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Human Monoclonal NKX6-1 Primary Antibody for BI, IF - ABIN2689864
Donelan, Koya, Li, Yang: Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells. in The Journal of biological chemistry 2010
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Human Polyclonal NKX6-1 Primary Antibody for ICC, IF - ABIN4340068
Theofilopoulos, Wang, Kitambi, Sacchetti, Sousa, Bodin, Kirk, Saltó, Gustafsson, Toledo, Karu, Gustafsson, Steffensen, Ernfors, Sjövall, Griffiths, Arenas: Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. in Nature chemical biology 2013
Show all 4 Pubmed References
Human Polyclonal NKX6-1 Primary Antibody for ICC, IF - ABIN4340070
Bader, Migliorini, Gegg, Moruzzi, Gerdes, Roscioni, Bakhti, Brandl, Irmler, Beckers, Aichler, Feuchtinger, Leitzinger, Zischka, Wang-Sattler, Jastroch, Tschöp, Machicao, Staiger, Häring, Chmelova et al.: Identification of proliferative and mature β-cells in the islets of Langerhans. ... in Nature 2016
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Data demonstrated that patients with NKX6.1 methylation presented poorer 5-year overall survival (P = 0.0167) and disease-free survival (P = 0.0083) than patients without NKX6.1 methylation after receiving adjuvant chemotherapy.
Data indicate the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ pancreatic progenitors (PPs).
Efficiency of differentiation of Induced pluripotent stem cells to insulin producing cells can be increased by concurrent expression of PDX1 and NKX6.1 during progenitor cells maturation.
NKX6.1 directly enhances the mRNA level of E-cadherin by recruiting BAF155 coactivator and represses that of vimentin and N-cadherin by recruiting RBBP7 (retinoblastoma binding protein 7) corepressor.
NKX6.1 is a factor for IL-6-regulated growth and tumor formation in basal-like breast cancer.
a significant relationship was observed between NKX6.1 and EMT marker expression levels, and NKX6.1 knockdown inhibited cell invasion, and overexpression of NKX6.1 promotes cell proliferation in vitro.
study evaluated the potential use of NKX6-1 as a diagnostic marker for well-differentiated neuroendocrine tumors
NKX6-1 reveals wide variations in methylation levels in normal control samples of cervical adenocarcinomas.
Mice transplanted with NKX6.1-low cells remained hyperglycemic throughout the 5-month post-transplant period whereas diabetes was reversed in NKX6.1-high recipients within 3 months.
MAFA, MAFB, NKX6.1, and PDX1 activity provides a gauge of islet beta cell function, with loss of MAFA (and/or MAFB) representing an early indicator of beta cell inactivity
Smooth muscle cells expressing nestin and Nkx6.1 are the main cell population derived from culturing human spinal cord cells in adherent conditions with serum.
Data suggest that NKX6.1 activates immature pancreatic markers but not pancreatic hormone gene expression in human liver cells, and suggest a potential role for NKX6.1 in promoting PDX-1 reprogrammed maturation along a beta-cell-like lineage.
identified an NKX6.1 recognition sequence in the distal region of the HNF1alpha promoter and demonstrated specific binding of NKX6.1 in beta cells
Nkx6.1 is a bifunctional transcription factor that serves to maintain the specific expression of its own gene during beta-cell differentiation while simultaneously effecting broader gene repression events
overexpression of Nkx6.1 in islets caused an increase in the level of [(3)H]thymidine incorporation that was twice the control level, along with complete retention of glucose-stimulated insulin secretion
Alterations of gastric NKX6.1 expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia.
nkx6.1 regulates the alpha- and beta-cell formation in zebrafish by acting on the stem cells in the Islets of Langerhans.
In zebrafish, Nkx6.1 is expressed in early-born primary and later-born secondary motoneurons
Study shows that zebrafish primary motoneurons express two related transcription factors Nkx6.1 and Nkx6.2; in their absence, the CaP motoneuron subtype develops normally, whereas the MiP motoneuron subtype develops a interneuron-like morphology.
The results suggest that Nkx6.1 is involved in mid-hindbrain formation in Xenopus embryos, likely by modulating wnt1 expression.
Nkx6.1 and Nkx6.2 share overlapping expression domains in the ventral neural tube at neurula stages and later in the ventral part of developing hindbrain and spinal cord. Nkx6.3 is detected in the non-neural ectoderm.
our data reveal a novel mechanism of Notch1 transcriptional regulation in the ventral spinal cord by Nkx6.1 via its binding with Notch1 enhancer CR2 during embryonic development.
Nkx6.1 plays a vital role in astrocyte specification and differentiation in the ventral spinal cord.
Over time, Nkx6.1-deficient beta cells acquired molecular characteristics of delta cells, revealing a molecular link between impaired beta cell functional properties and loss of cell identity.
Our findings establish Nkx6.1 as a beta cell programming factor and demonstrate that repression of alternative lineage programs is a fundamental principle by which beta cells are specified and maintained.
Data found direct binding of RBP-jkappa to the Nkx6.1 proximal promoter.
Results demonstrate that sustained Nkx6.1 overexpression in vivo does not stimulate beta-cell proliferation, expand beta-cell mass, or improve glucose metabolism in either normal or beta-cell-depleted pancreata.
Nkx6 genes pattern the frog neural plate and Nkx6.1 is necessary for motoneuron axon projection.
Data show a longitudinal domain positive for both Nkx6.1 and Nkx6.2 that is medial to the Pou4f1-positive red nucleus. This domain could correspond to part of the reticular formation, which extends from the diencephalon and the mesencephalon.
Ependymal cells in adult spinal cord are derived from Nkx6.1+ ventral neural progenitor cells. Nkx6.1+ ependymal cells in adult mouse spinal cords may retain the proliferative property of neural stem cells.
Results demonstrate a requirement for Nkx6.1 in the development of postmitotic motoneurons, and suggest a cell-autonomous function in the control of branchio-motoneuron migration.
Nkx6.1 homeodomain neural progenitor gene is specifically expressed in the ventral neural tube, and its activity is required for motoneuron generation in the spinal cord.
Nkx6.1 is regulated by Nkx6.2; Nkx6.1 has distinct domains in the pancreas.
distinct requirements for Nkx6.1 and Nkx6.2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities
Nkx6 proteins, a set of Hox-regulated homeodomain transcription factors, are expressed by motor pools soon after motor neurons leave the cell cycle, before the formation of muscle nerve side branches in the limb of mice.
confocal analysis identifies an abundant triple-positive (Ptf1a(+)/Nkx6.1(+)/Pdx1(+)) putative early multipotent pancreatic progenitor cell that marks the e9.5 dorsal pancreas and e10.5 ventral pancreas.
Data show that subtype-restricted progenitors from the Nkx6.1+ region are present in the ventral spinal cord, although at a lower frequency than expected.
The homeodomain transcription factor Nkx6-1 controls the proper development of the red nucleus and of the oculomotor and trochlear nucleus neurons.
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004)
NK6 transcription factor related, locus 1
, NK6 homeobox 1
, NK homeo box, family 6, member A
, NK homeobox, family 6, A
, NK6 transcription factor homolog A
, homeobox protein NK-6 homolog A
, homeobox protein Nkx-6.1
, NK6 transcription factor related locus 1
, Drosophila NK transcription factor related, gene family 6, locus 1
, homeodomain transcription factor Nkx6.1