Browse our anti-TGFB1 (TGFB1) Antibodies

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. STAT3 (show STAT3 Antibodies) signaling is hyperactivated in systemic sclerosis in a TGFbeta-dependent manner

2. NOTCH1 (show NOTCH1 Antibodies) is a central mediator of TGFbetamediated FOXP3 (show FOXP3 Antibodies) expression and NOTCH1 (show NOTCH1 Antibodies) inhibition produces a significant reduction of melanoma cell proliferation and viability.

3. TET2 (show TET2 Antibodies) plays an important role in the pathogenesis of diabetic nephropathy by activating TGFbeta1 expression through demethylation of CpG islands in the TGFbeta1 regulatory region

4. Autocrine transforming growth factor-beta/activin (show Actbeta Antibodies) A (show INHBA Antibodies)-Smad (show SMAD1 Antibodies) signaling induces hepatic progenitor cells undergoing partial epithelial-mesenchymal transition states

5. epigallocatechin gallate and curcumin are potent in preventing Epithelial to mesenchymal transition induced by TGF-beta1 in ARPE-19 cells and therefore, proposed as potential molecules for further pre-clinical evaluation in Proliferative vitreoretinopathy management

6. TGFB1-mediated PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) and p38 MAP kinase (show MAPK14 Antibodies) dependent alternative splicing of fibronectin (show FN1 Antibodies) extra domain A in human podocyte culture has been reported.

7. TGFB1 polymorphisms -509 C>T and +10 T>C are associated with Chagas disease susceptibility in a Brazilian population.

8. S100A4 (show S100A4 Antibodies) expression is induced by the TGF-beta pathway.

9. the results of the present study indicated that miR2145p may promote the adipogenic differentiation of BMSCs through regulation of the TGFbeta/Smad2 (show SMAD2 Antibodies)/COL4A1 (show COL4A1 Antibodies) signaling pathway, and potentially may be used to develop a novel drug for postmenopausal osteoporosis.

10. these results indicate that miR124 transection inhibits the growth and aggressive of osteosarcoma, potentially via suppression of TGFbetamediated AKT (show AKT1 Antibodies)/GSK3beta/snail (show SNAI1 Antibodies) family transcriptional repressor 1 (SNAIL1 (show SNAI1 Antibodies)) signaling, suggesting miR124 may be a potential anticancer agent/target for osteosarcoma therapy.

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 stimulated lubricin (show PRG4 Antibodies) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (show PRG4 Antibodies) much higher compared with twice-a-week treatment.

2. hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Antibodies)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (show MME Antibodies)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

3. TGF-beta1 modulates the expression of syndecan-4 (show SDC4 Antibodies) in cultured vascular endothelial cells in a biphasic manner.

4. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (show FGF2 Antibodies) expression through the activation of AP-1 (show JUN Antibodies) and NF-kappaB (show NFKB1 Antibodies) in bovine mammary gland fibroblasts.

5. The results identify TGFB1 and ESRRA (show ESRRA Antibodies) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

6. the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Antibodies) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Antibodies) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Antibodies) secretion.

7. Tenascin-X (show TNXB Antibodies) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

9. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (show SMAD3 Antibodies) signaling pathway in chronic heart failure .

2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Antibodies), and the amelioration of disc degradation.

4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Antibodies) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

6. Smad7 (show SMAD7 Antibodies) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Antibodies) signaling target in limbal epithelial stem cells.

7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

8. After NOTCH1 (show NOTCH1 Antibodies) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Antibodies) and collagen II.

9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF beta is involved in the pathogenesis of tympanosclerosis.

2. There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Antibodies) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 regulated pAKT (show AKT1 Antibodies) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

2. SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Antibodies)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Antibodies) expression.

3. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Antibodies)+ T cells from mesentric lymph nodes.

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 is activated or inactivated by MMP20 or KLK4 (show KLK4 Antibodies) and that the amelogenin (show AMELX Antibodies) cleavage product is necessary for the in-solution mobility of TGF-beta1.

2. Activated TGF-beta signaling rescued miR (show MYLIP Antibodies)-143-reduced FSHR (show FSHR Antibodies) and intracellular signaling molecules, and miR (show MYLIP Antibodies)-143-induced porcine granulosa cell apoptosis.

3. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (show PTK2 Antibodies)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (show PTK2 Antibodies) signaling is inhibited.

4. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (show SMAD1 Antibodies) and MAPK (show MAPK1 Antibodies) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Antibodies) challenge

5. this study shows that anemonin may ameliorate LPS (show IRF6 Antibodies)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Antibodies) signaling pathways

6. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

7. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

8. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Antibodies), and IL-6 (show IL6 Antibodies) in ovarian follicles are reported.

9. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Antibodies) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

10. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Antibodies) signaling, reduces CFTR (show CFTR Antibodies) expression to impair CFTR (show CFTR Antibodies)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Antibodies) mutations and ultimately would compromise male fertility.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Antibodies) serves as a vegetally enriched, intrinsic factor (show GIF Antibodies) to ensure a prepared status of Smads for their activation.

3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Antibodies)

6. sortilin (show SORT1 Antibodies) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Within the limitations of the study design, production of COMP (show COMP Antibodies) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. RUNX1 (show RUNX1 Antibodies) promoted TGF-beta-induced partial EMT (show ITK Antibodies) by increasing transcription of the PI3K subunit p110delta, which mediated Akt (show AKT1 Antibodies) activation.

2. Transforming growth factor-beta1 induces cerebrovascular dysfunction and astrogliosis through angiotensin II type 1 receptor (show AGTR1 Antibodies)-mediated signaling pathways

3. TET2 (show TET2 Antibodies) plays an important role in the pathogenesis of diabetic nephropathy by activating TGFbeta1 expression through demethylation of CpG islands in the TGFbeta1 regulatory region

4. early myocardial CTGF (show CTGF Antibodies) mRNA expression (six hours) after Ang-II (show AGT Antibodies) exposure is likely dependent on latent TGF-beta activation via the canonical Smad (show SMAD1 Antibodies)-dependent pathway in resident cardiac cells.

5. These results indicate that the hepatocytic expression of TGF-beta and CTGF (show CTGF Antibodies) is mediated by Wnt (show WNT2 Antibodies) signalling in Schistosoma japonicum infection.

6. Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1, and MMP1 (show MMP1 Antibodies) in multinucleated macrophages.

7. type I and II IFN as in vivo modifiers of LIC fate that may significantly affect the impact of putative leukemia-driving activities such as the ETV6 (show ETV6 Antibodies)-RUNX1 (show RUNX1 Antibodies)-mediated growth advantage in the presence of TGF-beta and TLR4 (show TLR4 Antibodies)-upregulated mutagenic activity

8. Osthole,a natural coumarin, decreases the collagen/III ratio in transforming growth factor beta 1 (TGF-beta1)-transfected mouse cardiac fibroblasts via the TGF-beta/Smad (show SMAD1 Antibodies) signaling pathway.

9. both ERK (show EPHB2 Antibodies) and Smad2 (show SMAD2 Antibodies) signal pathways are involved in the activation of macrophages induced by TGF-b1 and high-ambient glucose, while there is no crosstalk shown in the process.

10. In obese mice, periodontitis caused the downregulation of MMP2 (show MMP2 Antibodies), and upregulation of TIMP1 (show TIMP1 Antibodies) and TGF-beta1 at transcriptional and translational levels

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Antibodies).

3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Antibodies) mediated pathway.

4. PCSK7 (show PCSK7 Antibodies) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

6. TGFbeta1 plays a role in zebrafish keratocyte migration.

7. data presented show that Zili (show PIWIL2 Antibodies) suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Antibodies) and preventing the formation of Smad2 (show SMAD2 Antibodies)/3/4 and Smad1 (show SMAD1 Antibodies)/5/9/4 complexes

8. TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Antibodies), 20beta-HSD (show HAL Antibodies) and membrane progestin receptor-beta (show PAQR8 Antibodies), to inhibit zebrafish oocyte maturation

9. These data suggest Pez (show PTPN14 Antibodies) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

10. Data show that Rock2 (show ROCK2 Antibodies) acts as a negative regulator of the TGFbeta signaling pathway.