EGF Proteins

This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

Latest Publications for our EGF Proteins

Khan, Park, Fischer, Dong, Lungjangwa, Jimenez, Casalena, Chew, Dietmann, Auld, Jaenisch, Theunissen: "Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening." in: Cell reports, Vol. 35, Issue 11, pp. 109233, (2022) (PubMed).

Dong, Beltcheva, Gontarz, Zhang, Popli, Fischer, Khan, Park, Yoon, Xing, Kommagani, Wang, Solnica-Krezel, Theunissen: "Derivation of trophoblast stem cells from naïve human pluripotent stem cells." in: eLife, Vol. 9, (2021) (PubMed).

Qiao, Qian, Wang, Zhao, Ma, Wang, Zhang, Liu: "PD173074 blocks G1/S transition via CUL3-mediated ubiquitin protease in HepG2 and Hep3B cells." in: PLoS ONE, Vol. 15, Issue 6, pp. e0234708, (2020) (PubMed).

Chen, Zhang, Chang, Yang, Wang, Fu, Wei, Chen, Tan, Huang, Sun, Ni, Yang, Wang: "A bioenergetic shift is required for spermatogonial differentiation." in: Cell discovery, Vol. 6, pp. 56, (2020) (PubMed).

Wang, Hao, Yu, Huang, Pan, Zhao: "A Wearable and Deformable Graphene-Based Affinity Nanosensor for Monitoring of Cytokines in Biofluids." in: Nanomaterials (Basel, Switzerland), Vol. 10, Issue 8, (2020) (PubMed).

Hao, Pan, Huang, Wang, Zhao: "Sensitive detection of lung cancer biomarkers using an aptameric graphene-based nanosensor with enhanced stability." in: Biomedical microdevices, Vol. 21, Issue 3, pp. 65, (2019) (PubMed).

Minkoff, Blatz, Choudhury, Benjamin, Shohet, Sussman: "Plasma-Generated OH Radical Production for Analyzing Three-Dimensional Structure in Protein Therapeutics." in: Scientific reports, Vol. 7, Issue 1, pp. 12946, (2019) (PubMed).

Ye, Ge, Zhang, Cheng, Zhang, He, Wang, Lin, Yang, Liu, Zhao, Deng: "Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds." in: Cell research, Vol. 26, Issue 1, pp. 34-45, (2016) (PubMed).

Wang, Qian, Li, Pan, Njunge, Dong, Yang: "Evaluation of emulsion electrospun polycaprolactone/hyaluronan/epidermal growth factor nanofibrous scaffolds for wound healing." in: Journal of biomaterials applications, (2015) (PubMed).

Zhou, Zhang, Jin, Chen, Wu, Li, Yue, Luo, Wang: "Prokaryotic expression and refolding of EGFR extracellular domain and generation of phage display human scFv against EGFR." in: Biomedicine & pharmacotherapy, Vol. 67, Issue 8, pp. 737-43, (2013) (PubMed).

Aliases for EGF Proteins

epidermal growth factor (EGF) Proteins
epidermal growth factor (egf) Proteins
pro-epidermal growth factor (CpipJ_CPIJ020278) Proteins
epidermal growth factor (Egf) Proteins
AI790464 Proteins
CEGF Proteins
HOMG4 Proteins
URG Proteins

EGF Proteins

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Latest Publications for our EGF Proteins

Aliases for EGF Proteins

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