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Human Polyclonal GPER Primary Antibody for IF, IHC (p) - ABIN271054
Alyea, Laurence, Kim, Katzenellenbogen, Katzenellenbogen, Watson: The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells. in Journal of neurochemistry 2008
Show all 10 Pubmed References
Human Polyclonal GPER Primary Antibody for FACS, ICC - ABIN441270
Tian, Wang, Shi, Li, Wang, Zhu, Lin, Gui, Zheng: Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle. in Fertility and sterility 2012
Show all 5 Pubmed References
Human Polyclonal GPER Primary Antibody for IF (p), IHC (p) - ABIN685717
Wang, Zhao, Lin, Groban: Activation of GPR30 inhibits cardiac fibroblast proliferation. in Molecular and cellular biochemistry 2015
Show all 3 Pubmed References
Human Polyclonal GPER Primary Antibody for IHC (p), WB - ABIN4315518
Hofmeister, Damkier, Christensen, Olde, Fredrik Leeb-Lundberg, Fenton, Praetorius, Praetorius: 17β-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1. in American journal of physiology. Renal physiology 2012
Show all 3 Pubmed References
Human Polyclonal GPER Primary Antibody for IHC (p), WB - ABIN1048791
Vivacqua, Bonofiglio, Recchia, Musti, Picard, Andò, Maggiolini: The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells. in Molecular endocrinology (Baltimore, Md.) 2006
Show all 2 Pubmed References
Dog (Canine) Polyclonal GPER Primary Antibody for IF, IHC (p) - ABIN4315517
Spary, Chapman, Sinfield, Maqbool, Kaye, Batten: Novel G protein-coupled oestrogen receptor GPR30 shows changes in mRNA expression in the rat brain over the oestrous cycle. in Neuro-Signals 2013
Show all 2 Pubmed References
Human Polyclonal GPER Primary Antibody for IF, IHC (p) - ABIN122586
Ignatov, Modl, Thulig, Weißenborn, Treeck, Ortmann, Zenclussen, Costa, Kalinski, Ignatov: GPER-1 acts as a tumor suppressor in ovarian cancer. in Journal of ovarian research 2013
Human Polyclonal GPER Primary Antibody for ELISA, IHC (p) - ABIN271052
Park, Zhang, Liu, Kozlowski, Zhang, Lee: 17Beta-estradiol at low concentrations acts through distinct pathways in normal versus benign prostatic hyperplasia-derived prostate stromal cells. in Endocrinology 2009
Human Polyclonal GPER Primary Antibody for WB - ABIN1537181
Altmann, Yan, Meeks, Abood, Brailoiu, Brailoiu: G protein-coupled estrogen receptor-mediated effects on cytosolic calcium and nanomechanics in brain microvascular endothelial cells. in Journal of neurochemistry 2015
PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
Estradiol can weakly modulate the motility and this effect is strictly associated with GPER and not with ESR1 (show ESR1 Antibodies) and ESR2 (show ESR2 Antibodies). The subcellular localization of GPER in the neck on stallion sperm is coherent with this effect.
The presence of a single isoform of ESR1 (show ESR1 Antibodies) (66kDa (show SF3A2 Antibodies)) and ESR2 (show ESR2 Antibodies) (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
These data thus demonstrate that estrogen prevents the failure of endothelial cell tube formation induced byhypoxia/reoxygenation. GPR30 plays an important role in these protective effects through the activation of eNOS (show NOS3 Antibodies) and Akt (show AKT1 Antibodies) in endothelial cells.
Epigenetic down regulation of GPER acts as a tumor suppressor in colorectal cancer and its specific activation might be a potential approach for colorectal cancer treatment.
Data suggest that IGF-I (show IGF1 Antibodies)/IGF-IR system triggers stimulatory actions through both GPER and DDR1 (show DDR1 Antibodies) in aggressive tumors as mesothelioma and lung tumors.
Na+/H+ exchanger regulatory factor (NHERF1 (show SLC9A3R1 Antibodies)) expression level positively associates with G protein-coupled estrogen receptor (show ESR1 Antibodies) (GPER) activation in ER-positive breast cancer.
