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Membrane-proximal domains ENTH of epsin domain can form a stable hexameric core in presence of phosphatidylinositol 4,5-bisphosphate (PIP2).
Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1.
intrinsically disordered domains are highly potent drivers of membrane curvature
Epsins are required for Dishevelled stability and Wnt signalling activation in colon cancer development.
AP-2 and epsin-1 are both required to promote efficient internalization of activated PAR1 and recognize discrete receptor sorting signals
An epsin 1 helix is inserted into one leaflet of the lipid bilayer, inducing curvature; on lipid monolayers epsin alone is sufficient to facilitate the formation of clathrin-coated invaginations
Together, these data provide evidence that CHIP functions to ubiquitylate the endocytic protein Epsin.
epsin 1 promotes endocytosis of the ubiquitinated EGF receptor
Results show that epsin 1, an endocytic adapter protein, regulates mitotic membrane morphology and spindle integrity in HeLa cells.
epsins 1 and 2 have a critical role in the temporal and spatial regulation of VEGFR3 abundance and signaling in collecting lymphatic trunks during lymphatic valve formation
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits.
Epsins function specifically to downregulate VEGFR2 by mediating activated VEGFR2 internalization and degradation and that genetic reduction of VEGFR2 level protects against excessive angiogenesis caused by epsin loss.
Data indicate a Cbl/p85/epsin-1 pathway in erythropoietin receptor (EpoR) endocytosis.
Loss of epsins 1 and 2 impaired endocytosis and degradation of VEGFR2, resulting in excessive VEGF signaling and compromised tumor vascular function.
epsin is an accessory protein linking ENaC to the clathrin-based endocytic machinery thereby regulating the activity of this ion channel at the cell surface
epsin has a role as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling in mammals
The protein encoded by this gene binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
EH domain-binding mitotic phosphoprotein
, EPS-15-interacting protein 1
, intersectin-EH-binding protein 1
, epsin 1
, LOW QUALITY PROTEIN: epsin-1