Browse our anti-Stanniocalcin 1 (STC1) Antibodies

Human Stanniocalcin 1 (STC1) interaction partners

1. High serum levels of osteopontin, stanniocalcin-1 and FGF 23 at the time of surgery are important prognostic factors in renal cell carcinoma

2. CAPG competes with the transcriptional repressor arginine methyltransferase 5 (PRMT5) for binding to the STC-1 promoter.

3. STC1 may serve an oncogenic role in hypoxic GC via dysregulating Bcl2.

4. these results suggest that mesenchymal stem cells protect vascular cells from inflammatory injury partially by secreting STC1

5. Data indicate that stanniocalcin 1 (STC1) is a non-canonical NOTCH1 ligand and acts as a crucial regulator of stemness in glioblastoma (GBM).

6. these data demonstrated that STC1 can promote cell apoptosis via NF-kappaB phospho-P65 (Ser536) by PI3K/AKT, IkappaBalpha and IKK signaling in cervical cancer cells

7. Our results demonstrated the contrasting effects of STC1 and STC2-derived peptides on human macrophage foam cell formation associated with ACAT1 expression and on HASMC migration.

8. Ssecretory STC1 enhances metastatic potential of hepatocellular carcinomas via JNK signaling.

9. Glycolysis from glucose is regulated by hSTC-1, decreasing the adequate supply of glycerol-3-phosphate (G3P) needed for fatty acid esterification and triacylglycerol (TG) storage in brown adipose tissue (BAT). The decrease of TG capacity synthesis from glucose by hSTC-1 compromises the BAT thermogenic capacity.

10. Increased STC1 plasma level represents a hallmark of late-onset preeclampsia; STC1 gene variants modulate placental gene expression and maternal hormone levels.

11. Latanoprost-induced reduction of intraocular pressure is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties.

12. Study demonstrates that STC1 is overexpressed in the prostate carcinoma cell lines and suggests that it promotes prostate carcinoma cell proliferation via cyclin E1/CDK2.

13. In the fed state, STC1 increases the incorporation of (14)C from glucose into lipids in the white retroperitoneal adipose tissue (WRAT). STC1 is one of the hormonal factors that control glucose metabolism in WRAT in the fed state.

14. STC1 protein is significantly up-regulated in midsecretory endometrial fluid and is dysregulated in eutopic endometrial tissue from women with endometriosis. It is likely regulated by cAMP and may be involved in the pathogenesis of decidualization defects.

15. STC1 expression is significantly upregulated in human masticatory mucosa during wound healing

16. elevated STC-1 expression is associated with poor clinical outcome in triple-negative breast cancer (TNBC) patients, and STC-1 is directly involved in the invasiveness of TNBC cells

17. we demonstrated that aberrant STC1 expression is associated with poor prognosis and stimulates the invasiveness of triplenegative breast cancer cells

18. our findings strongly suggest that elevated expression of STC1 protein at the III-IV stage of lung adenocarcinoma promotes tumorigenesis of lung adenocarcinoma and positively associates with the cancer progression, which may be of potential value as tumor marker in clinical tracking lung adenocarcinoma progression.

19. Data suggest that stanniocalcin 1 and 2 (STC1, STC2) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) during folliculogenesis.

20. STC1 gene expression at diagnosis might be a useful prognostic marker for clinical outcome and monitoring therapeutic response in patients with acute leukemia.

Mouse (Murine) Stanniocalcin 1 (STC1) interaction partners

1. Latanoprost-induced reduction of intraocular pressure is mediated through the downstream signaling molecule STC-1. When used by itself, STC-1 exhibits ocular hypotensive properties.

2. STC-1 maybe improve anti-inflammation, anti-oxidant and anti-apoptosis activities by affecting reactive oxygen species -mediated pathways, especially the phospho-modifications of the respective proteins, resulting in the increase of Superoxide dismutase and reduce of capase-3, p53, IL-6 and IFN-gamma.

3. STC1 blunts bleomycin-induced rise in thrombin protein and activity, diminishes thrombin-induced signaling through PAR1 to ERK, and inhibits bleomycin-induced pneumonitis.

4. Stanniocalcin 1 is expressed in thyroid side population cells and thyroid cancer cells.

5. Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using Stc1.

6. Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway.

7. STC1 is an endogenous stress protein that may counteract LPS-induced lung injury by inhibiting the inflammatory cascade and inducing antioxidant and antiapoptotic mechanisms.

8. critical for kidney tubular epithelial survival under physiologic conditions

9. Remarkably, X-linked genes are not overexpressed in female Stc1(-/-) mice, revealing the existence of a mechanism(s) that can compensate for a persistent XCI deficiency to regulate X-linked gene expression.

10. Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury.

11. STC1 was not crucial for the development of ischemic tolerance triggered by hypoxic preconditioning, or for preserving blood-brain barrier integrity but may be involved in functional recovery after stroke.

12. the inner medullary STC-1 gene is differentially regulated in rat and mouse by arginine vasopressin and angiotensin II

13. Vascular endothelial growth factor-D stimulates endothelial cell VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects.

14. STC-1 could have a role in salt and water balance as dehydration necessitates water conservation as well as controlled natriuresis and kaliuresis.

15. the biological repertoires of STCs in mammals will be considerably larger than in fish and may not be limited to mineral metabolism

16. STC1 is expressed in a time- and cell-specific manner and may play an autocrine/paracrine role during osteoblast development and bone formation

17. STC-1 can affect calcium homeostasis, bone and muscle mass and structure, and angiogenesis

18. Data characterize the STC receptor and the functional targeting of ligand and receptor to mitochondria.

19. STC1 may play a selective modulatory role in angiogenesis, possibly serving as a "stop signal" or stabilizing factor contributing to the maturation of newly formed blood vessels

20. role for mammalian STC1 in modulating the immune/inflammatory response in ureteric obstruction

Cow (Bovine) Stanniocalcin 1 (STC1) interaction partners

1. Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism.

2. theca cell-derived big STC is targeted to the cholesterol/lipid storage droplets of luteal cells to regulate steroidogenesis.

3. once removed from their normal context within the ovary, luteal cells are capable of synthesizing and secreting big STC.

4. STC-1 in milk is increased following milk stasis

Zebrafish Stanniocalcin 1 (STC1) interaction partners

1. Stanniocalcin 1 downregulation is responsible for sorafenib-induced cardiotoxicity through activated ROS generation.

2. the results suggest that the CaSR is critical for Ca(2+) homeostasis in larval zebrafish exposed to low environmental Ca(2+) levels, possibly owing to its modulation of stanniocalcin mRNA expression.

3. This study showed that stanniocalcin 1 (stc1)modulates cation levels in trpm7 mutants and in the wild type; levels of cations are restored to normal in trpm7 mutants when stc1 activity is blocked.

Pig (Porcine) Stanniocalcin 1 (STC1) interaction partners

1. The temporal and cell type-specific expression of STC1 makes this gene a unique marker for implantation in pigs.

2. The effect of STC1 on the steroidogenetic pathway in cultured granulosa cells is reported.