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anti-Human AGRP Antibodies:
anti-Mouse (Murine) AGRP Antibodies:
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AgRP is not associated with changes in hunger or satiety, and can change without corresponding changes in leptin (show LEP Antibodies). This suggests that AgRP may not be involved in the episodic control of appetite and the release of AgRP may involve signals other than leptin (show LEP Antibodies).
data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (show MC4R Antibodies)), pro-opiomelanocortin (POMC (show POMC Antibodies)), apolipoprotein E (APOE (show APOE Antibodies)) and agouti-related protein (AGRP) with obesity in the North Indian population.
CSF (show CSF2 Antibodies) AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects.
human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor (show MC4R Antibodies)
Variations in genes AGRP, CPE (show CPE Antibodies), GHRL (show GHRL Antibodies), GLP1R (show GLP1R Antibodies), HTR2A, NPY1R (show NPY1R Antibodies), NPY5R (show NPY5R Antibodies), SOCS3 (show SOCS3 Antibodies) and STAT3 (show STAT3 Antibodies) showed modest associations with BMI in European Americans.
Elevations in AgRP also favor the diagnosis of ectopic ACTH (show POMC Antibodies) syndrome, suggesting AgRP should be further evaluated as a potential neuroendocrine tumor marker.
AGRP SNP (rs1338993) was not associated with antipsychotic-induced weight gain in schizophrenia patients.
Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men.
Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin (show LEP Antibodies) concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance.
By using mutant mice with liver-specific ablation of Eralpha (show ESR1 Antibodies), the authors here demonstrate that the hepatic ERalpha (show ESR1 Antibodies) is essential for the modulation of the activity of Agouti Related Protein (AgRP) neurons in relation to the reproductive cycle and diet.
The results demonstrate a novel role of PDK1 (show PDPK1 Antibodies) in AgRP neurons to counteract the high salt diet-induced hypertension by preventing hyperactivation of paraventricular nucleus nesfatin-1 (show NUCB2 Antibodies) neurons.
The findings are consistent with the idea that, during metabolic deficiency, AgRP signaling contributes to infertility by inhibiting Kiss1 (show KISS1 Antibodies) neurons.
POMC (show POMC Antibodies) and AgRP neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1 (show KISS1 Antibodies)(ARC (show NOL3 Antibodies)) neurons in male mice
P2Y6 (show P2RY6 Antibodies) signaling in AgRP neurons is involved in the onset of obesity-associated hyperphagia.
These results identify SK3 (show KCNN3 Antibodies) as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY (show NPY Antibodies) neural activities and animals' feeding behavior and energy metabolism.
It was concluded that a small population of neuroendocrine cells in the adrenal medulla, and the arcuate nucleus of the hypothalamus, express AgRP and neuropeptide Y (show NPY Antibodies) and are functionally involved in the systemic response to fasting.
These findings indicate that the relevance of AgRP to POMC (show POMC Antibodies) neuron GABA connectivity depends on the state of AgRP neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
CRFR1 (show CRHR1 Antibodies), in a subset of AgRP neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP/NPY (show NPY Antibodies) neurons in mice.
(Nle4, d-Phe7)-alphaMSH (show POMC Antibodies) (NDP (show NDP Antibodies)-alphaMSH (show POMC Antibodies)) stimulated the production of cortisol and these effects were abolished by agouti related protein or SHU9119, a synthetic antagonist of melanocortin 3 and melanocortin 4 receptor (show MC4R Antibodies)
Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP (show NDP Antibodies)-alphaMSH (show POMC Antibodies)-induced cortisol production through its antagonistic properties towards MSH (show POMC Antibodies) at the level of MC4-R (show MC4R Antibodies)
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
, orexigenic neuropeptide
, agouti related protein
, agouti related protein homolog (mouse)