Browse our anti-TGFB1 (TGFB1) Antibodies

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. This review analyzes the molecular mechanisms leading to TGFbeta dysregulation in tumor and stroma cells and the modification of the microenvironment that fosters colorectal cancer metastasis. [review]

2. theses results suggest that TGF-beta1 genotypes of recipient are the most associated with the risk of complications after haematopoietic stem cell transplantation

3. Studies indicate that transforming growth factor-beta (TGF-beta) signaling and receptor tyrosine kin (show KIN Antibodies) (RTK) pathways interact with each other and their interplay is important for cancer development [Review].

4. We found that PD-L1 (show CD274 Antibodies) expression was upregulated following TGF-beta induction; in contrast, it was downregulated by TGF-beta receptor-kinase inhibitors and the MET process. Furthermore, chemo-treatment increased TGF-beta expression and enhances PD-L1 (show CD274 Antibodies) expression via autocrine TGF-beta induced EMT (show ITK Antibodies). Analysis of clinical samples revealed a significant relationship between PD-L1 (show CD274 Antibodies) expression and EMT (show ITK Antibodies) status

5. TGF-beta1 promotes cells invasion and migration by inducing epithelial mesenchymal transformation in oral squamous cell carcinoma

6. Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population.

7. TGF-beta1 efficiently converted human acinar cells to duct-like cells (AD) in a SMAD (show SMAD1 Antibodies)-dependent manner, highlighting fundamental differences between the species

8. Plasma kallikrein (show KLKB1 Antibodies) (PLK (show PLK1 Antibodies))-dependent transforming growth factor-beta (TGF-beta) activation could be detected in isolated pancreatic stellate cells (PSCs) from chronic pancreatitis (CP) and pancreatic cancer.

9. rs1800469 in TGFB1 was associated to hepatic decompensation in chronic hepatitis C, while the other 11 described polymorphisms must be evaluated in a larger cohort to determine the possible role of vitamin D in hepatitis C.

10. isatuximab decreases multiple myeloma cell- and bone marrow stromal cell-induced iTreg by inhibiting both cell-cell contact and TGFbeta/IL10. Finally, CD38 levels correlate with differential inhibition by isatuximab of Tregs from multiple myeloma versus normal donors.Targeting CD38 by isatuximab can preferentially block immunosuppressive Tregs and thereby restore immune effector function against multiple myeloma

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 stimulated lubricin (show PRG4 Antibodies) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (show PRG4 Antibodies) much higher compared with twice-a-week treatment.

2. hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Antibodies)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (show MME Antibodies)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

3. TGF-beta1 modulates the expression of syndecan-4 (show SDC4 Antibodies) in cultured vascular endothelial cells in a biphasic manner.

4. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (show FGF2 Antibodies) expression through the activation of AP-1 (show JUN Antibodies) and NF-kappaB (show NFKB1 Antibodies) in bovine mammary gland fibroblasts.

5. The results identify TGFB1 and ESRRA (show ESRRA Antibodies) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

6. the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Antibodies) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Antibodies) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Antibodies) secretion.

7. Tenascin-X (show TNXB Antibodies) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

9. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (show SMAD3 Antibodies) signaling pathway in chronic heart failure .

2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Antibodies), and the amelioration of disc degradation.

4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Antibodies) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

6. Smad7 (show SMAD7 Antibodies) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Antibodies) signaling target in limbal epithelial stem cells.

7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

8. After NOTCH1 (show NOTCH1 Antibodies) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Antibodies) and collagen II.

9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF beta is involved in the pathogenesis of tympanosclerosis.

2. There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Antibodies) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 regulated pAKT (show AKT1 Antibodies) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

2. SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Antibodies)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Antibodies) expression.

3. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Antibodies)+ T cells from mesentric lymph nodes.

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 is activated or inactivated by MMP20 or KLK4 (show KLK4 Antibodies) and that the amelogenin (show AMELX Antibodies) cleavage product is necessary for the in-solution mobility of TGF-beta1.

