GPER antibody (C-Term)

Catalog No. ABIN952589

The Rabbit Polyclonal anti-GPER antibody is suitable to detect GPER in samples from Human and Mouse. It has been validated for WB and EIA.

Quick Overview for GPER antibody (C-Term) (ABIN952589)

Target: GPER (G Protein-Coupled Estrogen Receptor 1 (GPER))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPER antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-GPER Antibody

Binding Specificity: AA 345-375, C-Term

Specificity: This antibody reacts to GPER.

Cross-Reactivity (Details): Species reactivity (tested):Human and Mouse.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 345-375 amino acids from the C-terminal region of human GPER

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GPER

Target: GPER (G Protein-Coupled Estrogen Receptor 1 (GPER))

Alternative Name: GPER / GPR30

Background: This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq].Synonyms: CEPR, CMKRL2, Chemoattractant receptor-like 2, DRY12, FEG1, Flow-induced endothelial G-protein coupled receptor 1, G-protein coupled estrogen receptor 1, G-protein coupled receptor 30, GPCR-BR, IL8-related receptor DRY12, LYGPR, Lymphocyte-derived G-protein coupled receptor

Molecular Weight: 42248 Da

Gene ID: 2852

NCBI Accession: NP_001035055

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process