Browse our anti-G Protein-Coupled Estrogen Receptor 1 (GPER) Antibodies

Cow (Bovine) G Protein-Coupled Estrogen Receptor 1 (GPER) interaction partners

1. PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1

Horse (Equine) G Protein-Coupled Estrogen Receptor 1 (GPER) interaction partners

1. Estradiol can weakly modulate the motility and this effect is strictly associated with GPER and not with ESR1 and ESR2. The subcellular localization of GPER in the neck on stallion sperm is coherent with this effect.

2. The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.

Human G Protein-Coupled Estrogen Receptor 1 (GPER) interaction partners

1. GPER mRNA and protein levels were significantly lower in gastric cancer tissue and cells lined when compared with normal tissues and cells.

2. Our findings implicate the GPER/HIF-1A axis as a master regulator of peri-tumoral stromal remodeling and the fibrovascular tumor microenvironment and offer a paradigm shift for tamoxifen from a well-established drug in breast cancer hormonal therapy to an alternative candidate for stromal targeting strategies in Pancreatic ductal adenocarcinoma and possibly other cancers.

3. Our results highlight GPER as a mechanical regulator of the tumor microenvironment that targets the three hallmarks of pancreatic cancer: desmoplasia, inflammation, and immune suppression. The well-established safety of tamoxifen in clinics may offer the possibility to redirect the singular focus of tamoxifen on the cancer cells to the greater tumor microenvironment and lead a new strategy of drug repurposing.

4. GPER-1 expression is a favorable prognostic factor in breast cancer patients

5. For children with ADHD, the social function of those with a TC genotype of the GPER gene c.-9T/C locus is more severely damaged compared with those with a TT genotype.

6. AMF contributes to GPER-1-mediated endometrial cancer progression.

7. The ERalpha and ERbeta are also involved in membrane-delineated signaling alongside membrane-specific G protein-coupled estrogen receptor 1 (GPER1), ER-X, and the Gq-coupled membrane ER (Gq-mER).

8. estrogenic GPER signaling may be considered among the transduction mechanisms engaging FAK toward breast cancer progression.

9. In an analysis of zebrafish and human liver cells and tissues, we found GPER1 to be a hepatic estrogen sensor that regulates liver growth during development, regeneration, and tumorigenesis.

10. GPER-mediated estrogen signalling in the mechanosensory-driven activation of HSCs.

11. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic.

12. G15 to block GPER signaling may be considered as a new therapeutic target in NSCLC.

13. GPR30 signaling contributes to malignant potentials of cervical adenocarcinoma cells.Claudin-1 expression is regulated by GPR30 signaling in the cervical adenocarcinoma cells.

14. Activation of GPER can suppress the migration and invasion of OS cells via FBXL5-mediated post-translational down regulation of Snail. It suggested that targeted activation of GPER might be a potent potential therapy approach to overcome the metastasis of OS patients

15. serum levels of GPER, but not estrogen, are significantly decreased in ADHD patients compared to controls

16. The findings indicate that GPER/miR148a/HLAG signaling pathway may mediates the development of ovarian endometriosis and may become a potential therapeutic target for the treatment of endometriosis.

17. Nuclear GPR30 is overexpressed and predicts poor survival in patients with ovarian cancer.

18. These findings shed new light on the essential role played by GPER in IGF1/IGF1R signaling that induces breast tumor angiogenesis.

19. The significant and consistent increase in GPER expression in adenomyosis compared with control subjects, regardless of whether it was in the proliferative or secretory phases and regardless of whether it was in the JZ or OM, suggests that GPER plays an important role in the pathogenesis of the adenomyosis

20. Levels of GPR30 were significantly reduced in placentae from women with preeclampsia as compared with uncomplicated pregnancies.

Mouse (Murine) G Protein-Coupled Estrogen Receptor 1 (GPER) interaction partners

1. GPER with ERs and P450arom work in tandem to maintain Leydig cell architecture and supervise its steroidogenic function by estrogen during male life.

2. Gene Set Enrichment Analysis (GSEA) revealed that mitochondrial genes are enriched in GPER KO females, whereas inflammatory response genes are enriched in GPER KO males, compared to their wild type counterparts of the same sex. The cardiomyocyte-specific GPER KO mouse model provides us with a powerful tool to study the functions of GPER in cardiomyocytes.

3. For the first time, we report here the importance of GPER-PPARalpha and -PPARgamma 'neopartnership' in maintenance of Leydig cell morpho-functional status.

4. In murine osteoblasts cultured in vitro, treatment with 17beta-estradiol resulted in the expression of GPR30 and enhanced mitophagy through the GPR30 and ERK1/2 signaling pathway.

5. findings provide evidence for the first time that GPR30 promotes adipogenesis and therefore the development of obesity in female mice exposed to excess fat energy

6. Study demonstrates that selective activation of G protein-coupled estrogen receptor can control microglial activation induced by an inflammatory stimulus in vitro, and promote neuronal and functional protection of DA neurons against a unilateral intranigral injection of LPS in male mice.neuroinflammatory diseases.

7. it suppresses lipopolysaccharide-induced interleukin 6 via inhibition of nuclear factor-kappa B pathway in murine macrophage cells

8. this study revealed a role for GPER activity in regulating Nox1 abundance and associated O2(-)-mediated structural and functional damage that contributes to disease pathology

9. These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER receptor; thus, antagonism of GPER represents a potential new target for treatment to reduce metastatic spread.

10. GPER protects against hepatic tumorigenesis by regulating inflammatory responses.

11. Data suggest that prenatal exposure to p,p'-DDT (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT-induced depressive-like neurotoxicity.

12. Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt signaling for Ask1 inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.

13. Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta and the G protein-coupled estrogen receptor.

14. Our study demonstrated the ameliorative role of GPR30 in NOR memory impaired by AD pathology in female mice

15. identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 and the ETB receptor, which is compatible with an activating role of GPER for the local endothelin system with aging

16. We suggest that activation of GPER exerts an inhibitory effect on colonic motility by promoting nitric oxide release from myenteric nitrergic nerves

17. GPR30 is expressed in diverse intracellular compartments in undifferentiated and differentiated C2C12 cells and mediates estradiol actions.

18. Results demonstrate that ERalpha, ERbeta, and GPER1 all participate in the rapid effects of 17beta-estradiol-3-benzoate on hippocampal synaptic function

19. GPR30 can mediate the fast effect of estrogen on blastocysts and play an important role in embryo implantation.

20. the pharmacology and signalling properties of GPER1 in an immortalized embryonic hippocampal cell line, are reported.