Browse our anti-TGFB1 (TGFB1) Antibodies

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Following Schistosoma exposure, TSP-1 (show THBS1 Antibodies) levels in the lung increase, via recruitment of circulating monocytes, while TSP-1 (show THBS1 Antibodies) inhibition or knockout bone marrow prevents TGF-beta activation and protects against pulmonary hypertension development.

2. TGFbeta1 reduced complex IV protein MTCO1 (show COX1 Antibodies) abundance in both myoblasts and myotubes.

3. TGF-beta1 expression is regulated by PlncRNA-1 in breast cancer.

4. Elevated AhR (show AHR Antibodies) expression may be involved in the progression of tissue remodeling in chronic rhinosinusitis without nasal polyp without allergic rhinitis similar to TGF-beta1 expression

5. Overall, these findings suggest a more dominant role for SMAD3 (show SMAD3 Antibodies) and SMAD4 (show SMAD4 Antibodies) than SMAD2 (show SMAD2 Antibodies) in TGFbeta-induced chondrogenesis of human bone marrow-derived mesenchymal stem cells.

6. High TGF beta expression is associated with Chronic Periodontitis.

7. Fewer TIMP-2 (show TIMP2 Antibodies), Hsp70 (show HSP70 Antibodies) and TGF-beta1 immunoreactive cells in younger individuals and increased expression of Hsp70 (show HSP70 Antibodies) in elderly individuals demonstrated the influence of aging in lung remodeling

8. Data show that TGFbeta1-mediated EMT (show ITK Antibodies) involves CD44 (show CD44 Antibodies) splice isoform switching in ovarian cancer cells.

9. Gene silencing experiments of MLL4 (show MLL2 Antibodies) and the subunits PA1 (show PAGR1 Antibodies) and PTIP (show PAXIP1 Antibodies) confirm TGF-beta-specific genes to be regulated by the MLL4 (show MLL2 Antibodies) complex, which links TGF-beta signaling to transcription regulation by the MLL4 (show MLL2 Antibodies) methyltransferase complex.

10. TGF-beta1 is significantly overexpressed in tumor tissue samples of clear cell Renal cell carcinoma (show MOK Antibodies) patients. TGF-beta1 up-regulation could be responsible for the high levels of NNMT (show NNMT Antibodies) observed in clear cell Renal cell carcinoma (show MOK Antibodies) tissues.

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 stimulated lubricin (show PRG4 Antibodies) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (show PRG4 Antibodies) much higher compared with twice-a-week treatment.

2. hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Antibodies)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (show MME Antibodies)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

3. TGF-beta1 modulates the expression of syndecan-4 (show SDC4 Antibodies) in cultured vascular endothelial cells in a biphasic manner.

4. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (show FGF2 Antibodies) expression through the activation of AP-1 (show JUN Antibodies) and NF-kappaB (show NFKB1 Antibodies) in bovine mammary gland fibroblasts.

5. The results identify TGFB1 and ESRRA (show ESRRA Antibodies) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

6. the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Antibodies) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Antibodies) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Antibodies) secretion.

7. Tenascin-X (show TNXB Antibodies) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

9. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (show SMAD3 Antibodies) signaling pathway in chronic heart failure .

2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Antibodies), and the amelioration of disc degradation.

4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Antibodies) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

6. Smad7 (show SMAD7 Antibodies) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Antibodies) signaling target in limbal epithelial stem cells.

7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

8. After NOTCH1 (show NOTCH1 Antibodies) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Antibodies) and collagen II.

9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF beta is involved in the pathogenesis of tympanosclerosis.

2. There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Antibodies) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 regulated pAKT (show AKT1 Antibodies) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

2. SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Antibodies)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Antibodies) expression.

3. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Antibodies)+ T cells from mesentric lymph nodes.

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 is activated or inactivated by MMP20 or KLK4 (show KLK4 Antibodies) and that the amelogenin (show AMELX Antibodies) cleavage product is necessary for the in-solution mobility of TGF-beta1.

