Browse our anti-TGFB1 (TGFB1) Antibodies

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 regulated pAKT (show AKT1 Antibodies) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

2. These findings suggest that FBLN5 (show FBLN5 Antibodies) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Antibodies), CXCR4 (show CXCR4 Antibodies), and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.

3. SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Antibodies)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Antibodies) expression.

4. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Antibodies)+ T cells from mesentric lymph nodes.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Antibodies).

3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Antibodies) mediated pathway.

4. PCSK7 (show PCSK7 Antibodies) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

6. TGFbeta1 plays a role in zebrafish keratocyte migration.

7. data presented show that Zili (show PIWIL2 Antibodies) suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Antibodies) and preventing the formation of Smad2 (show SMAD2 Antibodies)/3/4 and Smad1 (show SMAD1 Antibodies)/5/9/4 complexes

8. TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Antibodies), 20beta-HSD (show HAL Antibodies) and membrane progestin receptor-beta (show PAQR8 Antibodies), to inhibit zebrafish oocyte maturation

9. These data suggest Pez (show PTPN14 Antibodies) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

10. Data show that Rock2 (show ROCK2 Antibodies) acts as a negative regulator of the TGFbeta signaling pathway.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Antibodies) serves as a vegetally enriched, intrinsic factor (show GIF Antibodies) to ensure a prepared status of Smads for their activation.

3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Antibodies)

6. sortilin (show SORT1 Antibodies) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. our findings suggest that tumor extracellular vesicle (EV)-educated mesenchymal stem cells promote osteosarcoma progression and provide the basis for testing IL6 (show IL6 Antibodies)- and TGFbeta-blocking agents as new therapeutic options for osteosarcoma patients.

2. Lipopolysaccharides-mediated TLR4 (show TLR4 Antibodies) signaling enhances TGF-beta response through downregulating BAMBI (show BAMBI Antibodies) during prostatic hyperplasia.

3. This work additionally suggests ILEI (show FAM3C Antibodies) mediates TGF-beta1-dependent Epithelial-to-mesenchymal transitions (EMTs) via the extracellular regulated protein kinases (ERKs) and protein kinase B (Akt (show AKT1 Antibodies)) signalling pathways.

4. conclude that Lipin-1 (show LPIN1 Antibodies) can antagonize HSC (show FUT1 Antibodies) activation through the inhibition of TGF-beta/SMAD (show SMAD1 Antibodies) signaling and that resveratrol may affect Lipin-1 (show LPIN1 Antibodies) gene induction and contribute to the inhibition of TGF-beta-mediated hepatic fibrogenesis

5. SARS (show SARS Antibodies) coronavirus papain-like protease significantly triggered Egr-1 (show EGR1 Antibodies) dependent activation of TGF-beta1 promoter via reactive oxygen species/p38 MAPK (show MAPK14 Antibodies)/STAT3 (show STAT3 Antibodies) pathway.

6. TGF-beta1 has a role in stimulating the migration of type II endometrial cancer cells by activating SMAD (inducing SMAD 2/3 phosphorylation and knocking down SMAD4) and ERK 1/2, which down-regulates PTEN

7. overview of primary cilia-mediated regulation of receptor tyrosine kinase (show RET Antibodies) (RTK- PDGFRa (show PDGFRA Antibodies) and PDGFRb (show PDGFRB Antibodies)) and transforming growth factor beta (TGF-beta) signaling [review]

8. The present study indicates that TGFB1 variants have subtype-specific roles in BC and may switch from tumor suppressor to promoter during tumor development, consistent with TGFbeta1 dual role in BC pathogenesis.

9. the expression of TGF-beta1 was related to shorter survival time and rapid progression for gastric cancer patients

10. Results suggest that high TGF-beta1 expression promotes a poor prognosis in hepatocellular carcinoma patients. [meta-analysis]

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Activated TGF-beta signaling rescued miR (show MYLIP Antibodies)-143-reduced FSHR (show FSHR Antibodies) and intracellular signaling molecules, and miR (show MYLIP Antibodies)-143-induced porcine granulosa cell apoptosis.

2. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (show PTK2 Antibodies)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (show PTK2 Antibodies) signaling is inhibited.

3. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (show SMAD1 Antibodies) and MAPK (show MAPK1 Antibodies) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Antibodies) challenge

4. this study shows that anemonin may ameliorate LPS (show IRF6 Antibodies)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Antibodies) signaling pathways

5. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

6. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

7. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Antibodies), and IL-6 (show IL6 Antibodies) in ovarian follicles are reported.

8. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Antibodies) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

9. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Antibodies) signaling, reduces CFTR (show CFTR Antibodies) expression to impair CFTR (show CFTR Antibodies)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Antibodies) mutations and ultimately would compromise male fertility.

10. High yield isolation of BMP-2 (show BMP2 Antibodies) from bone and in vivo activity of a combination of BMP-2 (show BMP2 Antibodies)/TGF-beta1.

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 stimulated lubricin (show PRG4 Antibodies) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (show PRG4 Antibodies) much higher compared with twice-a-week treatment.

2. hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Antibodies)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (show MME Antibodies)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

3. TGF-beta1 modulates the expression of syndecan-4 (show SDC4 Antibodies) in cultured vascular endothelial cells in a biphasic manner.

4. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (show FGF2 Antibodies) expression through the activation of AP-1 (show JUN Antibodies) and NF-kappaB (show NFKB1 Antibodies) in bovine mammary gland fibroblasts.

5. The results identify TGFB1 and ESRRA (show ESRRA Antibodies) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

6. the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Antibodies) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Antibodies) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Antibodies) secretion.

7. Tenascin-X (show TNXB Antibodies) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

9. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data suggest that the interplay between cell-matrix adhesion and intercellular adhesion is an important determinant for some aspects of TGFbeta1-induced epithelial-mesenchymal transition via alphaSMA (show ACTA2 Antibodies) expression induction.

2. Excessive activation of TGFbeta by spinal instability causes vertebral endplate sclerosis and intervertebral disk degeneration.

3. study reveals a critical mechanism by which TGFbeta controls TH17 cell differentiation and uncovers the SKI (show SKI Antibodies)-SMAD4 (show SMAD4 Antibodies) axis as a potential therapeutic target for treating TH17-related diseases

4. A Smad3 (show SMAD3 Antibodies)-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-beta in mouse endometrium.

5. TGFss through the Alk1 (show ACVRL1 Antibodies)/TgfssR2 receptor axis is acting on endothelial cells to produce hematopoiesis.

6. The adoptive transfer of NK1.1(-) CD4 (show CD4 Antibodies)(+) NKG2D (show KLRK1 Antibodies)(+) cells suppressed DSS (show PMP22 Antibodies)-induced colitis largely dependent on TGF-beta. Thus, NK1.1(-) CD4 (show CD4 Antibodies)(+) NKG2D (show KLRK1 Antibodies)(+) cells exhibited immune regulatory functions, and this T cell subset could be developed to suppress inflammation in clinics.

7. The present study describes the ability of color-coded intravital imaging to demonstrate the efficacy of a TGF-beta inhibitor to target stroma in an orthotopic mouse model of pancreatic cancer.The present study describes the ability of color-coded intravital imaging to demonstrate the efficacy of a TGF-beta inhibitor to target stroma in an orthotopic mouse model of pancreatic cancer.

8. The ratio of full-length versus cleaved uPAR (show PLAUR Antibodies) as analysed by Western blotting and its regulation was assessed by addition of different protease inhibitors and transforming growth factor - beta1 (TGF-beta1). The role of uPAR (show PLAUR Antibodies) cleavage in cell proliferation and migration was analysed using real-time cell analysis and invasion was assessed using the myoma invasion model

9. Hepatic Stellate Cells express iron-transport proteins. Holotransferrin (iron) activates HSC (show FUT1 Antibodies) fibrogenesis and the TGF-beta pathway, whereas iron depletion by chelation reverses this, suggesting that this could be a useful adjunct therapy for patients with fibrosis.

10. The results show that lnc-Spry1 (show SPRY1 Antibodies) could act as an early mediator of TGF-beta signaling and reveal different roles for a long noncoding RNA in modulating transcriptional and posttranscriptional gene expression.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (show SMAD3 Antibodies) signaling pathway in chronic heart failure .

2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Antibodies), and the amelioration of disc degradation.

4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Antibodies) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

6. Smad7 (show SMAD7 Antibodies) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Antibodies) signaling target in limbal epithelial stem cells.

7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

8. After NOTCH1 (show NOTCH1 Antibodies) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Antibodies) and collagen II.

9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF beta is involved in the pathogenesis of tympanosclerosis.

2. There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Antibodies) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Within the limitations of the study design, production of COMP (show COMP Antibodies) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.