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Human Polyclonal GPER Primary Antibody for IF, IHC (p) - ABIN271054
Alyea, Laurence, Kim, Katzenellenbogen, Katzenellenbogen, Watson: The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells. in Journal of neurochemistry 2008
Show all 12 Pubmed References
Human Polyclonal GPER Primary Antibody for FACS, ICC - ABIN441270
Tian, Wang, Shi, Li, Wang, Zhu, Lin, Gui, Zheng: Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle. in Fertility and sterility 2012
Show all 6 Pubmed References
Human Polyclonal GPER Primary Antibody for IHC (p), WB - ABIN4315518
Hofmeister, Damkier, Christensen, Olde, Fredrik Leeb-Lundberg, Fenton, Praetorius, Praetorius: 17β-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1. in American journal of physiology. Renal physiology 2012
Show all 4 Pubmed References
Human Polyclonal GPER Primary Antibody for IF (p), IHC (p) - ABIN685717
Wang, Zhao, Lin, Groban: Activation of GPR30 inhibits cardiac fibroblast proliferation. in Molecular and cellular biochemistry 2015
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Cow (Bovine) Polyclonal GPER Primary Antibody for ICC, IF - ABIN5541520
Ding, Han, Li, Zhao, He, Zhang: Neurogenin 3-directed cre deletion of Tsc1 gene causes pancreatic acinar carcinoma. in Neoplasia (New York, N.Y.) 2014
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Human Polyclonal GPER Primary Antibody for ICC, IHC - ABIN1048791
Vivacqua, Bonofiglio, Recchia, Musti, Picard, Andò, Maggiolini: The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. in Molecular endocrinology (Baltimore, Md.) 2006
Show all 2 Pubmed References
Dog (Canine) Polyclonal GPER Primary Antibody for IF, IHC (p) - ABIN4315517
Spary, Chapman, Sinfield, Maqbool, Kaye, Batten: Novel G protein-coupled oestrogen receptor GPR30 shows changes in mRNA expression in the rat brain over the oestrous cycle. in Neuro-Signals 2013
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Human Polyclonal GPER Primary Antibody for ELISA, IHC (p) - ABIN271052
Park, Zhang, Liu, Kozlowski, Zhang, Lee: 17Beta-estradiol at low concentrations acts through distinct pathways in normal versus benign prostatic hyperplasia-derived prostate stromal cells. in Endocrinology 2009
Human Polyclonal GPER Primary Antibody for IF, IHC (p) - ABIN122586
Ignatov, Modl, Thulig, Weißenborn, Treeck, Ortmann, Zenclussen, Costa, Kalinski, Ignatov: GPER-1 acts as a tumor suppressor in ovarian cancer. in Journal of ovarian research 2013
Human Polyclonal GPER Primary Antibody for FACS, IHC - ABIN5680600
Broselid, Berg, Chavera, Kahn, Clarke, Olde, Leeb-Lundberg et al.: G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits ... in The Journal of biological chemistry 2015
PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
Estradiol can weakly modulate the motility and this effect is strictly associated with GPER and not with ESR1 and ESR2. The subcellular localization of GPER in the neck on stallion sperm is coherent with this effect.
The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
GPER mRNA and protein levels were significantly lower in gastric cancer tissue and cells lined when compared with normal tissues and cells.
Our findings implicate the GPER/HIF-1A axis as a master regulator of peri-tumoral stromal remodeling and the fibrovascular tumor microenvironment and offer a paradigm shift for tamoxifen from a well-established drug in breast cancer hormonal therapy to an alternative candidate for stromal targeting strategies in Pancreatic ductal adenocarcinoma and possibly other cancers.
Our results highlight GPER as a mechanical regulator of the tumor microenvironment that targets the three hallmarks of pancreatic cancer: desmoplasia, inflammation, and immune suppression. The well-established safety of tamoxifen in clinics may offer the possibility to redirect the singular focus of tamoxifen on the cancer cells to the greater tumor microenvironment and lead a new strategy of drug repurposing.
GPER-1 expression is a favorable prognostic factor in breast cancer patients
For children with ADHD, the social function of those with a TC genotype of the GPER gene c.-9T/C locus is more severely damaged compared with those with a TT genotype.
AMF contributes to GPER-1-mediated endometrial cancer progression.
The ERalpha and ERbeta are also involved in membrane-delineated signaling alongside membrane-specific G protein-coupled estrogen receptor 1 (GPER1), ER-X, and the Gq-coupled membrane ER (Gq-mER).
estrogenic GPER signaling may be considered among the transduction mechanisms engaging FAK toward breast cancer progression.
In an analysis of zebrafish and human liver cells and tissues, we found GPER1 to be a hepatic estrogen sensor that regulates liver growth during development, regeneration, and tumorigenesis.
