Browse our anti-ATF6 (ATF6) Antibodies

Full name:: anti-Activating Transcription Factor 6 Antibodies (ATF6)

On www.antibodies-online.com are 175 Activating Transcription Factor 6 (ATF6) Antibodies from 28 different suppliers available. Additionally we are shipping ATF6 Kits (22) and ATF6 Proteins (11) and many more products for this protein. A total of 220 ATF6 products are currently listed.

Synonyms:: 9130025P16Rik, 9630036G24, AA789574, ATF-6-like, Atf6, ATF6A, Atf6alpha, ESTM49, GB16435

list all antibodies	Gene Name	GeneID	UniProt
	ATF6	22926	P18850
	ATF6	226641
	ATF6	304962
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anti-Human ATF6 Antibodies:

anti-Mouse (Murine) ATF6 Antibodies:

anti-Rat (Rattus) ATF6 Antibodies:

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Top referenced anti-ATF6 Antibodies

Hamster Monoclonal ATF6 Primary Antibody for FACS, IHC - ABIN2668920 : Donati, Imbriano, Mantovani: Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters. in Nucleic acids research 2006 (PubMed)
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Human Monoclonal ATF6 Primary Antibody for IP, WB - ABIN2451924 : Mori: Divest yourself of a preconceived idea: transcription factor ATF6 is not a soluble protein! in Molecular biology of the cell 2010 (PubMed)
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Human Monoclonal ATF6 Primary Antibody for IP, WB - ABIN2451923 : Yamamoto, Sato, Matsui, Sato, Okada, Yoshida, Harada, Mori: Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. in Developmental cell 2007 (PubMed)
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Human Polyclonal ATF6 Primary Antibody for IF (p), IHC (p) - ABIN732293 : Jiang, Ren, Jiang, Wang, Zhang, Yin, Wang, Qi, Wang, Feng: Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. in Neuroscience 2014 (PubMed)
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Human Polyclonal ATF6 Primary Antibody for ICC, ELISA - ABIN1001734 : Little, Ramakrishnan, Roy, Gazit, Lee: The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. in Critical reviews in eukaryotic gene expression 1995 (PubMed)
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Human Polyclonal ATF6 Primary Antibody for ICC, ELISA - ABIN1001735 : Liu, Kaufman: The unfolded protein response. in Journal of cell science 2003 (PubMed)
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Human Polyclonal ATF6 Primary Antibody for ICC, IF - ABIN4282032 : Boß, Newbatt, Gupta, Collins, Brüne, Namgaladze: AMPK-independent inhibition of human macrophage ER stress response by AICAR. in Scientific reports 2016 (PubMed)
Human Polyclonal ATF6 Primary Antibody for FACS, IHC (p) - ABIN652625 : Zhu, Johansen, Prywes: Interaction of ATF6 and serum response factor. in Molecular and cellular biology 1997 (PubMed)
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More Antibodies against ATF6 Interaction Partners

Human Activating Transcription Factor 6 (ATF6) interaction partners

Three branches of the Unfolded Protein Response (UPR) have been described, including the activation of the inositol-requiring enzyme 1 (IRE1 (show ERN1 Antibodies)), the pancreatic ER kinase (PKR (show PKLR Antibodies))-like ER kinase (PERK (show EIF2AK3 Antibodies)), and the activating transcription factor 6 (ATF6).
The expression of ASNS (show ASNS Antibodies) was significantly elevated when ATF6 was over expressed. The expressions of these 2 genes were both decreased in hepatocellular carcinoma (HCC (show FAM126A Antibodies))patients, and it was more significantly with ASNS (show ASNS Antibodies). The mRNA levels of ASNS (show ASNS Antibodies) and ATF6 were positively correlated with each other. rs34050735 was associated with HCC (show FAM126A Antibodies) in the case-control study and also an independent predictor of overall survival of HCC (show FAM126A Antibodies) patients.
Human ATF6 mutations interrupt distinct sequential steps of the ATF6 activation mechanism.
Findings indicate a central role for activating transcription factor 6 (ATF6alpha) in the establishment of morphological features of senescence in normal primary fibroblasts.
A novel homozygous c.1691A>G (p.(Asp564Gly)) ATF6 mutation was identified in two siblings with autosomal recessive cone-rod dystrophy.
This review shown that the achromatopsia arising from genetic mutations in Activating Transcription Factor 6 (ATF6).
In summary, our study revealed a negative regulation of the UPR transducer ATF6 through post-translational SUMOylation. The information from this study will not only increase our understanding of the fine-tuning regulation of the UPR signaling but will also be informative to the modulation of the UPR for therapeutic benefits.
Low ATF6 expression is associated with cancer.
Activating transcription factor 6 (ATF6alpha) pathway and ER-associated protein degradation (ERAD) are elevated in salivary glands of Sjogren's syndrome patients (SS).
A transcription factor complex consisting of ATF6 (an endoplasmic reticulum-resident factor) and C/EBP-beta (show CEBPB Antibodies) is required for the IFN-gamma-induced (show SAMHD1 Antibodies) expression of DAPK1 (show DAPK1 Antibodies) IFN-gamma-induced (show SAMHD1 Antibodies) proteolytic processing of ATF6 and phosphorylation of C/EBP-beta (show CEBPB Antibodies) are obligatory for the formation of this transcriptional complex

