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Very early onset inflammatory bowel disease is associated with IL-10RA mutation, usually with severe intestinal symptoms and significant extra-intestinal symptoms, as well as varied responses to conventional treatment. In our study, c.301C>T and c.537G>A are the most common mutations.
Compound heterozygous mutations in IL10RA combined with a complement factor properdin mutation in infantile-onset inflammatory bowel disease.
IL-10R expression and signaling are decreased in monocytes from patients with Crohn's disease.
IL10R signaling regulates TH17 polarization and T-cell proliferation in humans but is not required for the generation and in vitro suppression of Tregs. Therapies targeting the TH17 axis might be beneficial for IL10- and IL10R-deficient patients as a bridge to allogeneic hematopoietic stem cell transplantation.
This case report and case-control study explores the role of IL10RA and its deficiency in the development of the immune system and inflammatory bowel diseases.
We identified 32 compound heterozygous mutations and 9 homozygous mutations in IL10 receptor subunit alpha and 1 homozygous mutation in IL10 receptor subunit beta. Among these mutations, 10 novel mutations were identified, and 6 pathogenic mutations had been previously described. In patients with IL10 receptor subunit alpha mutations, c.301C>T (p.R101RW) and c.537 G>A (p.T179T) were the most common mutations.
these findings provide a novel mechanism by which microbial-derived butyrate promotes barrier through IL-10RA-dependent repression of claudin-2
Expression of IL10R subunits within the leukocyte population (CD45(+) cells) was significantly higher in primary brain tumors than in metastases.
This study showed that lack of association with schizophrenia was detected for IL10 and IL10RA single polymorphisms and haplotypes.
The IL-10RA rs9610 A allele was increased in rheumatoid arthritis (RA) patient group compared with control subjects. Interestingly, significant differences were detected both in the allele and genotype frequencies of rs9610 between anti-CCP (anti-cyclic citrullinated peptide) positive patients and anti-CCP negative patients. The findings suggest that IL-10RA rs9610 polymorphism might contribute to RA susceptibility.
The quantitative methods used in this study have shown non-altered expression levels of different microglial markers (Iba-1, Cd11b and CD68), together with increased expression of IL6, IL10RA, colony stimulating factor 3 receptor and toll-like receptor 7 in the thalamus in FFI, which explains the seemingly contradictory results of the previous studies.
These results suggest that S138G loss-of-function polymorphism of the IL-10R1 may be important risk factor in increasing susceptibility to multiple sclerosis.
Results reveal the structure of box1 from class II cytokine receptors IFNLR1 and IL10RA bound to the FERM-SH2 domain of human JAK1, identifying a consensus motif for JAK1 interaction.
Interleukin 10 and interleukin 10 receptor expression was also enriched in interferon gamma-expressing activated CD8(+) T cells. Treatment of anti-CD3/CD28-stimulated, purified CD8(+) T cells with interleukin 10 alone could significantly enhance CD8(+) T cell survival, an effect dependent on interleukin 10 receptor expression
a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma.
results suggest that IL10-mediated inhibition of autophagy is facilitated by the cross talk between STAT3, AKT, and mTOR; in other words, the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways.
genetic association study in cohort of infants/children: Data suggest perianal fistulas are exhibited in patients with very early-onset inflammatory bowel disease with IL10 receptor mutations (IL10RA/B); prognosis and response to treatment are poor.
IL-10Ralpha expression is post-transcriptionally regulated by miR-15a, miR-185, and miR-211 in melanoma
We also observed that BM-MSCs upregulated IL-10 secretion as well as the expression of its receptor CD210 on T cells, thus creating a loop favoring the expansion of IL-10-producing T cells
SNP3 polymorphism is associated with myocardial infarction; may generate some conformational rearrangements of the IL-10R1 receptor domain which affects IL-10 complex binding and alters its downstream signal
In summary, our data identify the IL-10Ra on Tregs as a crucial component for control of Th17 immunity during homeostasis and after induction of acute GN.
These results indicate that IL10R-mediated regulation of macrophage function during the early postnatal period is indispensable for preventing the development of murine colitis.
cross-talk between type I IFN and IL-10R signaling pathways may represent a key host cellular mechanism to investigate further in order to unravel the balance between pathogenic inflammation and homeostasis of the colon. Taken together, our data clearly demonstrate that type I IFN signaling is pathogenic in S. typhimurium colitis
this study shows that the upregulation of IL-10Ra by STAT3 contributed to the suppressive function of dendritic cellss following histone deacetylase inhibition
The investigation of the IL-10R complex revealed that both the extracellular and intracellular domains of IL-10R2 influence the conformation of IL-10R1 and that both domains were required for transducing IL-10 signals.
ablation of IL-10 signaling in Th2 cells led to enhanced Th2 cell survival and exacerbated pulmonary inflammation in a murine model of house dust mite allergy
TR1 cell regulatory activity is dependent on IL-10 receptor signaling.
loss of IL-10R signaling impaired the generation and function of anti-inflammatory intestinal and bone-marrow-derived macrophages and their ability to secrete IL-10.
loss of IL-10 receptor expression impaired the critical conditioning of monocyte-derived macrophages and resulted in spontaneous development of severe colitis.
Recent findings review how IL10- and IL10R-dependent signaling modulates innate and adaptive immune responses in the murine intestine.
Treatment of mice with rIFN-gamma was sufficient to drive expression of IL-10R1 in the colonic epithelium. Intestinal epithelial-specific IL-10R1-null mice were more susceptible to DSS colitis associated with increased intestinal permeability.
Inhibition of IL-10R signaling during bacillus Calmette-Guerin (BCG) vaccination increases and balances IFN-gamma and IL-17A responses in favor of the host.
IL-10R subunit-alpha signaling plays a key role in the development as well as B-cell help function of T (follicular helper) cells in vitro and in vivo.
IL-10R blockade during chronic schistosomiasis mansoni results in the loss of B cells from the liver and the development of severe pulmonary disease.
showed here that IL-17A-producing CD4+ T cells expressed interleukin-10 receptor alpha (IL-10Ralpha) in vivo
Data show that, in an IL-10-dependent LPS model of endotoxemia, dampening of the immune response requires expression of IL-10R1 in monocytes/macrophages and/or neutrophils but not in T cells nor B cells.
reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody
Immunocytochemistry data shows that the region of the adrenal gland responsible for the vast majority of corticosterone synthesis, the zona fasciculata, predominantly expresses the IL-10 receptor 1.
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
interleukin 10 receptor 1
, interleukin-10 receptor subunit alpha
, interleukin 10 receptor, alpha
, interleukin-10 receptor subunit alpha-like
, IL-10 receptor subunit alpha
, IL-10R subunit 1
, IL-10R subunit alpha
, interleukin-10 receptor alpha chain
, interleukin-10 receptor subunit 1