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This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.
DNA-directed DNA polymerase eta
, DNA polymerase eta
, polymerase (DNA directed), eta
, DNA polymerase eta-like
, polymerase eta
, RAD30 homolog A
, xeroderma pigmentosum variant type protein
, polymerase (DNA directed), eta (RAD 30 related)
, xeroderma pigmentosum variant type protein homolog