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Polyclonal AGPAT6 Primary Antibody for WB - ABIN540790
Vergnes, Beigneux, Davis, Watkins, Young, Reue: Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. in Journal of lipid research 2006
Show all 2 Pubmed References
Polyclonal AGPAT6 Primary Antibody for WB - ABIN540791
Beigneux, Vergnes, Qiao, Quatela, Davis, Watkins, Coleman, Walzem, Philips, Reue, Young: Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. in Journal of lipid research 2006
Show all 2 Pubmed References
Human Polyclonal AGPAT6 Primary Antibody for WB - ABIN250786
Masuda, Miyazaki-Anzai, Keenan, Okamura, Kendrick, Chonchol, Offermanns, Ntambi, Kuro-O, Miyazaki: Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity. in The Journal of clinical investigation 2015
None of the eleven AGPAT6 variants were robustly associated with type 2 diabetes in the Danish.
Results reveal a link between the lipogenic effects of insulin (show INS Antibodies) and microsomal GPAT3 (show AGPAT9 Antibodies) and GPAT4, implying their importance in glycerolipid biosynthesis.
AGPAT6 is a microsomal GPAT (show PPAT Antibodies), and we propose renaming this enzyme GPAT4.
Variants affecting the expression of AGPAT6 are causally involved in differential milk fat synthesis, with pleiotropic consequences for a diverse range of other milk components.
The results of this study suggest that suggest that SLC27A6 (show SLC27A6 Antibodies), ACSL1 (show Acsl1 Antibodies), FABP3 (show FABP3 Antibodies), AGPAT6, and LPIN1 (show LPIN1 Antibodies) coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.
These data identify SEIPIN as an evolutionarily conserved regulator of microsomal GPAT.
GPAT4 limits excessive fatty acid oxidation and the detrimental induction of a hypermetabolic state
Data (from studies in knockout mice) suggest GPAT4-derived phosphatidic acid impairs insulin (show INS Antibodies) signaling in liver/contributes to insulin (show INS Antibodies) resistance via interaction of mTOR (mechanistic target of rapamycin (show FRAP1 Antibodies))/Rictor (show RICTOR Antibodies) (RPTOR (show RPTOR Antibodies) independent companion of mTOR (show FRAP1 Antibodies)).
GPAT1 (show GPAM Antibodies), but not GPAT4, is required to incorporate de novo synthesized fatty acids into TAG and to divert them away from oxidation.
Glycerol-3-phosphate acyltransferase 4 might play an important role in spermatogenesis, especially in mid-meiosis.[Glycerol-3-phosphate acyltransferase 4]
Expression in testis increased steadily with spermatogenesis & sexual maturation. It may play an important role in spermatogenesis & development of cryptorchid testes, & is testis-specific (show AIF1 Antibodies) apoptosis candidate oncogene (show RAB1A Antibodies)
Results show that Agpat6 plays a unique role in determining triglyceride content and composition in adipose tissue and liver that cannot be compensated by other members of the Agpat family.
Results identify a novel glycerolipid acyltransferase of the endoplasmic reticulum, AGPAT6, which is crucial for the production of milk fat by the mammary gland.
"Agpat6(-/-) mice" are actually deficient in a novel NEM-sensitive sn-Glycerol-3-phosphate acyltransferase (GPAT), GPAT4
AGPAT6 is a microsomal GPAT (show GPAM Antibodies), and we propose renaming this enzyme GPAT4.
GPAT6 is important for tapetum development and plays multiple roles in plant fertility.
Lysophosphatidic acid acyltransferases (EC 188.8.131.52) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.
1-AGP acyltransferase 6
, 1-acyl-sn-glycerol-3-phosphate acyltransferase zeta
, 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
, glycerol-3-phosphate acyltransferase 6
, lysophosphatidic acid acyltransferase zeta
, testis spermatogenesis apoptosis-related protein 7
, putative lysophosphatidic acid acyltransferase
, 1-AGPAT 6
, acyl-CoA:glycerol-3-phosphate acyltransferase 4
, glycerol-3-phosphate acyltransferase 4
, 1-acylglycerol-3-phosphate O-acyltransferase 6