Membrane estrogen receptor beta (show ESR2 Antibodies) and GPER signaling mediate cellular responses to environmentally relevant concentrations of CdCl2 and NaAsO2 in lung adenocarcinoma cells.
The G protein-coupled estrogen receptor (show ESR1 Antibodies) agonist G-1 inhibits nuclear estrogen receptor (show ESR1 Antibodies) activity and stimulates novel phosphoproteomic signatures in MCF-7 cells.
Utilizing both genetic and pharmacologic approaches, the authors establish that sex steroid effects on human melanin synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (show ESR1 Antibodies) (GPER), and progestin and adipoQ receptor 7 (PAQR7 (show PAQR7 Antibodies)).
These clinical data showed that the expression of G-protein coupled estrogen receptor (show ESR1 Antibodies) (GPER) is negatively associated with lymph node metastasis, high-grade tumor and fibronectin (FN (show FN1 Antibodies)) expression while positively associated with the favorable outcome in 135 triple negative breast cancer cells patients.
Data suggest that, under agonism of estrogens, ESR1 (show ESR1 Antibodies) exhibits a generally anxiogenic effect, ESR2 (show ESR2 Antibodies) exhibits a generally anxiolytic effect, and GPR30 exhibits both anxiogenic and anxiolytic effects. (ESR1 (show ESR1 Antibodies) = estrogen receptor 1/alpha (show ESR1 Antibodies); ESR2 (show ESR2 Antibodies) = estrogen receptor 2/beta (show ESR2 Antibodies); GPR30 = G protein-coupled estrogen receptor 1) [REVIEW]
Either by specific inhibitors for GPER, ERK (show EPHB2 Antibodies), AKT (show AKT1 Antibodies) and NF-kappaB (show NFKB1 Antibodies), or by knock-down of GPER.
Study demonstrates that selective activation of G protein-coupled estrogen receptor (show ESR1 Antibodies) can control microglial activation induced by an inflammatory stimulus in vitro, and promote neuronal and functional protection of DA neurons against a unilateral intranigral injection of LPS (show TLR4 Antibodies) in male mice.neuroinflammatory diseases.
it suppresses lipopolysaccharide-induced interleukin 6 (show IL6 Antibodies) via inhibition of nuclear factor-kappa B pathway in murine macrophage cells
this study revealed a role for GPER activity in regulating Nox1 (show NOX1 Antibodies) abundance and associated O2(-)-mediated structural and functional damage that contributes to disease pathology
These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER receptor; thus, antagonism of GPER represents a potential new target for treatment to reduce metastatic spread.
GPER protects against hepatic tumorigenesis by regulating inflammatory responses.
Data suggest that prenatal exposure to p,p'-DDT (show DDT Antibodies) (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT (show DDT Antibodies)-induced depressive-like neurotoxicity.
Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt (show AKT1 Antibodies) signaling for Ask1 (show MAP3K5 Antibodies) inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.
Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta (show ESR2 Antibodies) and the G protein-coupled estrogen receptor (show ESR1 Antibodies).
Our study demonstrated the ameliorative role of GPR30 in NOR memory impaired by AD pathology in female mice
identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 (show ECE2 Antibodies) and the ETB (show EDNRB Antibodies) receptor, which is compatible with an activating role of GPER for the local endothelin system with aging
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.
G protein-coupled estrogen receptor 1
, G-protein coupled estrogen receptor 1-like
, G protein-coupled receptor 30
, G-protein coupled estrogen receptor 1
, G-protein coupled receptor 30
, IL8-related receptor DRY12
, chemoattractant receptor-like 2
, chemokine receptor-like 2
, constitutively expressed peptide-like receptor
, flow-induced endothelial G-protein coupled receptor 1
, heptahelix receptor
, leucine rich protein in GPR30 3'UTR
, lymphocyte-derived G-protein coupled receptor
, membrane estrogen receptor
, constitutively expressed peptide-like receptor like
, G-protein coupled receptor 41