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anti-Human Stanniocalcin 1 Antibodies:
anti-Mouse (Murine) Stanniocalcin 1 Antibodies:
anti-Rat (Rattus) Stanniocalcin 1 Antibodies:
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Human Monoclonal Stanniocalcin 1 Primary Antibody for ELISA, WB - ABIN563043
dos Santos, Trindade, Gonçalves, Bressan, Anastassopoulos, Yunes, Kobarg: Human stanniocalcin-1 interacts with nuclear and cytoplasmic proteins and acts as a SUMO E3 ligase. in Molecular bioSystems 2010
Cow (Bovine) Polyclonal Stanniocalcin 1 Primary Antibody for WB - ABIN2777144
Gao, Xu, Chen, Wang, Wang, Wu, Yuan: Potential protein toxicity of synthetic pigments: binding of poncean S to human serum albumin. in Biophysical journal 2008
Show all 2 Pubmed References
Human Polyclonal Stanniocalcin 1 Primary Antibody for IHC (p), WB - ABIN4892215
Hayase, Sasaki, Matsubara, Seo, Miyakoshi, Murata, Ozaki, Kakudo, Kumamoto, Ylaya, Cheng, Thorgeirsson, Hewitt, Ward, Kimura: Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells. in Thyroid : official journal of the American Thyroid Association 2015
these data demonstrated that STC1 can promote cell apoptosis via NF-kappaB (show NFKB1 Antibodies) phospho-P65 (show GORASP1 Antibodies) (Ser536) by PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies), IkappaBalpha (show NFKBIA Antibodies) and IKK (show CHUK Antibodies) signaling in cervical cancer cells
Our results demonstrated the contrasting effects of STC1 and STC2 (show STC2 Antibodies)-derived peptides on human macrophage foam cell formation associated with ACAT1 (show ACAT1 Antibodies) expression and on HASMC migration.
Ssecretory STC1 enhances metastatic potential of hepatocellular carcinomas via JNK (show MAPK8 Antibodies) signaling.
Glycolysis from glucose is regulated by hSTC-1, decreasing the adequate supply of glycerol-3-phosphate (G3P) needed for fatty acid esterification and triacylglycerol (TG) storage in brown adipose tissue (BAT (show BAAT Antibodies)). The decrease of TG capacity synthesis from glucose by hSTC-1 compromises the BAT (show BAAT Antibodies) thermogenic capacity.
Increased STC1 plasma level represents a hallmark of late-onset preeclampsia; STC1 gene variants modulate placental gene expression and maternal hormone levels.
Latanoprost-induced reduction of intraocular pressure is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties.
Study demonstrates that STC1 is overexpressed in the prostate carcinoma cell lines and suggests that it promotes prostate carcinoma cell proliferation via cyclin E1 (show CCNE1 Antibodies)/CDK2 (show CDK2 Antibodies).
In the fed state, STC1 increases the incorporation of (14)C from glucose into lipids in the white retroperitoneal adipose tissue (WRAT). STC1 is one of the hormonal factors that control glucose metabolism in WRAT in the fed state.
STC1 protein is significantly up-regulated in midsecretory endometrial fluid and is dysregulated in eutopic endometrial tissue from women with endometriosis. It is likely regulated by cAMP and may be involved in the pathogenesis of decidualization defects.
STC1 expression is significantly upregulated in human masticatory mucosa during wound healing
STC-1 maybe improve anti-inflammation, anti-oxidant and anti-apoptosis activities by affecting reactive oxygen species -mediated pathways, especially the phospho-modifications of the respective proteins, resulting in the increase of Superoxide dismutase (show SOD1 Antibodies) and reduce of capase-3, p53 (show TP53 Antibodies), IL-6 (show IL6 Antibodies) and IFN-gamma (show IFNG Antibodies).
STC1 blunts bleomycin-induced rise in thrombin protein and activity, diminishes thrombin (show F2 Antibodies)-induced signaling through PAR1 (show F2R Antibodies) to ERK (show EPHB2 Antibodies), and inhibits bleomycin-induced pneumonitis.
Stanniocalcin 1 is expressed in thyroid side population cells and thyroid cancer cells.
Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using Stc1.
Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase (show PRKAA2 Antibodies)-dependent pathway.
STC1 is an endogenous stress protein that may counteract LPS (show TLR4 Antibodies)-induced lung injury by inhibiting the inflammatory cascade and inducing antioxidant and antiapoptotic mechanisms.
Remarkably, X-linked genes are not overexpressed in female Stc1(-/-) mice, revealing the existence of a mechanism(s) that can compensate for a persistent XCI deficiency to regulate X-linked gene expression.
Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury.
STC1 was not crucial for the development of ischemic tolerance triggered by hypoxic preconditioning, or for preserving blood-brain barrier integrity but may be involved in functional recovery after stroke.
Over-expression of STC-1 up-regulated Bcl-2 (show BCL2 Antibodies) protein expression and slightly down-regulated caspase-3 (show CASP3 Antibodies) production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.
theca cell-derived big STC is targeted to the cholesterol/lipid storage droplets of luteal cells to regulate steroidogenesis.
once removed from their normal context within the ovary, luteal cells are capable of synthesizing and secreting big STC.
STC-1 in milk is increased following milk stasis
Stanniocalcin 1 downregulation is responsible for sorafenib-induced cardiotoxicity through activated ROS (show ROS1 Antibodies) generation.
the results suggest that the CaSR is critical for Ca(2+) homeostasis in larval zebrafish exposed to low environmental Ca(2+) levels, possibly owing to its modulation of stanniocalcin mRNA expression.
This study showed that stanniocalcin 1 (stc1)modulates cation levels in trpm7 (show TRPM7 Antibodies) mutants and in the wild type; levels of cations are restored to normal in trpm7 (show TRPM7 Antibodies) mutants when stc1 activity is blocked.
The temporal and cell type-specific expression of STC1 makes this gene a unique marker for implantation in pigs.
The effect of STC1 on the steroidogenetic pathway in cultured granulosa cells is reported.
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.
, stanniocalcin 1