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Cow (Bovine) Polyclonal PDE6G Primary Antibody for IP, ELISA - ABIN2747191
Nikolova, Guenther, Savai, Weissmann, Ghofrani, Konigshoff, Eickelberg, Klepetko, Voswinckel, Seeger, Grimminger, Schermuly, Pullamsetti: Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis. in Respiratory research 2011
Collectively, we report previously unrecognized PDE6 expression in human lungs, significant alterations of the PDE6D and PDE6G/H subunits in IPF lungs.
These findings demonstrate the positive role of the gamma subunit in maintaining phosphodiesterase activity and confirm the contribution of PDE6G to the etiology of retinitis pigmentosa in humans.
The C-terminus of PED gamma occludes the active site of PDE6, thereby preventing hydrolysis of cGMP.
PDEG functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor
Crystal structures of a chimaeric PDE5/PDE6 catalytic domain (PDE5/6cd) complexed with sildenafil or 3-isobutyl-1-methylxanthine and the Pgamma-inhibitory peptide Pgamma(70-87) have been determined at 2.9 and 3.0 A, respectively.
AIPL1-mediated production of folded PDE6C is markedly elevated in the presence of the inhibitory Pgamma-subunit of PDE6.
The presence of rod PDE6G in cones indicating functional substitution of PDE6h in mice.
our results show for the first time that the Ile(86) and Ile(87) residues of PDE6-gamma are necessary for normal inhibition of PDE6 catalytic activity in vivo
PDE6gamma is a major component of the photoresponse and is required to support rod integrity.
Results suggest that the polycationic domain of PDE6 gamma containing these two phosphorylation sites can influence the rate of PDE6 activation and could modify the time course of transduction, thereby influencing the wave form of the light response.
The approximately 11 A map revealed previously unseen features of PDE6, and each domain was readily fit with high resolution structures.
The 3D structure of the PDE6alphabetagamma complex was determined up to 18 A resolution from single-particle projections and was interpreted by model building to identify the probable location of isoprenylation, PDE6gamma subunits, and catalytic site
Transducin activation of PDE6 appears to require interaction with both the C terminus and other regions of Pgamma to effectively relieve its inhibitory constraint.
Structural analysis of cGMP phosphodiesterase 6 alpha, beta and gamma interactions
the unique Palphabeta heterodimer contributes to the sophisticated regulation in visual transduction through interaction with Pgamma
The Pgamma N-terminal Val16-Phe30 region was found to interact with the Palphabeta GAFa domain, whereas its C terminus (Phe73-Ile87) interacted with the Palphabeta catalytic domain.
although Pgamma-mediated regulation plays the dominant role in visual excitation, the direct, inter-domain allosteric regulation may play a feedback role in light adaptational processes during phototransduction
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants.
, retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
, rod cG-PDE G
, phosphodiesterase 6 gamma subunit rod form
, cyclic-GMP phosphodiesterase gamma subunit
, cGMP phosphodiesterase gamma
, rod cyclic-GMP phosphodiesterase 6 gamma splice variant p3
, phosphodiesterase, cyclic GMP (rod receptor), gamma polypeptide
, phosphodiesterase 6G, cGMP-specific, rod, gamma
, cGMP-PDE6 gamma
, cGMP-phosphodiesterase 6 gamma subunit
, phosphodiesterase 6G L homeolog
, phosphodiesterase 6G S homeolog
, phosphodiesterase 6G, cGMP-specific, rod, gamma b