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Human Polyclonal ERBB2IP Primary Antibody for ICC, IF - ABIN4309327
Li, Zhou, Li, Wu, Liu, Zhao, Jia, Sun: Inhibition of Neddylation Modification Sensitizes Pancreatic Cancer Cells to Gemcitabine. in Neoplasia (New York, N.Y.) 2017
Our data uncovered an important role of Erbin in regulating hepatocellular carcinoma (HCC (show FAM126A Antibodies)) tumorigenesis through inactivating ERalpha (show ESR1 Antibodies)-mediated tumor-suppressive signaling, suggesting a new strategy for tamoxifen therapy in HCC (show FAM126A Antibodies) by targeting Erbin/ERalpha (show ESR1 Antibodies) signaling axis.
STAT3 (show STAT3 Antibodies) activation promotes ERBIN expression and negatively regulates TGF-beta (show TGFB1 Antibodies) activity by the formation of a STAT3 (show STAT3 Antibodies)-ERBIN-SMAD2 (show SMAD2 Antibodies)/3 complex.
Erbin loss accelerates cell cycle though down-regulating p21 (show CDKN1A Antibodies) and p27 (show PAK2 Antibodies) expression. Erbin is a novel negative modulator of Akt1 (show AKT1 Antibodies)-Skp2-p27 (show PAK2 Antibodies) signaling pathway.
Erbin promotes tumourigenesis and tumour growth in colorectal cancer by stabilizing epidermal growth factor receptor (show EGFR Antibodies)
Erbin is an ErbB2 (show ERBB2 Antibodies) regulator for breast tumor formation and progression
analysis of the C-terminal ligand specificity of the erbin PDZ domain (show INADL Antibodies)
Data suggest that Erbin can interact with Sema4C (show SEMA4C Antibodies), and co-expression of Erbin blocks the process of Sema4C (show SEMA4C Antibodies)-induced epithelial-mesenchymal transition.
Data reveal that Erbin is a negative regulator of AKT (show AKT1 Antibodies) activation and suggest that Erbin may play a role in breast cancer progression.
DSG1 (show DSG1 Antibodies) and Erbin cooperate to repress MAPK (show MAPK1 Antibodies) signaling and promote keratinocyte differentiation.
These results unravel a critical role of c-Myb (show MYB Antibodies) in promoting Erbin transcription in G2/M phase and also predict an unappreciated function of Erbin in cell cycle progression.
Overexpression of FHL2 (show FHL2 Antibodies) alone had no effect on Erbin expression, but in the presence of MITF (show MITF Antibodies), Erbin expression was decreased.
By degrading Erbin and Nrf2 (show NFE2L2 Antibodies), Sag (show RNF7 Antibodies) activates the Ras-Raf (show RAF1 Antibodies) pathway and causes ROS (show ROS1 Antibodies) accumulation to trigger autophagy and senescence
Results support that hyperglycemia may impair NRG1 (show NRG1 Antibodies)/Erb (show ESR2 Antibodies) B2 signaling by disrupting the balance between NRG1 (show NRG1 Antibodies) isoforms, decreasing the expression of erbin and correspondingly activating the MAPK (show MAPK1 Antibodies) pathway
Erbin is an inhibitor of pathological cardiac hypertrophy.
These observations demonstrate a crucial function for Erbin in AMPAR surface expression in cortical parvalbumin (show PVALB Antibodies) positive interneurons
This study demonistrated that demonstrate that Erbin is required for remyelination of regenerated axons after injury, probably by regulating ErbB2 (show ERBB2 Antibodies) and NRG1 (show NRG1 Antibodies) levels, identifying a novel player in regulating remyelination.
preliminary characterization of its interaction with Smad3 (show SMAD3 Antibodies)
erbin regulates MAP kinase (show MAPK1 Antibodies) activation in Schwann cells and suggest that erbin links merlin (show NF2 Antibodies) to both adherens junction protein complexes and the MAP kinase (show MAPK1 Antibodies) signaling pathway.
Erbin is a regulator of Nod2 (show NOD2 Antibodies)-dependent NF-kappaB (show NFKB1 Antibodies) signaling with a role in inflammatory responses
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, protein LAP2
, erbb2 interacting protein
, ERBB2 interacting protein
, protein LAP2-like
, erbb2-interacting protein
, similar to Erbb2 interacting protein isoform 2