Browse our anti-G Protein-Coupled Estrogen Receptor 1 (GPER) Antibodies

Cow (Bovine) G Protein-Coupled Estrogen Receptor 1 (GPER) interaction partners

1. PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1

Horse (Equine) G Protein-Coupled Estrogen Receptor 1 (GPER) interaction partners

1. Estradiol can weakly modulate the motility and this effect is strictly associated with GPER and not with ESR1 (show ESR1 Antibodies) and ESR2 (show ESR2 Antibodies). The subcellular localization of GPER in the neck on stallion sperm is coherent with this effect.

2. The presence of a single isoform of ESR1 (show ESR1 Antibodies) (66kDa (show SF3A2 Antibodies)) and ESR2 (show ESR2 Antibodies) (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.

Human G Protein-Coupled Estrogen Receptor 1 (GPER) interaction partners

1. These data thus demonstrate that estrogen prevents the failure of endothelial cell tube formation induced byhypoxia/reoxygenation. GPR30 plays an important role in these protective effects through the activation of eNOS (show NOS3 Antibodies) and Akt (show AKT1 Antibodies) in endothelial cells.

2. Epigenetic down regulation of GPER acts as a tumor suppressor in colorectal cancer and its specific activation might be a potential approach for colorectal cancer treatment.

3. Data suggest that IGF-I (show IGF1 Antibodies)/IGF-IR system triggers stimulatory actions through both GPER and DDR1 (show DDR1 Antibodies) in aggressive tumors as mesothelioma and lung tumors.

4. Na+/H+ exchanger regulatory factor (NHERF1 (show SLC9A3R1 Antibodies)) expression level positively associates with G protein-coupled estrogen receptor (show ESR1 Antibodies) (GPER) activation in ER-positive breast cancer.

5. Membrane estrogen receptor beta (show ESR2 Antibodies) and GPER signaling mediate cellular responses to environmentally relevant concentrations of CdCl2 and NaAsO2 in lung adenocarcinoma cells.

6. The G protein-coupled estrogen receptor (show ESR1 Antibodies) agonist G-1 inhibits nuclear estrogen receptor (show ESR1 Antibodies) activity and stimulates novel phosphoproteomic signatures in MCF-7 cells.

7. Utilizing both genetic and pharmacologic approaches, the authors establish that sex steroid effects on human melanin synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (show ESR1 Antibodies) (GPER), and progestin and adipoQ receptor 7 (PAQR7 (show PAQR7 Antibodies)).

8. These clinical data showed that the expression of G-protein coupled estrogen receptor (show ESR1 Antibodies) (GPER) is negatively associated with lymph node metastasis, high-grade tumor and fibronectin (FN (show FN1 Antibodies)) expression while positively associated with the favorable outcome in 135 triple negative breast cancer cells patients.

9. Data suggest that, under agonism of estrogens, ESR1 (show ESR1 Antibodies) exhibits a generally anxiogenic effect, ESR2 (show ESR2 Antibodies) exhibits a generally anxiolytic effect, and GPR30 exhibits both anxiogenic and anxiolytic effects. (ESR1 (show ESR1 Antibodies) = estrogen receptor 1/alpha (show ESR1 Antibodies); ESR2 (show ESR2 Antibodies) = estrogen receptor 2/beta (show ESR2 Antibodies); GPR30 = G protein-coupled estrogen receptor 1) [REVIEW]

10. Either by specific inhibitors for GPER, ERK (show EPHB2 Antibodies), AKT (show AKT1 Antibodies) and NF-kappaB (show NFKB1 Antibodies), or by knock-down of GPER.

Mouse (Murine) G Protein-Coupled Estrogen Receptor 1 (GPER) interaction partners

1. Study demonstrates that selective activation of G protein-coupled estrogen receptor (show ESR1 Antibodies) can control microglial activation induced by an inflammatory stimulus in vitro, and promote neuronal and functional protection of DA neurons against a unilateral intranigral injection of LPS (show TLR4 Antibodies) in male mice.neuroinflammatory diseases.

2. it suppresses lipopolysaccharide-induced interleukin 6 (show IL6 Antibodies) via inhibition of nuclear factor-kappa B pathway in murine macrophage cells

3. this study revealed a role for GPER activity in regulating Nox1 (show NOX1 Antibodies) abundance and associated O2(-)-mediated structural and functional damage that contributes to disease pathology

4. These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER receptor; thus, antagonism of GPER represents a potential new target for treatment to reduce metastatic spread.

5. GPER protects against hepatic tumorigenesis by regulating inflammatory responses.

6. Data suggest that prenatal exposure to p,p'-DDT (show DDT Antibodies) (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT (show DDT Antibodies)-induced depressive-like neurotoxicity.

7. Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt (show AKT1 Antibodies) signaling for Ask1 (show MAP3K5 Antibodies) inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.

8. Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta (show ESR2 Antibodies) and the G protein-coupled estrogen receptor (show ESR1 Antibodies).

9. Our study demonstrated the ameliorative role of GPR30 in NOR memory impaired by AD pathology in female mice

10. identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 (show ECE2 Antibodies) and the ETB (show EDNRB Antibodies) receptor, which is compatible with an activating role of GPER for the local endothelin system with aging