2. Activated TGF-beta signaling rescued miR (show MYLIP Antibodies)-143-reduced FSHR (show FSHR Antibodies) and intracellular signaling molecules, and miR (show MYLIP Antibodies)-143-induced porcine granulosa cell apoptosis.

3. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (show PTK2 Antibodies)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (show PTK2 Antibodies) signaling is inhibited.

4. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (show SMAD1 Antibodies) and MAPK (show MAPK1 Antibodies) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Antibodies) challenge

5. this study shows that anemonin may ameliorate LPS (show IRF6 Antibodies)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Antibodies) signaling pathways

6. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

7. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

8. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Antibodies), and IL-6 (show IL6 Antibodies) in ovarian follicles are reported.

9. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Antibodies) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

10. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Antibodies) signaling, reduces CFTR (show CFTR Antibodies) expression to impair CFTR (show CFTR Antibodies)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Antibodies) mutations and ultimately would compromise male fertility.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Antibodies) serves as a vegetally enriched, intrinsic factor (show GIF Antibodies) to ensure a prepared status of Smads for their activation.

3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Antibodies)

6. sortilin (show SORT1 Antibodies) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Within the limitations of the study design, production of COMP (show COMP Antibodies) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. IL 6 (show IL6 Antibodies) and TGF beta perform essential role in cerebral malaria pathogenesis by modulating the level of glial cell induced neuroinflammation.

2. The increased susceptibility to IMQ-induced psoriasis of GILZ (show TSC22D3 Antibodies)-Tg mice was significantly associated with skin-specific over-activation of TGF-beta1-mediated signaling via SMAD2 (show SMAD2 Antibodies)/3.

3. The data suggest that B cells can down-regulate the function of antigen-presenting cells, and in turn encephalitogenic Th1 (show HAND1 Antibodies)/Th17 responses, via TGF-beta1.

4. p-SMAD2 (show SMAD2 Antibodies)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF (show CTGF Antibodies) exp p-SMAD2 (show SMAD2 Antibodies)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF (show CTGF Antibodies) expression during tooth development.

5. inhibiting NCAM1 (show NCAM1 Antibodies) would be cardioprotective, counteract the pathological action of TGFbeta1 and reduce heart failure severity.

6. TGF-beta signaling has a role in inhibiting tumor progression and invasion in an induced mouse bladder cancer model

7. calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2 (show MMP2 Antibodies)/TGF-beta1 pathway.

8. Suggest an essential role for platelet-derived TGFbeta1 for the vascular remodelling response to arterial injury, apparently independent from the role of platelets in thrombosis or haemostasis.

9. In cultured B16 melanoma and Bend3 endothelial cells treated with Bend3 conditioned media, MITF (show MITF Antibodies), tyrosinase (show TYR Antibodies), and melanin expression decreased due to TGFB1 secreted by the endothelial cells.

10. Lycat (show LCLAT1 Antibodies) regulates TGF-beta mediated lung fibroblast differentiation in pulmonary fibrosis.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Antibodies).

3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Antibodies) mediated pathway.

4. PCSK7 (show PCSK7 Antibodies) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

6. TGFbeta1 plays a role in zebrafish keratocyte migration.

7. data presented show that Zili (show PIWIL2 Antibodies) suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Antibodies) and preventing the formation of Smad2 (show SMAD2 Antibodies)/3/4 and Smad1 (show SMAD1 Antibodies)/5/9/4 complexes

8. TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Antibodies), 20beta-HSD (show HAL Antibodies) and membrane progestin receptor-beta (show PAQR8 Antibodies), to inhibit zebrafish oocyte maturation

9. These data suggest Pez (show PTPN14 Antibodies) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

10. Data show that Rock2 (show ROCK2 Antibodies) acts as a negative regulator of the TGFbeta signaling pathway.