MUS81 antibody (AA 1-350)

Catalog No. ABIN6144202

Product Details anti-MUS81 Antibody

Target: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Binding Specificity: AA 1-350

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUS81 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: MAAPVRLGRK RPLPACPNPL FVRWLTEWRD EATRSRRRTR FVFQKALRSL RRYPLPLRSG KEAKILQHFG DGLCRMLDER LQRHRTSGGD HAPDSPSGEN SPAPQGRLAE VQDSSMPVPA QPKAGGSGSY WPARHSGARV ILLVLYREHL NPNGHHFLTK EELLQRCAQK SPRVAPGSAR PWPALRSLLH RNLVLRTHQP ARYSLTPEGL ELAQKLAESE GLSLLNVGIG PKEPPGEETA VPGAASAELA SEAGVQQQPL ELRPGEYRVL LCVDIGETRG GGHRPELLRE LQRLHVTHTV RKLHVGDFVW VAQETNPRDP ANPGELVLDH IVERKRLDDL CSSIIDGRFR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human MUS81 (NP_079404.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MUS81

Target: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Alternative Name: MUS81 (MUS81 Products)

Synonyms: CG3026 antibody, Dmel\\CG3026 antibody, EG:BACR7A4.16 antibody, MUS81 antibody, GB15332 antibody, ARABIDOPSIS THALIANA MMS AND UV SENSITIVE 81 antibody, ATMUS81 antibody, F6I18.220 antibody, F6I18_220 antibody, MMS AND UV SENSITIVE 81 antibody, SLX3 antibody, slx3 antibody, 1200008A18Rik antibody, AI182501 antibody, AW045863 antibody, wu:fc26g01 antibody, zgc:66489 antibody, zgc:91801 antibody, CG3026 gene product from transcript CG3026-RA antibody, MUS81 structure-specific endonuclease subunit antibody, crossover junction endonuclease MUS81 antibody, Restriction endonuclease, type II-like superfamily protein antibody, Mus81p antibody, Holliday junction resolvase subunit Mus81 antibody, MUS81 protein antibody, hypothetical protein antibody, mus81 antibody, MUS81 antibody, LOC725951 antibody, Mus81 antibody, CAALFM_C600540WA antibody

Background: This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.,MUS81,SLX3,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Tumor suppressors,MUS81

Molecular Weight: 61 kDa

Gene ID: 80198

UniProt: Q96NY9

Pathways: DNA Damage Repair