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NEIL1 and homotetrameric mtSSB form a larger ternary complex in presence of DNA, however, the tetrameric form of mtSSB gets disrupted by NEIL1 in the absence of DNA as revealed by the formation of a smaller NEIL1-mtSSBmonomer complex.
The major role of acetylable Lys (show LYZ Proteins) residues in NEIL1 is to stabilize the formation of chromatin-bound repair complexes which protect cells from oxidative stress.
The level of OGG1 (show OGG1 Proteins) expression was significantly reduced in bipolar patients compared to healthy individuals, whereas the two groups exhibited similar levels of NEIL1 expression.
Data indicate that DNA glycosylases MYH (show MUTYH Proteins), UNG2 (show CCNO Proteins), MPG (show MPG Proteins), NTH1, NEIL1, 2 and 3 on nascent DNA.
identified the c-Jun N-terminal kinase 1 (JNK1 (show MAPK8 Proteins)) as the kinase involved in the phosphorylation of NEIL1
NEIL1 (rs5745908) is associated with Behcet's disease. The genetic association in NEIL1 is a predicted splice donor variant that may introduce a deleterious intron retention and result in a noncoding transcript variant.
cellular NEIL1 is regulated by the UPP (show UPP1 Proteins) mediated by the E3 ubiquitin ligases Mule (show HUWE1 Proteins) and TRIM26 (show TRIM26 Proteins), which plays a vital role in co-ordinating the cellular response to DNA damage.
Nei (show PMCH Proteins) Like DNA Glycosylase 1 (NEIL1) as a likely candidate gene due to its crucial role in B-cell activation (show BLNK Proteins) and terminal differentiation.
The abnormal expressions of NEIL1, NEIL2 (show NEIL2 Proteins), and NEIL3 (show NEIL3 Proteins) are involved in cancer through their association with the somatic mutation load.
NEIL1 and NEIL2 (show NEIL2 Proteins) cooperate with TDG (show TDG Proteins) during base excision: TDG (show TDG Proteins) occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG (show TDG Proteins)-substrate turnover.
Loss of Neil1 expression is associated with hepatocellular carcinoma.
Collectively the data suggest that NEIL1-initiated repair of a subset of ROS (show ROS1 Proteins)-induced DNA base lesions may be insufficient to prevent the initiation of inflammatory pathways during chronic UV exposure in mouse skin.
Rad9 (show RAD9A Proteins) regulates base excision repair by controlling Neil1 protein stability in mouse embryonic stem cells.
Hypersensitivity to H2O2 caused by NEIL1 knockdown was more significant in S phase than in G1 phase, suggesting that NEIL1 has an important role during S phase.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (show OGG1 Proteins), Neil1, Mutyh (show MUTYH Proteins) and Xrcc1 (show XRCC1 Proteins) in the brain of adult offspring.
one role for Neil3 (show NEIL3 Proteins) and NEIL1 is to repair DNA base damages in telomeres in vivo and that Neil3 (show NEIL3 Proteins) and Neil1 may function in quadruplex-mediated cellular events, such as gene regulation via removal of damaged bases from quadruplex DNA.
binds to the BRCT domain of PARP-1 (show PARP1 Proteins)
Neil1 contributes to germline and somatic Huntington's disease CAG repeat (show CELF3 Proteins) expansion.
Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice.
NEIL1 deficiency results in an increased susceptibility to obesity and related complications potentially by lowering the threshold for tolerance of cellular oxidative stress in neil1(-/-) mice.
This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene.
endonuclease VIII-like 1
, DNA glycosylase/AP lyase Neil1
, DNA-(apurinic or apyrimidinic site) lyase Neil1
, endonuclease 8-like 1
, endonuclease VIII
, nei homolog 1
, nei-like protein 1