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Human Polyclonal CDK16 Primary Antibody for IHC, IHC (p) - ABIN4344223
Yanagi, Krajewska, Matsuzawa, Reed: PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells. in Cancer research 2014
Show all 3 Pubmed References
Human Polyclonal CDK16 Primary Antibody for ELISA, WB - ABIN543684
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
CDK16 negatively modulates p53 signaling pathway to promote radioresistance in lung cancer cells.
CDK16 is significantly up-regulated in non-small cell lung cancer tumor tissue and plays a role in promoting cell proliferation.
PCTAIRE1 has a role in regulating p27, c-Myc levels and tumor growth in cutaneous cutaneous squamous cell carcinoma cells
CDK-16 upregulation in serous EOC cells may represent a negative feedback loop to promote ovarian cell differentiation in malignantly-transformed serous epithelial ovarian cancer cells
GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC
Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3.
PCTK1 in the proliferation and survival of medulloblastoma characterized by cMYC amplification
PCTK1 regulates spindle orientation through phosphorylation of Ser83 on KAP0, a regulatory subunit of protein kinase A.
An unexpected role for PCTAIRE1 in regulating p27 stability, mitosis, and tumor growth.
Dysfunction of MKL2 and its transcriptional coactivation partner, serum response factor (SRF), was supported by a decrease in gene and protein expression of PCTAIRE1, a downstream target of MKL2:SRF heterodimer transcriptional activation
Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis
a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.
CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site.
Cdk5-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development
Data show that various forms of PCTAIRE-1 transfected into neuroblastoma cell lines could either promote or inhibit neurite outgrowth, suggesting a potential role for the PCTAIRE-1 gene product in the control of neurite outgrowth.
Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein
CCNYL1 regulates spermatogenesis through the interaction and modulation of CDK16.
Mice lacking CDK16 developed normally, but male mice were infertile. Spermatozoa isolated from their epididymis displayed thinning and elongation of the annulus region, adopted a bent shape, and showed impaired motility.
findings demonstrate that Pctaire1 interacts with p35, both in vitro and in vivo, and that phosphorylation of Pctaire1 by Cdk5 enhances its kinase activity
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells\; in exocytosis\; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
PCTAIRE-motif protein kinase 1
, cell division protein kinase 16
, serine/threonine-protein kinase PCTAIRE-1
, PCTAIRE protein kinase 1
, PCTAIRE-1 protein kinase, alternatively spliced
, cyclin-dependent kinase 16