Mouse (Murine) Activating Transcription Factor 6 (ATF6) interaction partners

ATF6 is essential for ER stress-mediated SESN2 (show SESN2 Antibodies) induction.
Forced activation of the ATF6 UPR branch reduced infarct volume and improved functional outcome at 24 h after stroke
However, depletion of XBP1 (show XBP1 Antibodies) and ATF6, alone or in combination, prevented autophagy induction and significantly enhanced Japanese encephalitis virus-induced cell death.
Deletion of Atf6alpha suppressed inflammation, and ameliorated demyelination after experimental autoimmune encephalomyelitis.
we show that overexpression of the dominant-negative form of ATF6 (dnATF6) increases susceptibility to develop hepatic steatosis in diet-induced insulin (show INS Antibodies)-resistant mice and fasted mice. Furthermore, hepatic overexpression of the active form of ATF6 promotes hepatic fatty acid oxidation and protects against hepatic steatosis in diet-induced insulin (show INS Antibodies)-resistant mice.
The present study extends our understanding and provides new insights into the physiological significance of ATF6, a key signal transducer of ER stress, in ovarian granulosa cells.
ATF6 serves as an important role between ER stress and oxidative stress, by decreasing myocardial ischemia/reperfusion damage.
ATF6alpha mRNA and protein levels were higher in the uterus near the implantation site following embryo implantation.
ATF6a favorably controls chondrogenesis and bone formation (1) by acting as a co-factor of Runx2 and enhancing Runx2-incited hypertrophic chondrocyte differentiation, and (2) by affecting IHH and PTHrP signaling.
Data show that EIF2AK3/PERK (show EIF2AK3 Antibodies)-mediated downregulation of miR (show MLXIP Antibodies)-424(322)-503 cluster regulates optimal activation of IRE1 (show ERN1 Antibodies) protein and activating transcription factor 6 (ATF6) during conditions of endoplasmic reticulum stress.

Cow (Bovine) Activating Transcription Factor 6 (ATF6) interaction partners

Exposure of endothelial cells to VEGF (show VEGFA Antibodies), high glucose, or hydrogen peroxide up-regulated the XBP1 (show XBP1 Antibodies)/IRE1 alpha (show ERN1 Antibodies) and ATF6 arms of the unfolded protein response compared with untreated cells.

ATF6 Antigen Profile

Antigen Summary

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Alternative names and synonyms associated with ATF6

activating transcription factor 6 (ATF6) antibody
uncharacterized LOC412432 (LOC412432) antibody
activating transcription factor 6 S homeolog (atf6.S) antibody
cyclic AMP-dependent transcription factor ATF-6 alpha (LOC100122162) antibody
activating transcription factor 6 (Atf6) antibody

9130025P16Rik antibody
9630036G24 antibody
AA789574 antibody
ATF-6-like antibody
Atf6 antibody
ATF6A antibody
Atf6alpha antibody
ESTM49 antibody
GB16435 antibody

Protein level used designations for ATF6

activating transcription factor 6 , cyclic AMP-dependent transcription factor ATF-6 alpha-like , cAMP-dependent transcription factor ATF-6 alpha , cyclic AMP-dependent transcription factor ATF-6 alpha

GENE ID	SPECIES
100051169	Equus caballus
412432	Apis mellifera
457461	Pan troglodytes
496056	Xenopus laevis
720056	Macaca mulatta
100122162	Nasonia vitripennis
100451142	Pongo abelii
22926	Homo sapiens
226641	Mus musculus
304962	Rattus norvegicus
100158076	Sus scrofa
530610	Bos taurus
100358536	Oryctolagus cuniculus
100730337	Cavia porcellus
488660	Canis lupus familiaris
424365	Gallus gallus
541606	Ovis aries

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