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RHBDF1 is an indispensable component of the protein trafficking machinery involved in GPCR-mediated EGFR transactivation, and is an attractive therapeutic target for cancer.
results explain how loss of the amino terminus in iRhom1 and iRhom2 impairs TNF signaling, despite enhancing ADAM17 activity
The expression of iRhom1 was increased by endoplasmic reticulum (ER) stressors, such as thapsigargin and tunicamycin, leading to the enhancement of proteasome activity, especially in ER-containing microsomes.
RHBDF1 is a critical component of a molecular switch that regulates HIF1alpha stability in cancer cells in hypoxia.
RHBDF1 is a seven-transmembrane protein with a long N-terminal cytoplasmic extension that comprises half of the polypeptide sequence, and is found in the endoplasmic reticulum and Golgi, but not on the cell surface
RHBDF1 has a pivotal role in sustaining growth signals in epithelial cancer cells and thus may serve as a therapeutic target for treating epithelial cancers.
RHBDF1 is critically involved in a G protein-coupled receptors ligand-stimulated process leading to the activation of latent epidermal growth factor receptor ligands
a principal function of iRhoms1/2 during mouse development is to regulate ADAM17-dependent EGFR signaling
iRhom1 knockout mice have a severe phenotype, impaired TACE maturation and die within 6 weeks of birth.
Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity).
rhomboid 5 homolog 1 (Drosophila)
, rhomboid family member 1
, rhomboid family member 1-like
, inactive rhomboid protein 1
, epidermal growth factor receptor, related sequence
, epidermal growth factor receptor-related protein
, rhomboid family 1
, Rhomboid family member 1
, epidermal growth factor receptor related sequence