2. Activated TGF-beta signaling rescued miR (show MYLIP Antibodies)-143-reduced FSHR (show FSHR Antibodies) and intracellular signaling molecules, and miR (show MYLIP Antibodies)-143-induced porcine granulosa cell apoptosis.

3. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (show PTK2 Antibodies)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (show PTK2 Antibodies) signaling is inhibited.

4. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (show SMAD1 Antibodies) and MAPK (show MAPK1 Antibodies) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Antibodies) challenge

5. this study shows that anemonin may ameliorate LPS (show IRF6 Antibodies)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Antibodies) signaling pathways

6. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

7. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

8. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Antibodies), and IL-6 (show IL6 Antibodies) in ovarian follicles are reported.

9. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Antibodies) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

10. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Antibodies) signaling, reduces CFTR (show CFTR Antibodies) expression to impair CFTR (show CFTR Antibodies)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Antibodies) mutations and ultimately would compromise male fertility.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Antibodies) serves as a vegetally enriched, intrinsic factor (show GIF Antibodies) to ensure a prepared status of Smads for their activation.

3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Antibodies)

6. sortilin (show SORT1 Antibodies) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Within the limitations of the study design, production of COMP (show COMP Antibodies) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Following Schistosoma exposure, TSP-1 (show GZMA Antibodies) levels in the lung increase, via recruitment of circulating monocytes, while TSP-1 (show GZMA Antibodies) inhibition or knockout bone marrow prevents TGF-beta activation and protects against pulmonary hypertension development.

2. TGF-beta/Smad (show SMAD1 Antibodies) proteins signaling affects radiation response and prolongs survival by regulating DNA repair genes in malignant glioma.

3. The results indicate that EGFR (show EGFR Antibodies) and its activation are critical for YAP (show YAP1 Antibodies)-mediated suppression of TGF-beta1-induced apoptosis. This study provides a new understanding of the regulatory mechanism underlying the determination of cell fate in response to TGF-beta1-mediated simultaneous apoptosis and epithelial mesenchymal transformation.

4. transforming growth factor beta (TGFbeta) signaling was upregulated in HSCs from bone marrow of mice with MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies)-induced acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) because of excessive production of TGFbeta1, especially from megakaryocytes, and overactivation of latent TGFbeta1 protein.

5. TGF-beta release from platelets is necessary for podoplanin (show PDPN Antibodies)-mediated tumor invasion and metastasis in lung cancer.

6. Data suggest partial or complete transforming growth factor beta 1 (TGFBI) knockdown as a potential therapy against TGFBI-linked corneal dystrophies.

7. De novo formation of the biliary system by TGFbeta-mediated hepatocyte transdifferentiation

8. CXCL9 (show CXCL9 Antibodies) may promote prostate cancer progression via inhibition of cytokines from T cells.

9. EGCG attenuated airway inflammation in asthmatic mice, decreased the percentage of Th17 cells and increased the percentage of Treg cells. The antiinflammatory effect of EGCG is achieved via the TGFbeta1 signaling pathway.

10. fibrosis induced by Ang II (show AGT Antibodies) may be alleviated by AKAP12 (show AKAP12 Antibodies) expression through inactivation of the TGF-beta1 pathway.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Antibodies).

3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Antibodies) mediated pathway.

4. PCSK7 (show PCSK7 Antibodies) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

6. TGFbeta1 plays a role in zebrafish keratocyte migration.

7. data presented show that Zili (show PIWIL2 Antibodies) suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Antibodies) and preventing the formation of Smad2 (show SMAD2 Antibodies)/3/4 and Smad1 (show SMAD1 Antibodies)/5/9/4 complexes

8. TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Antibodies), 20beta-HSD (show HAL Antibodies) and membrane progestin receptor-beta (show PAQR8 Antibodies), to inhibit zebrafish oocyte maturation

9. These data suggest Pez (show PTPN14 Antibodies) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

10. Data show that Rock2 (show ROCK2 Antibodies) acts as a negative regulator of the TGFbeta signaling pathway.