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anti-Human CRHR1 Antibodies:
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Human Polyclonal CRHR1 Primary Antibody for ICC, IF - ABIN314277
Xu, Rabadan-Diehl, Nikodemova, Wynn, Spiess, Aguilera: Inhibition of corticotropin releasing hormone type-1 receptor translation by an upstream AUG triplet in the 5' untranslated region. in Molecular pharmacology 2001
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Human Polyclonal CRHR1 Primary Antibody for IHC (p) - ABIN4300460
Lemos, Wanat, Smith, Reyes, Hollon, Van Bockstaele, Chavkin, Phillips: Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. in Nature 2012
Show all 2 Pubmed References
Human Polyclonal CRHR1 Primary Antibody for ELISA, WB - ABIN238557
Rissman, Lee, Vale, Sawchenko: Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
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Mouse (Murine) Polyclonal CRHR1 Primary Antibody for ELISA - ABIN188718
Ungless, Singh, Crowder, Yaka, Ron, Bonci: Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. in Neuron 2003
Human Polyclonal CRHR1 Primary Antibody for IF, ELISA - ABIN1535580
Kageyama, Hasegawa, Akimoto, Yamagata, Tamasawa, Suda: Differential regulation of gonadotropin-releasing hormone by corticotropin-releasing factor family peptides in hypothalamic N39 cells. in Peptides 2011
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Significantly higher CRF1 and CRF2 receptor (show CRHR2 Antibodies) levels after CNS sensitization were detected in the Hippocampus.
found no differences in genotype distributions between heroin-dependent subjects and controls. However, identified a prominent interaction of one variant of the CRHBP (show CRHBP Antibodies) gene predicting the risk of heroin relapse in the chronically stressed subjects.
The large scale refinement of transmembrane helices of the CRFR1 homology model resulted in the significant improvement of its accuracy with respect to the crystal structure of CRFR1, especially in the binding site area.
Data suggest that corticotrophin-releasing hormone (CRH (show CRH Antibodies)) is able to stimulate copeptin (show AVP Antibodies) release in healthy controls suggesting direct interaction of CRH/CRH (show CRH Antibodies)-receptor signaling and vasopressin (show AVP Antibodies); these interactions appear to be altered in patients with pituitary disease; copeptin (show AVP Antibodies) may be serum biomarker of altered CRH/CRH (show CRH Antibodies)-receptor signaling in pituitary diseases.
The negative and positive inputs are integrated by hypoxic initiation and duration in CRHR1 transcription.
This study suggests that SNPs in the CRHR1 gene may influence BDNF (show BDNF Antibodies) levels in crack cocaine addiction.
found an interaction between CRHR1 Single Nucleotide Polymorphisms and maternal depression, with the homozygous minor genotype acting as a protective factor against brooding in the presence of maternal depression.
The results reveal that specific CRHR1 polymorphisms moderate the effect of Early life stress on emotional empathy.
A significant increase in CRH (show CRH Antibodies) and CRHR-1 expression was significantly correlated with psychological stress in vitiligo (show MITF Antibodies).
The present study identified a potential role of CRHR1 hypomethylation - conferring increased CRHR1 expression - in panic disorder and a related dimensional intermediate phenotype.
Expression of Crhr1 is decreased in the pituitary gland of corticotropin-releasing hormone (show CRH Antibodies) knock-out mice exposed to repeat stress.
CRF-R1 expression levels were proportional to the severity of DSS (show PMP22 Antibodies)-induced colitis. Activation of CRF-R1 aggravated inflammation, and inhibition of CRF-R1 ameliorates inflammation evaluated by the DAI (show ZBP1 Antibodies) and histological scores in the colon samples of the DSS (show PMP22 Antibodies)-treated mice.
report a sexually dimorphic expression of CRFR1 within the rostral portion of the anteroventral periventricular nucleus of the hypothalamus
These results revealed a prominent role for CRF1 signaling in mast cells as a positive modulator of stimuli-induced degranulation.
switch in G protein coupling for type 1 corticotropin-releasing factor (show CRH Antibodies) receptors promotes excitability in epileptic brains
Study characterized the influences of early-life stress on the developmental trajectory of hippocampal pyramidal neurons, and highlighted the critical role of CRHR1 in modulating these negative outcomes evoked by early-life stress.
the beneficial effects of CRFR1 antagonism seen in transgenic mice may be mechanistically linked to the modulation of oxidative stress pathways
CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the elevated plus maze.
found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Excitability of genetically isolated CRF (show CRH Antibodies)-receptive (CRFR1) neurons in the central nucleus of the amygdala (CeA (show CEA Antibodies)) is potently enhanced by CRF (show CRH Antibodies) and that CRFR1 signaling in the CeA (show CEA Antibodies) is critical for discriminative fear
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN (show UCN Antibodies), CRHR1 and CRHR2 (show CRHR2 Antibodies) and that UCN (show UCN Antibodies) plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 and CRHR2 (show CRHR2 Antibodies) are expressed in the bovine adrenal gland.
results indicate that arginine vasopressin (show AVP Antibodies) receptor V3 and corticotropin-releasing factor receptor 1 mRNAs are coordinately downregulated in the anterior pituitary during systemic inflammatory stress in cattle[AVP receptor V3 (show AVPR1B Antibodies)]
CRF (show CRH Antibodies) is expressed in tadpole tail, is up-regulated by environmental stressors, and is cytoprotective
CRFr1 activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 (show CRHR2 Antibodies) activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.
The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated
The results of this study suggested that variation in CRHR1 may influence brain function before any childhood adversity and may be a diathesis for the interaction between CRHR1 genotypes and childhood trauma reported to affect human psychopathology
Results suggest that blockade of CRF1 and CRF2 receptors in the basolateral and central nuclei of the amygdala reduces the duration of tonic immobility behavior associated with extreme threat situations, probably due to decreased fear and/or anxiety.
This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene.
corticotropin releasing hormone receptor variant 1e
, corticotropin releasing hormone receptor variant 1g
, corticotropin-releasing factor receptor 1
, corticotropin-releasing factor type 1 receptor
, corticotropin-releasing hormone receptor 1
, seven transmembrane helix receptor
, corticotropin releasing factor receptor type 1
, CRH-R 1
, corticotrophin releasing hormone receptor 1
, corticotropin releasing hormone 1
, CRF 1 receptor
, corticotropin releasing hormone receptor type I
, corticotropin releasing hormone receptor 1
, corticotrophin-releasing factor type 1 alpha receptor
, CRHR1-IT1-CRHR1 protein
, CRHR1-IT1-CRHR1 readthrough
, Corticotropin-releasing hormone receptor 1