies) may promote the repair of DNA damage caused by cisplatin by sustaining methyl methanesulfonate and ultraviolet-sensitive gene clone 81, and the double-strand breaks generated by methyl methanesulfonate and ultraviolet-sensitive gene clone 81 may activate the ATM (show ATM Antibodies)/Chk2 (show CHEK2 Antibodies) pathway.
Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
, crossover junction endonuclease MUS81
, MUS81 endonuclease homolog (S. cerevisiae)
, MUS81 endonuclease homolog
, MUS81 protein
, crossover junction endonuclease MUS81-like
, SLX3 structure-specific endonuclease subunit homolog
, hypothetical protein