GPER-mediated estrogen signalling in the mechanosensory-driven activation of HSCs.
GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic.
G15 to block GPER signaling may be considered as a new therapeutic target in NSCLC.
GPR30 signaling contributes to malignant potentials of cervical adenocarcinoma cells.Claudin-1 expression is regulated by GPR30 signaling in the cervical adenocarcinoma cells.
Activation of GPER can suppress the migration and invasion of OS cells via FBXL5-mediated post-translational down regulation of Snail. It suggested that targeted activation of GPER might be a potent potential therapy approach to overcome the metastasis of OS patients
serum levels of GPER, but not estrogen, are significantly decreased in ADHD patients compared to controls
The findings indicate that GPER/miR148a/HLAG signaling pathway may mediates the development of ovarian endometriosis and may become a potential therapeutic target for the treatment of endometriosis.
Nuclear GPR30 is overexpressed and predicts poor survival in patients with ovarian cancer.
These findings shed new light on the essential role played by GPER in IGF1/IGF1R signaling that induces breast tumor angiogenesis.
The significant and consistent increase in GPER expression in adenomyosis compared with control subjects, regardless of whether it was in the proliferative or secretory phases and regardless of whether it was in the JZ or OM, suggests that GPER plays an important role in the pathogenesis of the adenomyosis
Levels of GPR30 were significantly reduced in placentae from women with preeclampsia as compared with uncomplicated pregnancies.
GPER with ERs and P450arom work in tandem to maintain Leydig cell architecture and supervise its steroidogenic function by estrogen during male life.
Gene Set Enrichment Analysis (GSEA) revealed that mitochondrial genes are enriched in GPER KO females, whereas inflammatory response genes are enriched in GPER KO males, compared to their wild type counterparts of the same sex. The cardiomyocyte-specific GPER KO mouse model provides us with a powerful tool to study the functions of GPER in cardiomyocytes.
For the first time, we report here the importance of GPER-PPARalpha and -PPARgamma 'neopartnership' in maintenance of Leydig cell morpho-functional status.
In murine osteoblasts cultured in vitro, treatment with 17beta-estradiol resulted in the expression of GPR30 and enhanced mitophagy through the GPR30 and ERK1/2 signaling pathway.
findings provide evidence for the first time that GPR30 promotes adipogenesis and therefore the development of obesity in female mice exposed to excess fat energy
Study demonstrates that selective activation of G protein-coupled estrogen receptor can control microglial activation induced by an inflammatory stimulus in vitro, and promote neuronal and functional protection of DA neurons against a unilateral intranigral injection of LPS in male mice.neuroinflammatory diseases.
it suppresses lipopolysaccharide-induced interleukin 6 via inhibition of nuclear factor-kappa B pathway in murine macrophage cells
this study revealed a role for GPER activity in regulating Nox1 abundance and associated O2(-)-mediated structural and functional damage that contributes to disease pathology
These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER receptor; thus, antagonism of GPER represents a potential new target for treatment to reduce metastatic spread.
GPER protects against hepatic tumorigenesis by regulating inflammatory responses.
Data suggest that prenatal exposure to p,p'-DDT (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT-induced depressive-like neurotoxicity.
Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt signaling for Ask1 inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.
Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta and the G protein-coupled estrogen receptor.
Our study demonstrated the ameliorative role of GPR30 in NOR memory impaired by AD pathology in female mice
identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 and the ETB receptor, which is compatible with an activating role of GPER for the local endothelin system with aging
We suggest that activation of GPER exerts an inhibitory effect on colonic motility by promoting nitric oxide release from myenteric nitrergic nerves
GPR30 is expressed in diverse intracellular compartments in undifferentiated and differentiated C2C12 cells and mediates estradiol actions.
Results demonstrate that ERalpha, ERbeta, and GPER1 all participate in the rapid effects of 17beta-estradiol-3-benzoate on hippocampal synaptic function
GPR30 can mediate the fast effect of estrogen on blastocysts and play an important role in embryo implantation.
the pharmacology and signalling properties of GPER1 in an immortalized embryonic hippocampal cell line, are reported.
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.
G protein-coupled estrogen receptor 1
, G-protein coupled estrogen receptor 1-like
, G protein-coupled receptor 30
, G-protein coupled estrogen receptor 1
, G-protein coupled receptor 30
, IL8-related receptor DRY12
, chemoattractant receptor-like 2
, chemokine receptor-like 2
, constitutively expressed peptide-like receptor
, flow-induced endothelial G-protein coupled receptor 1
, heptahelix receptor
, leucine rich protein in GPR30 3'UTR
, lymphocyte-derived G-protein coupled receptor
, membrane estrogen receptor
, constitutively expressed peptide-like receptor like
, G-protein coupled receptor 41