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FKBP1A Products

(FK506 Binding Protein 1A, 12kDa (FKBP1A))
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008].

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Featured FKBP1A Categories

FKBP1A Antibodies

High quality antibodies with extensive validation data.

FKBP1A ELISA Kits

Reliable ELISA kits for a wide range of species.

FKBP1A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FKBP1A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
  • (4)
Cat. No. ABIN560904
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN7162823
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC
Validations
  • (3)
Cat. No. ABIN7259707
Quantity 200 μL
Datasheet Datasheet

Recommended FKBP1A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955918
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955919
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6951130
Quantity 96 tests
Datasheet Datasheet

Recommended FKBP1A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (3)
  • (1)
Cat. No. ABIN1354116
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3133482
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2721207
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our FKBP1A products

Åström-Olsson, Li, Olofsson, Borén, Öhlin, Grip: "Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics." in: Biochemical and biophysical research communications, Vol. 422, Issue 4, pp. 732-8, (2012) (PubMed).

Biagiotti, Rossi, Bianchi, Giacomini, Pierigè, Serafini, Conaldi, Magnani: "Immunophilin-loaded erythrocytes as a new delivery strategy for immunosuppressive drugs." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 154, Issue 3, pp. 306-13, (2011) (PubMed).

Sitaraman, Chatterjee: "Protein-protein interactions: an application of Tus-Ter mediated protein microarray system." in: Methods in molecular biology (Clifton, N.J.), Vol. 723, pp. 185-200, (2011) (PubMed).

Madeira, Ohman, Nilsson, Sjögren, Andrén, Svenningsson: "Coupling surface plasmon resonance to mass spectrometry to discover novel protein-protein interactions." in: Nature protocols, Vol. 4, Issue 7, pp. 1023-37, (2009) (PubMed).

Gerard, Debyser, Desender, Baert, Brandt, Baekelandt, Engelborghs: "FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T." in: Journal of neurochemistry, Vol. 106, Issue 1, pp. 121-33, (2008) (PubMed).

Shor, Zhang, Toral-Barza, Lucas, Abraham, Gibbons, Yu: "A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis." in: Cancer research, Vol. 68, Issue 8, pp. 2934-43, (2008) (PubMed).

Nilsson, Sköld, Sjögren, Svensson, Pierson, Zhang, Caprioli, Buijs, Persson, Svenningsson, Andrén: "Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins." in: Journal of proteome research, Vol. 6, Issue 10, pp. 3952-61, (2007) (PubMed).

Chen, Liu, Massague: "Mechanism of TGFbeta receptor inhibition by FKBP12." in: The EMBO journal, Vol. 16, Issue 13, pp. 3866-76, (1997) (PubMed).

Wang, Donahoe, Zervos: "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12." in: Science (New York, N.Y.), Vol. 265, Issue 5172, pp. 674-6, (1994) (PubMed).

Flanagan, Corthésy, Bram, Crabtree: "Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A." in: Nature, Vol. 352, Issue 6338, pp. 803-7, (1991) (PubMed).

Synonyms and alternative names related to FKBP1A

FK506 binding protein 1a (Fkbp1a), FK506 binding protein 1A (FKBP1A), FK506-binding protein (Fkbp12), FK506-binding protein 12 (FKBP12), FK506 binding protein 1Aa (fkbp1aa), FK506 binding protein 1C (FKBP1C), FK506-binding protein (EHI_180160), FK506-binding protein 59 (LOC5573443), FK506-binding protein (Fkbp13), FK506 binding protein like (FKBPL), FK506 binding protein 1A L homeolog (fkbp1a.L), FK506 binding protein 1A (Fkbp1a), 12kDa, ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12, ATFKBP12, Bmfkbp13, fj02g10, FK506-binding protein 12, Fkbp, FKBP-1A, FKBP-12, Fkbp1, FKBP1, FKBP1A, FKBP1B, Fkbp2, FKBP12, Fkbp12, FKBP12-T1, FKBP12-T2, IMMUNOPHILIN, mFKBP1, mFKBP12, MSJ1.19, MSJ1_19, PKC12, PKCI2, PPIASE, Rotamase, wu:fj02g10, zgc:73373

Protein level used designations for FKBP1A

  • 12 kDa FK506-binding protein
  • 12 kDa FKBP
  • FK506 Binding Protein12-T1
  • FK506 binding protein12
  • FK506 binding protein12-T2
  • FK506-binding protein 1A
  • FKBP-12
  • FKBP-1A
  • FKBP12-Exip3
  • PPIase FKBP1A
  • calstabin-1
  • immunophilin FKBP12
  • peptidyl-prolyl cis-trans isomerase FKBP1A
  • rotamase
  • Immunophilin FKBP12
  • binding protein
  • FK506-binding protein
  • FK506-binding protein 1
  • FK506-binding protein 12
  • FK506-binding protein 1A (12kD)
  • FK506-binding protein, T-cell, 12-kD
  • calstabin 1
  • protein kinase C inhibitor 2
  • FK506 binding protein 1B, 12.6 kDa
  • FK506 binding protein 2 (13 kDa)
  • FK506-binding protein 1 (12kD)
  • FK506-binding protein 1a
  • FK506 binding protein 1A, 12kDa
  • fk506-binding protein
  • FK506-binding protein-like
  • FK 506-binding protein
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